Protein Alignment CG4069 and KLHDC10

DIOPT Version :10

• Sequence 1: NP_648590.1
• Gene: CG4069 / 39437
• FlyBaseID: FBgn0036301
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_055812.1
• Gene: KLHDC10 / 23008
• HGNCID: 22194
• Length: 442
• Species: Homo sapiens
• Alignment Length: 391
• Identity: 90/391 - (23%)
• Similarity: 152/391 - (38%)
• Gaps: 82/391 - (20%)

  Fly   113 RQLKSPSGPTPRSGHQMVAVASNGGELWMFGG------EHASPSQLQFHHYKDLWKFALKSRKWE 171
            |.|:....|..||||:.||..:|   |::|||      |...|....:..:::||::...:..|.
Human    81 RFLRGHRPPPARSGHRCVADNTN---LYVFGGYNPDYDESGGPDNEDYPLFRELWRYHFATGVWH 142

  Fly   172 RIAAPNGPSPR--SGHRMTVSKKRLFIFGG----FHDNNQSYHYFNDVHIFSLESYQWLKAEIGG 230
            ::.. :|..||  :...:.:....|.:|||    |.::|.     ||||:.:::..:|......|
Human   143 QMGT-DGYMPRELASMSLVLHGNNLLVFGGTGIPFGESNG-----NDVHVCNVKYKRWALLSCRG 201

  Fly   231 AIVPSPRSGCCIAASPEGKIYVWGGYSRAAMKKEADRGVTHTDMFVLSQDKNAGDADNKYKWAPV 295
            . .||...|..:|.. .|.:||:||                |..::.|.|.:..|. |..:|..:
Human   202 K-KPSRIYGQAMAII-NGSLYVFGG----------------TTGYIYSTDLHKLDL-NTREWTQL 247

  Fly   296 KPGGYK-PKPRSSVGCTVAANG-KAYTFGG-----VMDVDEDDEDVHGQFGDDLLAFDLTSQTWR 353
            ||.... ..|.......:|.:| :.|..||     ...:::    :|        |::|.:..|
Human   248 KPNNLSCDLPEERYRHEIAHDGQRIYILGGGTSWTAYSLNK----IH--------AYNLETNAW- 299

  Fly   354 LQEIQTKSSSAEKKDSEESKDVEMSAVDKPVTTTTDGIFTVTVGGP----STSTTPFVSKIPSLF 414
             :||.||..  ||.....::........|.......|.....:.|.    :..|..:| |:|:
Human   300 -EEIATKPH--EKIGFPAARRCHSCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQWV-KLPA-- 358

  Fly   415 AKPKPTNVPSPRMNPGMCVCKGTLYIFGGIFEEDDKQLTYNDF----YALDLHKLEWKVLI---P 472
            ..|:|.......:.|..|     :||.||:....:.:.|.:.|    ....|.:|.|:.|:   |
Human   359 TMPEPVYFHCAAVTPAGC-----MYIHGGVVNIHENKRTGSLFKIWLVVPSLLELAWEKLLAAFP 418

  Fly   473 N 473
            |
Human   419 N 419

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4069	NP_648590.1	NanM	64..353	CDD:442289	60/258 (23%)
		KELCH repeat	69..120	CDD:276965	2/6 (33%)
		KELCH repeat	124..179	CDD:276965	16/60 (27%)
		KELCH repeat	305..353	CDD:276965	8/53 (15%)
		Kelch_5	423..463	CDD:433528	8/43 (19%)
		KELCH repeat	426..470	CDD:276965	11/47 (23%)
KLHDC10	NP_055812.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..57
		Kelch 1. /evidence=ECO:0000269|PubMed:39548056, ECO:0007744|PDB:9D8P	87..154		20/70 (29%)
		NanM	89..401	CDD:442289	82/363 (23%)
		KELCH repeat	92..150	CDD:276965	17/61 (28%)
		KELCH repeat	154..204	CDD:276965	12/55 (22%)
		Kelch 2. /evidence=ECO:0000269|PubMed:39548056, ECO:0007744|PDB:9D8P	155..198		11/47 (23%)
		Kelch 3. /evidence=ECO:0000269|PubMed:39548056, ECO:0007744|PDB:9D8P	199..260		19/79 (24%)
		KELCH repeat	208..256	CDD:276965	15/65 (23%)
		KELCH repeat	260..313	CDD:276965	15/68 (22%)
		Kelch 4. /evidence=ECO:0000269|PubMed:39548056, ECO:0007744|PDB:9D8P	261..319		15/73 (21%)
		KELCH repeat	316..362	CDD:276965	7/48 (15%)
		Kelch 5. /evidence=ECO:0000269|PubMed:39548056, ECO:0007744|PDB:9D8P	320..364		8/46 (17%)
		Kelch 6. /evidence=ECO:0000269|PubMed:39548056, ECO:0007744|PDB:9D8P	365..403		8/42 (19%)
		Interaction with CUL2. /evidence=ECO:0000269|PubMed:23102700	401..442		6/19 (32%)