DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pmm2 and pmm1

DIOPT Version :9

Sequence 1:	NP_648589.1	Gene:	Pmm2 / 39436	FlyBaseID:	FBgn0036300	Length:	254	Species:	Drosophila melanogaster
Sequence 2:	NP_594325.1	Gene:	pmm1 / 2541674	PomBaseID:	SPAC1556.07	Length:	257	Species:	Schizosaccharomyces pombe

Alignment Length:	250	Identity:	131/250 - (52%)
Similarity:	167/250 - (66%)	Gaps:	4/250 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KRDEILLLFDVDGTLTMPRSVVTPEFEEFFYSRVKPRATIGIVGGSDLEKMFEQL--NGRKILNE 69
            |..:.|:|||||||||..|..|:||..|.. ..::....||.||||||.|..|||  ||..:::.
pombe    10 KFPKTLVLFDVDGTLTPARLSVSPEMLETL-QNLRKVVAIGFVGGSDLSKQQEQLSVNGENVIDS 73

  Fly    70 FDFIFPENGLVQIEGGKEVGKQNIIMHLGEETVKRFINFVLRYLSELDVPIKRGTFIEFRNGMMN 134
            ||:.|.||||.....|:::..|:.|..||||..::.:||.|.|:::||:|:||||||||||||:|
pombe    74 FDYAFAENGLTAYRYGQQLASQSFIAWLGEEKYQKLVNFCLHYIADLDIPVKRGTFIEFRNGMIN 138

  Fly   135 VCPIGRQCTREERNMFAEYDIEHKVREKMIKDLKQEFADVDLTYSIGGQISFDVFPHGWDKTYCL 199
            :.|:||....||||.|..:|...|:|..|:..|:::|.|..||:||||||||||||.||||||||
pombe   139 ISPVGRNANTEERNEFERFDKGRKIRATMVDVLREKFKDYGLTFSIGGQISFDVFPAGWDKTYCL 203

  Fly   200 RHIEAHYKFKEIHFFGDKTEPGGNDYEIYSDPRTISHRVYTPKDTQRILTEILEL 254
            :|:|.. .|..||||||||..|||||||:.|||||.|.|..|.||...|.:|..:
pombe   204 QHVEKE-GFDTIHFFGDKTYKGGNDYEIFVDPRTIGHSVTNPDDTIAELKKIFNI 257

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pmm2	NP_648589.1	HAD-SF-IIB	12..234	CDD:273651	121/223 (54%)
Pmm2	NP_648589.1	PMM	33..254	CDD:281343	116/222 (52%)
pmm1	NP_594325.1	HAD_like	13..>56	CDD:304363	21/43 (49%)
		HAD-SF-IIB	15..239	CDD:273651	123/225 (55%)
		PMM	36..257	CDD:281343	116/222 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	240	1.000	Domainoid score	I463
eggNOG	1	0.900	-	-		E1_COG0561
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H257
Inparanoid	1	1.050	260	1.000	Inparanoid score	I748
OMA	1	1.010	-	-		QHG53697
OrthoFinder	1	1.000	-	-		FOG0002294
OrthoInspector	1	1.000	-	-		oto101328
orthoMCL	1	0.900	-	-		OOG6_101634
Panther	1	1.100	-	-	LDO	PTHR10466
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R935
SonicParanoid	1	1.000	-	-		X1518
TreeFam	1	0.960	-	-
	14	13.860