DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tsf2 and otomp

DIOPT Version :9

Sequence 1:	NP_524044.1	Gene:	Tsf2 / 39435	FlyBaseID:	FBgn0036299	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_001038552.1	Gene:	otomp / 565818	ZFINID:	ZDB-GENE-040709-1	Length:	371	Species:	Danio rerio

Alignment Length:	350	Identity:	114/350 - (32%)
Similarity:	175/350 - (50%)	Gaps:	18/350 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   453 CVTSENELDKCIKMRTALKAHLLKPELICKKMHSHINCMQFIEAGKADISVFDAGDVYTGGLNYD 517
            |..|:.|..||:.:.....|..|:.:|:|.:..|..:||:.|:.|.||.|...|.::||.|..|.
Zfish    30 CTVSDAEDQKCLDLAGNATARNLRGQLVCVRGQSPTDCMKQIKNGTADASTMYADEIYTAGFCYG 94

  Fly   518 LVPFMSEVYN-LGEPEYYVVAVAKEDDPDTELTYLKGKNTCHTGINTAAGWTYPMALFISNGWIR 581
            |...:.|.|| :....|||||:|:....|..|..:..:::||.|:.|..|||.|:...::...|.
Zfish    95 LDVAVGESYNGVDGINYYVVALARTSSSDLSLLEMHERSSCHPGMRTTVGWTVPIGFLVNTSQIS 159

  Fly   582 -PYGCDSVRAAAEYFTKSCVPGAISNEYN-TGVPYDSMCDLCHG--TSYRYCRRDASEEYYGHTG 642
             ...|:...|..::|..|||||....|:: .|....::|:.|.|  .....|..:..|.::|..|
Zfish   160 VDVQCNFPHAVGDFFGYSCVPGVKDPEHDPKGNNPRNLCEACIGDENDRHICANNPRERHFGEAG 224

  Fly   643 AFRCLVEGGGHVAFMKHTTVMESTGGKRKEWWARNALNDDFELLCTDGTRAEIQDYKRCNLGKVK 707
            |.||:.|..|.|||:|||||.::..||.:|.||.:...:|.:|||.||:.|.:..::.|:|..|.
Zfish   225 ALRCVAENLGDVAFVKHTTVFDNMQGKNQESWALDLELEDLKLLCPDGSEANLFQHESCHLAVVP 289

  Fly   708 ANAVVTRGGVNYNETQMNAYINLLTYAQQLYGRKEVDAFSFSMFSS-PIGHYDLIFQDATRQLQV 771
            .||||.|     .|.:...| ..|...|..:|.   ....||:||| ..|..|::|.|:|::|..
Zfish   290 TNAVVVR-----LEDKCRVY-KFLERVQNAFGN---TTEGFSLFSSVNYGQPDVLFSDSTKKLLR 345

  Fly   772 IPPNKRRYDAYLGSDFMRARRITDC 796
            :   ...|.::||..:....|..:|
Zfish   346 V---MGTYTSWLGPSYTTILRAFEC 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tsf2	NP_524044.1	PBP2_transferrin	32..372	CDD:270247
		PBP2_transferrin	450..792	CDD:270247	112/344 (33%)
		TR_FER	452..790	CDD:214514	112/342 (33%)
otomp	NP_001038552.1	TR_FER	27..363	CDD:214514	112/344 (33%)
otomp	NP_001038552.1	PBP2_transferrin	27..363	CDD:270247	112/344 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583236
Domainoid	1	1.000	208	1.000	Domainoid score	I2807
eggNOG	1	0.900	-	-		E1_28KI0
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125278at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26146
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	7	6.710