DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tsf2 and Tsf1

DIOPT Version :9

Sequence 1:	NP_524044.1	Gene:	Tsf2 / 39435	FlyBaseID:	FBgn0036299	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_001285404.1	Gene:	Tsf1 / 32821	FlyBaseID:	FBgn0022355	Length:	641	Species:	Drosophila melanogaster

Alignment Length:	799	Identity:	162/799 - (20%)
Similarity:	270/799 - (33%)	Gaps:	243/799 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 KCQNLTVAIERDRALFD--EVFLNLTCFMAYSADECIHHIDREKAHITTLDAGDVFTA------- 100
            :||.|         |.|  |..:.:.|.......:|:..|::.||.:...:..|::.|
  Fly    45 ECQQL---------LADPSEAGIRMECVAGRDRVDCLELIEQRKADVLATEPEDMYIAYHRKNED 100

  Fly   101 GRYNSLIPIMQEKLEGGFADYQSVAVIKKGSLPDLNNLRDMRNKRVCFPWVGSLAGWIVPI---- 161
            .|..|.|...|:| :..|. |:.:.::||.|  .:..|:.:|..:.|....|...|:.:||
  Fly   101 YRVISEIRTQQDK-DAAFR-YEGIILVKKDS--PIRTLQQLRGAKSCHTGFGRNVGYKIPITKLK 161

  Fly   162 --HTLQREGGMEVVDCNNQVKTAASYFNNSCAVYSLSDKHNPIGDNSDK-----LCTLCTGKIPG 219
              |.|:.....::.....::|:.:.:|..||.|.:.|.  :|..|...|     ||.||.   ..
  Fly   162 NTHVLKVSADPQISATERELKSLSEFFTQSCLVGTYST--HPETDRLLKKKYANLCALCE---KP 221

  Fly   220 GRCSSADPYFGYEGAFKCLLE-KGDVAFLRHSTVNEMLQTTEFKNIAPD---------TFELLCR 274
            .:|:..|.:.||:||.:||.: :|:|||   |.|..:.:........||         .||.||.
  Fly   222 EQCNYPDKFSGYDGAIRCLDKGQGEVAF---SKVQYIKKYFGLPGAGPDAPPAEGNPENFEYLCE 283

  Fly   275 DGRRASINDYRQCNWGQVPADAIVTSSARSFSDRKQYQQFLKRIAELYSDGTRDDQSRQGGQSFN 339
            ||.|..:.. ..|:|.|.|....: |:.::..:.:|..|...|:...:::|.
  Fly   284 DGTRRPVTG-PACSWAQRPWSGYI-SNEQAVHNSEQLHQLQSRLERFFANGL------------- 333

  Fly   340 SRNNINDQNAYGQFDNNDPYRTQNQYDQYRSERLDSSFAEERNQQDGTNTSILYEKFRIFESKRY 404
                        |..|.|                             ....:|.:...::.||..
  Fly   334 ------------QAQNKD-----------------------------AAAHLLIQPNAVYHSKDA 357

  Fly   405 GKPNLLFQDSSRALTVIPEDDQSFTKYLGPAINFIYGIRECPVPAMTLCVTSENELDKCIKMRTA 469
            .....::.:.:....||..|..:..|                   :.||..:::|..||..:..|
  Fly   358 AIDPKVYLERAGYKDVIERDGSAIRK-------------------IRLCAQNDDEFAKCQALHQA 403

  Fly   470 LKAHLLKPELICKKMHSHINCMQFIEAGKADISVFDAGDVYTGGLNYDLVPFMSEVYNLGEPEYY 534
            ..|...:|||.|.:   ..:|:..:...:||:::..|.. |....:..|.|.   ||.....:..
  Fly   404 AYARDARPELECVQ---STDCVVALTKKEADLTIVRATG-YADARSNQLQPI---VYEQRAQDDV 461

  Fly   535 VVAVAKEDDPDTELTYLKGKNTCHTGINTAAGWTYPMAL------FISNGWIRPYGCDSVRAAAE 593
            :||||                        |.|.|.. ||      |..|       |:..||||.
  Fly   462 LVAVA------------------------APGVTRE-ALQKASIKFNEN-------CERSRAAAA 494

  Fly   594 YFTKSCVPGAISNEYNTGVPYDSMCDLCHGTSYRYCRRDASEEYYGHTGAFRCLVEGGGHVAFMK 658
            ...|           ..|:  |:            ||..:|::               |.|..
  Fly   495 LLNK-----------RRGL--DA------------CRVSSSDD---------------GEVQI-- 517

  Fly   659 HTTVMESTGGKRKEWWARNALNDDFELLCTDGTRAEIQDYKRCNLGKVKANAVVTRGGVNYNETQ 723
               |..|...|.|          |.:|:|....|..:.|::.||:......|:..|.  :....:
  Fly   518 ---VPASELEKHK----------DAQLVCPSLERRPVTDFRDCNVDVQLPRAIFIRS--DTTSVE 567

  Fly   724 MNAYINLLTYAQQLYGR--KEVDAFS-FSMFSSPIGHYDLIFQDATRQLQVIPPNKRRYDAYLGS 785
            .....:|.:.....:|.  |.||.|: |..|..  |..::.|.|...||          ...|.:
  Fly   568 QETVKHLFSLISDKFGARGKLVDVFALFGEFQK--GKKNVYFNDKAVQL----------TTELKN 620

  Fly   786 DFMRARRITDCYAGASQLA 804
            :....:..||....|:::|
  Fly   621 EIQNEQIYTDLQCNANKIA 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tsf2	NP_524044.1	PBP2_transferrin	32..372	CDD:270247	80/356 (22%)
		PBP2_transferrin	450..792	CDD:270247	71/350 (20%)
		TR_FER	452..790	CDD:214514	71/346 (21%)
Tsf1	NP_001285404.1	PBP2_transferrin	34..>302	CDD:270247	71/278 (26%)
		Periplasmic_Binding_Protein_Type_2	384..615	CDD:304360	70/338 (21%)
		TR_FER	384..614	CDD:214514	68/327 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28KI0
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7803
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D102723at6656
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11485
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.870