DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4069 and Fbxo42

DIOPT Version :9

Sequence 1:	NP_648590.1	Gene:	CG4069 / 39437	FlyBaseID:	FBgn0036301	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_766106.2	Gene:	Fbxo42 / 213499	MGIID:	1924992	Length:	717	Species:	Mus musculus

Alignment Length:	506	Identity:	110/506 - (21%)
Similarity:	179/506 - (35%)	Gaps:	131/506 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 KEGKIEAISESVCPPPTP---RSNFTLVCHPEKEELIMFGGELYTGTKTTVYNDLFFYNTKTVEW 112
            :||.|:..|.:...|.||   |.:.:...:...:.:.:||| ....:....:|||:..:..:.||
Mouse    98 QEGNIQWESRTYPYPGTPITQRFSHSACYYDANQSMYVFGG-CTQSSCNAAFNDLWRLDLNSKEW 161

  Fly   113 -RQLKSPSGPTPRSGHQMVAVASNGGELWMFGGEHASPSQLQFHH----YKDLWKFALKSRKWER 172
             |.|.|.|.|:|::|..:|....   .|.:||| ...||....|.    :.::..::.....|..
Mouse   162 IRPLASGSYPSPKAGATLVVYKD---LLVLFGG-WTRPSPYPLHQPERFFDEIHTYSPSKNWWNC 222

  Fly   173 IAAPNGPSPRSGHRMTVSKKRLFIFGGFHDNNQSYHYFNDVHIFSLESYQWLKAEIGGAIVPSPR 237
            |...:||.|.:||...|...::.:|||...:.|   ..|:|.:..||.:.|.|..|.|. .|.||
Mouse   223 IVTTHGPPPMAGHSSCVIGDKMIVFGGSLGSRQ---MSNEVWVLDLEQWAWSKPNISGP-SPHPR 283

  Fly   238 SGCCIAASPEGKIYVWGGYS--RAAMKKEADRGVTH--------TDMFVLSQDKNAGDADNKYKW 292
            .|.......:..:.:.||..  .|..|   |..:.|        ..:.|.::|..|.:.     |
Mouse   284 GGQSQIVIDDTTLLILGGCGGPNALFK---DAWLLHMHPGPWAWQPLKVENEDHGAPEL-----W 340

  Fly   293 ---------------------APVKPG-GYKPKPRSSVGCTVAANGKAYTFGGVMDVDEDDEDVH 335
                                 ||:.|. ..:|.|.|:....:....:.|.....:...::...|:
Mouse   341 CHPACRVGQCVVVFSQAPSGRAPLSPSLNSRPSPISATPPALVPETREYRSQSPVRSMDEAPCVN 405

  Fly   336 GQFGDDLLAFDLTSQTWRLQEIQTKSSSAEKKDSEESKDVEMSAVDKPVT---TTTDGIFTVTVG 397
            |::|      .|..:..|    ||.|.|.|...|....|      ..|:.   ..:.|  ||.||
Mouse   406 GRWG------TLRPRAQR----QTPSGSREGSLSPARGD------GSPILNGGNLSPG--TVAVG 452

  Fly   398 GPSTSTTPFVSKIPSLFAKPKPTNVPSPR---------MNPGMCVC--KGTLYIFGGIFEEDDKQ 451
            |.|..:               |..|.||.         :..|:.:.  :|:|        .|.|.
Mouse   453 GASLDS---------------PVQVVSPSTPSASDGYDLKVGLSLAPRRGSL--------PDQKD 494

  Fly   452 LTYNDFYALDLHKLEWKVLIPNSLKGHEWEDSDSSSSDEECSGSEEDISSS 502
            |..:   ::||:                |:...:|||....|.....::.|
Mouse   495 LRLS---SIDLN----------------WDLKSASSSSHVDSIDNRTVAGS 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4069	NP_648590.1	KELCH repeat	69..120	CDD:276965	12/51 (24%)
		Kelch_3	80..132	CDD:290151	16/52 (31%)
		KELCH repeat	124..179	CDD:276965	11/58 (19%)
		Kelch_3	136..189	CDD:290151	14/56 (25%)
		Kelch_3	191..244	CDD:290151	16/52 (31%)
		Kelch_2	237..297	CDD:284956	14/90 (16%)
		KELCH repeat	305..353	CDD:276965	6/47 (13%)
		Kelch_5	423..463	CDD:290565	9/50 (18%)
		KELCH repeat	426..470	CDD:276965	8/54 (15%)
Fbxo42	NP_766106.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34
		F-box-like	47..>82	CDD:289689
		KELCH repeat	119..168	CDD:276965	11/49 (22%)
		Kelch_3	130..182	CDD:290151	16/52 (31%)
		Kelch 1	132..184		16/52 (31%)
		KELCH repeat	174..229	CDD:276965	11/58 (19%)
		Kelch_3	183..240	CDD:290151	14/60 (23%)
		Kelch 2	186..242		15/56 (27%)
		KELCH repeat	232..271	CDD:276965	11/41 (27%)
		Kelch_3	241..283	CDD:290151	13/45 (29%)
		Kelch 3	244..293		16/52 (31%)
		Kelch 4	295..342		10/54 (19%)
		Hepatitis_core	<317..432	CDD:279277	22/129 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	361..452		23/108 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	570..632
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1494
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940