Protein Alignment Pmm2 and PMM2

DIOPT Version :10

• Sequence 1: NP_648589.1
• Gene: Pmm2 / 39436
• FlyBaseID: FBgn0036300
• Length: 254
• Species: Drosophila melanogaster
• Sequence 2: NP_000294.1
• Gene: PMM2 / 5373
• HGNCID: 9115
• Length: 246
• Species: Homo sapiens
• Alignment Length: 236
• Identity: 131/236 - (55%)
• Similarity: 178/236 - (75%)
• Gaps: 3/236 - (1%)

  Fly    12 LLLFDVDGTLTMPRSVVTPEFEEFFYSRVKPRATIGIVGGSDLEKMFEQLNGRKILNEFDFIFPE 76
            |.|||||||||.||..:|.|.::|. .:::.:..||:|||||.||:.||| |..::.::|::|||
Human     8 LCLFDVDGTLTAPRQKITKEMDDFL-QKLRQKIKIGVVGGSDFEKVQEQL-GNDVVEKYDYVFPE 70

  Fly    77 NGLVQIEGGKEVGKQNIIMHLGEETVKRFINFVLRYLSELDVPIKRGTFIEFRNGMMNVCPIGRQ 141
            ||||..:.||.:.:|||..||||..::..||:.|.|::::.:|.||||||||||||:||.||||.
Human    71 NGLVAYKDGKLLCRQNIQSHLGEALIQDLINYCLSYIAKIKLPKKRGTFIEFRNGMLNVSPIGRS 135

  Fly   142 CTREERNMFAEYDIEHKVREKMIKDLKQEFADVDLTYSIGGQISFDVFPHGWDKTYCLRHIEAHY 206
            |::|||..|.|.|.:..:|:|.:.||::|||...||:||||||||||||.||||.|||||:| :.
Human   136 CSQEERIEFYELDKKENIRQKFVADLRKEFAGKGLTFSIGGQISFDVFPDGWDKRYCLRHVE-ND 199

  Fly   207 KFKEIHFFGDKTEPGGNDYEIYSDPRTISHRVYTPKDTQRI 247
            .:|.|:||||||.|||||:||::||||:.:.|..|:||:||
Human   200 GYKTIYFFGDKTMPGGNDHEIFTDPRTMGYSVTAPEDTRRI 240

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pmm2	NP_648589.1	HAD_PMM	12..251	CDD:319784	131/236 (56%)
PMM2	NP_000294.1	HAD_PMM	8..244	CDD:319784	131/236 (56%)