DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tsf2 and meltf

DIOPT Version :9

Sequence 1:	NP_524044.1	Gene:	Tsf2 / 39435	FlyBaseID:	FBgn0036299	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	XP_009300716.1	Gene:	meltf / 565942	ZFINID:	ZDB-GENE-050309-40	Length:	724	Species:	Danio rerio

Alignment Length:	836	Identity:	250/836 - (29%)
Similarity:	387/836 - (46%)	Gaps:	167/836 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 HHYDEHKTTRMVWCTKSQAEQYKCQNLTVAIERDRALFDEVFLN--LTCFMAYSADECIHHIDRE 85
            |:.....|.|  ||..|.||:.||:.:..|       |....:.  |.|.:|.|..||...:.::
Zfish    15 HYVSGQSTIR--WCVISVAEESKCKAMAQA-------FSSASVRPALKCVLAASKAECAQKLTQK 70

  Fly    86 K-AHITTLDAGDVFTAGRYNSL-IPIMQEKLEGGFADYQSVAVIKK-GSLPDLNNLRDMRNKRVC 147
            | ....:..|.|::..|:..|. |...:...:|....|..|||:|| .:..::|||   :.|:.|
Zfish    71 KEVDAFSASAKDIYDIGKLASFKIAAGESGSDGKGITYYGVAVVKKTNAAININNL---KGKKSC 132

  Fly   148 FPWVGSLAGWIVPIHTLQREGGMEVVDCNNQVKTAASYFNNSCAVYSLSDKHNPIGDNSDKLCTL 212
            .......|||.||:..|...|.|.|:.||.. :..|.:||.||...:        .|:...||..
Zfish   133 HTGKNRTAGWNVPLGYLIDSGMMSVMGCNIP-QGVADFFNASCIPGA--------KDDPASLCQQ 188

  Fly   213 CTGKIPGG-RC--SSADPYFGYEGAFKCLLE-KGDVAFLRHSTVNEMLQTTEFK------NIAPD 267
            |.|...|. :|  |:.:.|:.|:|||:||:| .|||||::|:||:|   .|:.|      .:...
Zfish   189 CVGDRTGQFKCDPSNKELYYAYDGAFRCLVEDAGDVAFVKHTTVSE---NTDGKGASWAQELQSK 250

  Fly   268 TFELLCRDGRRASINDYRQCNWGQVPADAIVTSSARSFSDRKQYQQFLKRIAELYSDGTRDDQSR 332
            .::||||||.|:.:.||.:|:..:||:..||                      ::.|.|
Zfish   251 DYQLLCRDGTRSPVTDYEKCHLARVPSRGIV----------------------IHPDIT------ 287

  Fly   333 QGGQSFNSRNNINDQNAYGQFDNNDPYRTQNQYDQYRSERLDSSFAEERNQQDGTNTSILYEK-- 395
                                                                    ||::|..
Zfish   288 --------------------------------------------------------TSVVYNMLT 296

  Fly   396 -------FRIFESKRYGKPNLLFQDSSRALTVIPEDDQSFTKYLGPAINFIYGIREC---PVPA- 449
                   |.:|.|..:|..||||.|:|...  |...::::.:::|...:.:..: :|   .:|:
Zfish   297 EGLQKSGFSMFSSADFGGENLLFSDTSTKF--IQAGNENYKEWMGRYYHILKAM-DCSQSDIPSQ 358

  Fly   450 MTLCVTSENELDKCIKMRTALKAHLLKPELICKKMHSHINCMQFIEAGKADISVFDAGDVYTGGL 514
            :..||.|..|..||..|..|.|...|.|.:.|....|..:||:.|:..:||....|.|.:||.|.
Zfish   359 LQWCVLSHGEQQKCADMAVAFKNKNLIPNIQCVYGASVEDCMKKIQNKEADAITLDGGYIYTAGK 423

  Fly   515 NYDLVPFMSEVYNLGEPE---YYVVAVAKEDDPDTE-LTYLKGKNTCHTGINTAAGWTYPMALFI 575
            :|.|:|.:.|.|. |:.:   ||.|||.::.:.|.: .:.||||.:||||....|||..||.|.|
Zfish   424 SYGLIPAVGESYT-GDSDGSIYYAVAVLRKSNRDIQRFSDLKGKRSCHTGYGRTAGWNIPMGLLI 487

  Fly   576 SNGWIRPYGCDSVRAAAEYFTKSCVPGAISNEYNTGVPYDSMCDLCHGTSYRYCRRDASEEYY-G 639
            ..|.|||..|...:||.|:|..:|||||...::.     :::|..|.|.|....:....::.| |
Zfish   488 EKGIIRPQTCQVAQAAGEFFESACVPGADQKDFP-----ENLCKQCIGDSSGQFKCVKGKDLYDG 547

  Fly   640 HTGAFRCLVEGGGHVAFMKHTTVMESTGGKRKEWWARNALNDDFELLCTDGTRAEIQDYKRCNLG 704
            :.||||||||..|.|||:||:||.::|.|...:.||.|..:.:|:|||:..:|||:..:.:|||.
Zfish   548 YDGAFRCLVENHGDVAFVKHSTVFQNTDGNNTDPWAVNLDSREFQLLCSQESRAEVTQFTKCNLA 612

  Fly   705 KVKANAVVTRGGVNYNETQMNAYINLLTYAQQLYGRKEVDAFSFSMFSSPIGHY---DLIFQDAT 766
            :|.::||:.|...|:     :....||..||:.:|..  .|..|.||.|..  |   ||||:|:|
Zfish   613 RVPSHAVMIRPDTNH-----HIIFGLLDKAQRFFGVN--SASDFKMFDSKA--YEGSDLIFKDST 668

  Fly   767 RQLQVIPPNKRR-YDAYLGSDFMRARRITDCYAGASQLALSVGLL--LVGSLVAML 819
              :.:|...:|: |:.:||..::.:....:|.|.::..:.|..||  :|.|||::|
Zfish   669 --ITLIGVGERKTYEEWLGQSYLDSLIAMECSASSTVFSFSSLLLMSIVSSLVSLL 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tsf2	NP_524044.1	PBP2_transferrin	32..372	CDD:270247	93/354 (26%)
		PBP2_transferrin	450..792	CDD:270247	128/350 (37%)
		TR_FER	452..790	CDD:214514	128/346 (37%)
meltf	XP_009300716.1	PBP2_transferrin	22..343	CDD:270247	109/430 (25%)
		TR_FER	23..349	CDD:214514	108/436 (25%)
		Periplasmic_Binding_Protein_Type_2	358..689	CDD:304360	128/347 (37%)
		TR_FER	360..689	CDD:214514	128/345 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	208	1.000	Domainoid score	I2807
eggNOG	1	0.900	-	-		E1_28KI0
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4335
Inparanoid	1	1.050	354	1.000	Inparanoid score	I2216
OMA	1	1.010	-	-		QHG45906
OrthoDB	1	1.010	-	-		D125278at33208
OrthoFinder	1	1.000	-	-		FOG0007989
OrthoInspector	1	1.000	-	-		otm26146
orthoMCL	1	0.900	-	-		OOG6_106912
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7331
SonicParanoid	1	1.000	-	-		X1208
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770