DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4069 and KLHDC3

DIOPT Version :9

Sequence 1:NP_648590.1 Gene:CG4069 / 39437 FlyBaseID:FBgn0036301 Length:509 Species:Drosophila melanogaster
Sequence 2:XP_024302088.1 Gene:KLHDC3 / 116138 HGNCID:20704 Length:395 Species:Homo sapiens


Alignment Length:333 Identity:69/333 - (20%)
Similarity:117/333 - (35%) Gaps:98/333 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    81 EELIMFGGELYTGTKTTVYNDLFFYNTKTVEWRQLK-SPSGPTPRSGHQMVAVASNGGELWMFGG 144
            :.::::||...|   ....|.|:.::..|.:|...: |.:.|..|.||....:   |..:::|||
Human   100 DTVLLWGGRNDT---EGACNVLYAFDVNTHKWFTPRVSGTVPGARDGHSACVL---GKIMYIFGG 158

  Fly   145 EHASPSQLQFHHYKDLWKFALKSRKWERIAAPNGPSP-RSGHRMTVSKKRLFIFGG-------FH 201
            .........    .|:.|....:..|..|.....|:. |..|..|:....:::|||       ||
Human   159 YEQQADCFS----NDIHKLDTSTMTWTLICTKGSPARWRDFHSATMLGSHMYVFGGRADRFGPFH 219

  Fly   202 DNNQSYHYFNDVHIFSLESYQWLKAEIGGAIVPSPRSGCCIAASPEGK-----------IYVWGG 255
            .||:.  |.|.:.:|...:..||...      |:|       ..|||:           :|::||
Human   220 SNNEI--YCNRIRVFDTRTEAWLDCP------PTP-------VLPEGRRSHSAFGYNGELYIFGG 269

  Fly   256 YSRAAMKKEADRGVTHTDMFVLSQDKNAGDADNKYKWAPVKPGGYKPKPRSSVGCTVAANGKAYT 320
            |: |.:.:.      ..|::..:        ...:.|..::|.|..|.||....|.:..: |...
Human   270 YN-ARLNRH------FHDLWKFN--------PVSFTWKKIEPKGKGPCPRRRQCCCIVGD-KIVL 318

  Fly   321 FGGVMDVDE----------DDEDVHGQFGDDLLAFDLTSQT---------------------WRL 354
            |||.....|          |..|:|      :|.|..:.:|                     |.|
Human   319 FGGTSPSPEEGLGDEFDLIDHSDLH------ILDFSPSLKTLCKLAVIQYNLDQSCLPHDIRWEL 377

  Fly   355 QEIQTKSS 362
            ..:.|.|:
Human   378 NAMTTNSN 385

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4069NP_648590.1 KELCH repeat 69..120 CDD:276965 8/39 (21%)
Kelch_3 80..132 CDD:290151 12/51 (24%)
KELCH repeat 124..179 CDD:276965 11/54 (20%)
Kelch_3 136..189 CDD:290151 11/53 (21%)
Kelch_3 191..244 CDD:290151 14/59 (24%)
Kelch_2 237..297 CDD:284956 10/70 (14%)
KELCH repeat 305..353 CDD:276965 13/78 (17%)
Kelch_5 423..463 CDD:290565
KELCH repeat 426..470 CDD:276965
KLHDC3XP_024302088.1 PLN02193 63..>331 CDD:330882 59/271 (22%)
KELCH repeat 90..135 CDD:276965 7/37 (19%)
KELCH repeat 141..186 CDD:276965 11/51 (22%)
KELCH repeat 193..249 CDD:276965 17/70 (24%)
KELCH repeat 252..296 CDD:276965 7/58 (12%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1494
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.940

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