DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tsf2 and MELTF

DIOPT Version :9

Sequence 1:	NP_524044.1	Gene:	Tsf2 / 39435	FlyBaseID:	FBgn0036299	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	XP_011511152.1	Gene:	MELTF / 4241	HGNCID:	7037	Length:	765	Species:	Homo sapiens

Alignment Length:	848	Identity:	275/848 - (32%)
Similarity:	397/848 - (46%)	Gaps:	175/848 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 WCTKSQAEQYKCQNLTVAIERDRALFDEVFL--NLTCFMAYSADECIHHIDREKAHITTLDAGDV 97
            ||..|..||:||.|::.|       |.|..:  :|.|....|||.|:..|..::|...|||.|.:
Human    25 WCATSDPEQHKCGNMSEA-------FREAGIQPSLLCVRGTSADHCVQLIAAQEADAITLDGGAI 82

  Fly    98 FTAGRYNSLIPIMQE--KLEGGFADYQSVAVIKKGSLPDLNNLRDMRNKRVCFPWVGSLAGWIVP 160
            :.||:.:.|.|::.|  ..|.| ..|.:|||:::.|...::.|:.:::   |...:....||.||
Human    83 YEAGKEHGLKPVVGEVYDQEVG-TSYYAVAVVRRSSHVTIDTLKGVKS---CHTGINRTVGWNVP 143

  Fly   161 IHTLQREGGMEVVDCNNQVKTAASYFNNSCAVYSLSDKHNPIGDNSDKLCTLCTGKIPG-GRC-- 222
            :..|...|.:.|:.| :.:|..:.||..||...:....:      |:.||.||.|...| |.|
Human   144 VGYLVESGRLSVMGC-DVLKAVSDYFGGSCVPGAGETSY------SESLCRLCRGDSSGEGVCDK 201

  Fly   223 SSADPYFGYEGAFKCLLE-KGDVAFLRHSTVNEMLQTTEFKN-------IAPDTFELLCRDGRRA 279
            |..:.|:.|.|||:||.| .|||||::||||   |:.|:.|.       :....||||||||.||
Human   202 SPLERYYDYSGAFRCLAEGAGDVAFVKHSTV---LENTDGKTLPSWGQALLSQDFELLCRDGSRA 263

  Fly   280 SINDYRQCNWGQVPADAIVTSSARSFSDRKQYQQFLKRIAELYSDGTRDDQSRQGGQSFNSRNNI 344
            .:.::|||:..:|||.|:|   .|:.:|                          ||..|...|
Human   264 DVTEWRQCHLARVPAHAVV---VRADTD--------------------------GGLIFRLLN-- 297

  Fly   345 NDQNAYGQFDNNDPYRTQNQYDQYRSERLDSSFAEERNQQDGTNTSILYEKFRIFESKRYGKPNL 409
                                    ..:||   |:.|.:            .|::|.|:.||:.:|
Human   298 ------------------------EGQRL---FSHEGS------------SFQMFSSEAYGQKDL 323

  Fly   410 LFQDSSRALTVIPEDDQSFTKYLGPAINFIYGIR-------ECPVPAMTLCVTSENELDKCIKMR 467
            ||:||:..|  :|...|::..:||.  .:::.::       ..| |.:..||.|..|:.||..|.
Human   324 LFKDSTSEL--VPIATQTYEAWLGH--EYLHAMKGLLCDPNRLP-PYLRWCVLSTPEIQKCGDMA 383

  Fly   468 TALKAHLLKPELICKKMHSHINCMQFIEAGKADISVFDAGDVYTGGLNYDLVPFMSEVYNLGEPE 532
            .|.:...||||:.|....|..:||:.|:|.:.|.......|:||.|..|.|||...|.|   .||
Human   384 VAFRRQRLKPEIQCVSAKSPQHCMERIQAEQVDAVTLSGEDIYTAGKTYGLVPAAGEHY---APE 445

  Fly   533 -----YYVVAVAKEDDPDT-ELTYLKGKNTCHTGINTAAGWTYPMALFISNGWIRPYGCDSVRAA 591
                 ||||||.:.|.... .|..|:||.:||.|..:.|||..|:...|..|:|||..||.:.|.
Human   446 DSSNSYYVVAVVRRDSSHAFTLDELRGKRSCHAGFGSPAGWDVPVGALIQRGFIRPKDCDVLTAV 510

  Fly   592 AEYFTKSCVPGAISNEYNTGVPYDSMCDLCHGTSY--RYCRRDASEEYYGHTGAFRCLVEGGGHV 654
            :|:|..||||  ::|..|  .| .|:|.||.|...  ..|..::.|.|||:.||||||||..|.|
Human   511 SEFFNASCVP--VNNPKN--YP-SSLCALCVGDEQGRNKCVGNSQERYYGYRGAFRCLVENAGDV 570

  Fly   655 AFMKHTTVMESTGGKRKEWWARNALNDDFELLCTDGTRAEIQDYKRCNLGKVKANAVVTRGGVNY 719
            ||::||||.::|.|...|.||....::|:||||.:|.|||:..:..|||.::..:||:.|
Human   571 AFVRHTTVFDNTNGHNSEPWAAELRSEDYELLCPNGARAEVSQFAACNLAQIPPHAVMVR----- 630

  Fly   720 NETQMNAYINLLTYAQQL----YGRKEV---------------DAF-------SFSMFSSPIGH- 757
            .:|.:.....||..|||.    .||..:               |.|       .|.||.|...|
Human   631 PDTNIFTVYGLLDKAQQFAASGTGRVTLPEPSEEQVVCLRCFQDLFGDDHNKNGFKMFDSSNYHG 695

  Fly   758 YDLIFQDATRQLQVIP-PNKRRYDAYLGSDFMRA---RRITDCYAGASQLALSVGL--LLVGSLV 816
            .||:|:|||  ::.:| ..|..|..:||.|::.|   .....| :||:..|....|  ||:.:|.
Human   696 QDLLFKDAT--VRAVPVGEKTTYRGWLGLDYVAALEGMSSQQC-SGAAAPAPGAPLLPLLLPALA 757

  Fly   817 AML 819
            |.|
Human   758 ARL 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tsf2	NP_524044.1	PBP2_transferrin	32..372	CDD:270247	104/351 (30%)
		PBP2_transferrin	450..792	CDD:270247	140/380 (37%)
		TR_FER	452..790	CDD:214514	139/373 (37%)
MELTF	XP_011511152.1	Transferrin	23..357	CDD:278817	123/426 (29%)
		PBP2_transferrin	23..355	CDD:270247	123/424 (29%)
		TR_FER	367..733	CDD:214514	140/380 (37%)
		PBP2_transferrin	367..731	CDD:270247	140/378 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	239	1.000	Domainoid score	I2287
eggNOG	1	0.900	-	-		E1_28KI0
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4335
Inparanoid	1	1.050	393	1.000	Inparanoid score	I1989
Isobase	1	0.950	-	0	Normalized mean entropy	S7803
OMA	1	1.010	-	-		QHG45906
OrthoDB	1	1.010	-	-		D125278at33208
OrthoFinder	1	1.000	-	-		FOG0007989
OrthoInspector	1	1.000	-	-		otm40877
orthoMCL	1	0.900	-	-		OOG6_106912
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7331
SonicParanoid	1	1.000	-	-		X1208
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.720