DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tsf2 and LTF

DIOPT Version :9

Sequence 1:NP_524044.1 Gene:Tsf2 / 39435 FlyBaseID:FBgn0036299 Length:819 Species:Drosophila melanogaster
Sequence 2:NP_002334.2 Gene:LTF / 4057 HGNCID:6720 Length:710 Species:Homo sapiens


Alignment Length:832 Identity:248/832 - (29%)
Similarity:354/832 - (42%) Gaps:195/832 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 LVFVAL--VGALCFTLANAQHHYDEHKTTRMVWCTKSQAEQYKCQNLTVAIERDRALFDEVFLNL 67
            |||:.|  :|||...||.        :...:.||..||.|..||......:.:.|.      ..:
Human     3 LVFLVLLFLGALGLCLAG--------RRRSVQWCAVSQPEATKCFQWQRNMRKVRG------PPV 53

  Fly    68 TCFMAYSADECIHHIDREKAHITTLDAGDVFTAGRYNSLIPIMQEKLEGGFAD-----------Y 121
            :|....|..:||..|...:|...|||.|.::.||    |.|.   ||....|:           |
Human    54 SCIKRDSPIQCIQAIAENRADAVTLDGGFIYEAG----LAPY---KLRPVAAEVYGTERQPRTHY 111

  Fly   122 QSVAVIKKGSLPDLNNLRDMRNKRVCFPWVGSLAGWIVPIHTLQR----EGGMEVVDCNNQVKTA 182
            .:|||:|||....||.|:.:::   |...:...|||.|||.||:.    .|..|.::.     ..
Human   112 YAVAVVKKGGSFQLNELQGLKS---CHTGLRRTAGWNVPIGTLRPFLNWTGPPEPIEA-----AV 168

  Fly   183 ASYFNNSCAVYSLSDKHNPIGDNSD--KLCTLCTGKIPGGRC--SSADPYFGYEGAFKCLLE-KG 242
            |.:|:.||.         |..|...  .||.||.| ....:|  ||.:|||.|.||||||.: .|
Human   169 ARFFSASCV---------PGADKGQFPNLCRLCAG-TGENKCAFSSQEPYFSYSGAFKCLRDGAG 223

  Fly   243 DVAFLRHSTVNEMLQTTEFKNIAPDTFELLCRDGRRASINDYRQCNWGQVPADAIVTSSARSFSD 307
            ||||:|.|||.|.|.....:    |.:||||.|..|..::.::.|:..:||:.|:|   |||.:.
Human   224 DVAFIRESTVFEDLSDEAER----DEYELLCPDNTRKPVDKFKDCHLARVPSHAVV---ARSVNG 281

  Fly   308 RKQYQQFLKRIAELYSDGTRDDQSRQGGQSFNSRNNINDQNAYGQFDNNDPYRTQNQYDQYRSER 372
            ::.....|.|.|                           |..:|:                    
Human   282 KEDAIWNLLRQA---------------------------QEKFGK-------------------- 299

  Fly   373 LDSSFAEERNQQDGTNTSILYEKFRIFESKRYGKPNLLFQDSSRALTVIPEDDQSFTKYLGPA-I 436
             |.|                 .||::|.|.. |:.:|||:||:...:.:|....| ..|||.. .
Human   300 -DKS-----------------PKFQLFGSPS-GQKDLLFKDSAIGFSRVPPRIDS-GLYLGSGYF 344

  Fly   437 NFIYGIR--ECPVPA----MTLCVTSENELDKCIKMRTALKAHLLKPELICKKMHSHINCMQFIE 495
            ..|..:|  |..|.|    :..|...|.||.||.:.     :.|.:..:.|....:..:|:..:.
Human   345 TAIQNLRKSEEEVAARRARVVWCAVGEQELRKCNQW-----SGLSEGSVTCSSASTTEDCIALVL 404

  Fly   496 AGKADISVFDAGDVYTGGLNYDLVPFMSEVY---NLGEPE----------YYVVAVAKEDDPDTE 547
            .|:||....|.|.|||.| ...|||.::|.|   ...:|:          |..|||.:..  ||.
Human   405 KGEADAMSLDGGYVYTAG-KCGLVPVLAENYKSQQSSDPDPNCVDRPVEGYLAVAVVRRS--DTS 466

  Fly   548 LTY--LKGKNTCHTGINTAAGWTYPMA-LFISNGWIRPYGCDSVRAAAEYFTKSCVPGAISNEYN 609
            ||:  :|||.:|||.::..|||..||. ||...|     .|    ...|||::||.||:      
Human   467 LTWNSVKGKKSCHTAVDRTAGWNIPMGLLFNQTG-----SC----KFDEYFSQSCAPGS------ 516

  Fly   610 TGVPYDSMCDLCHGTSY--RYCRRDASEEYYGHTGAFRCLVEGGGHVAFMKHTTVMESTGGKRKE 672
              .|..::|.||.|...  ..|..:::|.|||:|||||||.|..|.|||:|..||:::|.|...|
Human   517 --DPRSNLCALCIGDEQGENKCVPNSNERYYGYTGAFRCLAENAGDVAFVKDVTVLQNTDGNNNE 579

  Fly   673 WWARNALNDDFELLCTDGTRAEIQDYKRCNLGKVKANAVVTRGGVNYNETQMNAYINLLTYAQQL 737
            .||::....||.|||.||.|..:.:.:.|:|.....:|||:|      ..::.....:|.:.|..
Human   580 AWAKDLKLADFALLCLDGKRKPVTEARSCHLAMAPNHAVVSR------MDKVERLKQVLLHQQAK 638

  Fly   738 YGRKEVDA-FSFSMFSSPIGHYDLIFQDATRQLQVIPPNKRRYDAYLGSDFM 788
            :||...|. ..|.:|.|..  .:|:|.|.|..|..: ..|..|:.|||..::
Human   639 FGRNGSDCPDKFCLFQSET--KNLLFNDNTECLARL-HGKTTYEKYLGPQYV 687

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Tsf2NP_524044.1 PBP2_transferrin 32..372 CDD:270247 101/359 (28%)
PBP2_transferrin 450..792 CDD:270247 116/358 (32%)
TR_FER 452..790 CDD:214514 116/356 (33%)
LTFNP_002334.2 Bactericidal and antifungal activity 20..29 1/16 (6%)
Critical for glycosaminoglycan, lipid A, lysozyme and DNA binding 20..24 0/11 (0%)