DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4069 and F53E4.1

DIOPT Version :9

Sequence 1:	NP_648590.1	Gene:	CG4069 / 39437	FlyBaseID:	FBgn0036301	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_001368706.1	Gene:	F53E4.1 / 180050	WormBaseID:	WBGene00009978	Length:	432	Species:	Caenorhabditis elegans

Alignment Length:	364	Identity:	88/364 - (24%)
Similarity:	129/364 - (35%)	Gaps:	106/364 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 KSRKWERIAAPNGPSPRSGHRMTVSKKRLFIFGGF-----HDNNQSYHYFNDVHIFSLESYQWLK 225
            |...| .:....||. |..|.......|::.|||:     .|.....    |||:.:.|:|:|:|
Worm     6 KMATW-TVHLEGGPR-RVNHASIAVGSRIYSFGGYCSGEVTDAKDPL----DVHVLNTENYRWIK 64

  Fly   226 AEIG---------GAIVPSPRSGC--CIAASP-----------EGKIYVWGGYSRAAMKKEADRG 268
            ...|         .|.:.||.|..  ...|.|           :||.|||||       :..|.|
Worm    65 MNPGYVYNNRIITKATIESPYSDSDKMFGAVPYQRYGHTVVEYQGKAYVWGG-------RNDDYG 122

  Fly   269 VTHTDMFVLSQDKNAGDADNKYK-WAPVKPGGYKPKPRSSVGCT-VAANGKAYTFGGVMDVDEDD 331
            ..:.          ..:.|.:|. |..|:..|:.|..|.  |.| |..|.:.:.|||.      :
Worm   123 ACNL----------LHEYDPEYNVWKKVEIEGFVPPSRD--GHTAVVWNNQMFVFGGY------E 169

  Fly   332 EDVHGQFGDDLLAFDLTSQTWRLQEIQTKSSSAEKKD-----------------SEESKDVEMSA 379
            ||.. :|..:...||..:.|||  |:.||:.....:|                 |:||..|.
Worm   170 EDAQ-RFSQETYVFDFATSTWR--EMHTKNDPPRWRDFHTASVIDGMMYIFGGRSDESGQVG--- 228

  Fly   380 VDKPVTTTTDGIFTVTVGGPSTSTTPFVSKIPSLFAKPKPTNVPSPRMNPG------MCVCKGTL 438
             |:.:..|....:..|:...:.:|..:..           |.||...|.||      ..|..|.:
Worm   229 -DEHLFHTIHDQYDDTLMALNLATGAWTR-----------TKVPENTMKPGGRRSHSTWVYDGKM 281

  Fly   439 YIFGGIFEEDDKQLTYNDFYALDLHKLEWKVLIPNSLKG 477
            |:|||..  ....:.||:.|..|.....|.|:   |::|
Worm   282 YMFGGYL--GTINVHYNELYCFDPKTSMWSVI---SVRG 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4069	NP_648590.1	KELCH repeat	69..120	CDD:276965
		Kelch_3	80..132	CDD:290151
		KELCH repeat	124..179	CDD:276965	2/12 (17%)
		Kelch_3	136..189	CDD:290151	6/22 (27%)
		Kelch_3	191..244	CDD:290151	17/68 (25%)
		Kelch_2	237..297	CDD:284956	16/73 (22%)
		KELCH repeat	305..353	CDD:276965	14/48 (29%)
		Kelch_5	423..463	CDD:290565	14/45 (31%)
		KELCH repeat	426..470	CDD:276965	14/49 (29%)
F53E4.1	NP_001368706.1	KELCH repeat	99..148	CDD:276965	14/65 (22%)
		KELCH repeat	150..192	CDD:276965	16/52 (31%)
		KELCH repeat	202..266	CDD:276965	13/78 (17%)
		KELCH repeat	269..312	CDD:276965	12/47 (26%)
		Kelch_2	19..67	CDD:400133	14/52 (27%)
		KELCH repeat	20..91	CDD:276965	19/74 (26%)
		PLN02153	79..>338	CDD:177814	69/285 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1494
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940