DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tsf2 and RGD1310507

DIOPT Version :9

Sequence 1:	NP_524044.1	Gene:	Tsf2 / 39435	FlyBaseID:	FBgn0036299	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	XP_038937483.1	Gene:	RGD1310507 / 315963	RGDID:	1310507	Length:	715	Species:	Rattus norvegicus

Alignment Length:	822	Identity:	249/822 - (30%)
Similarity:	348/822 - (42%)	Gaps:	190/822 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VALVGA-----LCFTLANAQHHYDEHKTTRMVWCTKSQAEQYKCQNLTVAIERD--RALFDEVFL 65
            |:|.|:     ||..:        ..||.|  ||..|..|..||.:.     ||  :.:......
  Rat    20 VSLPGSHIRNRLCLAV--------PEKTIR--WCIVSDHEATKCSSF-----RDNMKKVLPAGGP 69

  Fly    66 NLTCFMAYSADECIHHIDREKAHITTLDAGDVFTAG-RYNSLIPIMQEKLEGGFAD-----YQSV 124
            .:.|....|..|||..|...|....|:|...|..|. .::||.|||.|..  |..|     |..|
  Rat    70 AVACVRKTSHLECIRDISANKIDAVTVDGALVAEADLPHHSLKPIMAEYY--GSKDDPQTHYYVV 132

  Fly   125 AVIKKGSLPDLNNLRDMRNKRVCFPWVGSLAGWIVPIHTLQREGGMEVVDCNNQVKTAASYFNNS 189
            ||:|||:...||.|   :.|:.|...:|..|||.||:..|...|..|.        .||::|::|
  Rat   133 AVVKKGTGFQLNQL---QGKKSCHASLGWSAGWYVPLSVLLPSGSRET--------AAATFFSSS 186

  Fly   190 CAVYSLSDKHNPIGDNS--DKLCTLCTGKIPGG----RCSSADPYFGYEGAFKCLLE-KGDVAFL 247
            |.         |..|..  .:||.||:||   |    .|||.:|||||.||.|||.: .|||:|:
  Rat   187 CV---------PCADGKMFPRLCQLCSGK---GTDKCSCSSGEPYFGYWGALKCLQDGTGDVSFV 239

  Fly   248 RHSTVNEMLQTTEFKNIAPDTFELLCRDGRRASINDYRQCNWGQVPADAIVTSSARSFSDRKQYQ 312
            ||.||.|::.    :....|.:||||.|..|..:::|.||...:||:..:|   |||...::...
  Rat   240 RHLTVFEVMP----RKADRDQYELLCPDNTRRPVDEYEQCYLARVPSHVVV---ARSVDGKEDSI 297

  Fly   313 QFLKRIAELYSDGTRDDQSRQGGQSFNSRNNINDQNAYGQFDNNDPYRTQNQYDQYRSERLDSSF 377
            |.|.|:|                           |..:|
  Rat   298 QELLRVA---------------------------QEHFG-------------------------- 309

  Fly   378 AEERNQQDGTNTSILYEKFRIFESKRYGKPNLLFQDSSRALTVIPEDDQSFTKYLGPAINFIYGI 442
                  :|.::|      |::|.|. :|| :|||.|::..|..:| .......|||  ...:..|
  Rat   310 ------KDKSST------FQLFGSP-HGK-DLLFTDAACGLLRVP-PKMDIGLYLG--YELLSAI 357

  Fly   443 RECPVPA-----MTLCVTSENELDKCIKMRTALKAHLLKPELICKKMHSHINCMQFIEAGKADIS 502
            |.....:     :..|...:.|..||.........     .|.|....:..:|:..:..|:||..
  Rat   358 RNLKRGSEDSRRVKWCAVGQQERAKCDHWSAVSGG-----ALACATEETPEDCIAAVMKGEADAV 417

  Fly   503 VFDAGDVYTGGLNYDLVPFMSEVY--------------NLGEPEYYVVAVAKEDDPDTELTYLKG 553
            ..|.|..|..| :..|||.:.|.|              |.....||||||.|:.|.......|:|
  Rat   418 NLDGGFAYIAG-HCGLVPGLGENYLSPHSSERLGSKCVNAALEGYYVVAVVKKSDVGITWNSLQG 481

  Fly   554 KNTCHTGINTAAGWTYPMALFISNGWIRPYGCDSVRAAAEYFTKSCVPGAISNEYNTGVPYDSMC 618
            |.:|||.:.|:|||..||:|.        |.........|:|:..|.|||        .|...:|
  Rat   482 KKSCHTAVGTSAGWNVPMSLI--------YNQTGSCKFDEFFSGGCAPGA--------NPDSRLC 530

  Fly   619 DLCHGTS--YRYCRRDASEEYYGHTGAFRCLVEGGGHVAFMKHTTVMESTGGKRKEWWARNALND 681
            .||.|.:  ...|..:..|.|:|.:||.||||| .|.||||||.||:::|.||..|.||:...::
  Rat   531 ALCAGGNEPAHMCAANNDEGYHGSSGALRCLVE-KGDVAFMKHPTVLQNTDGKNPESWAKGLKHE 594

  Fly   682 DFELLCTDGTRAEIQDYKRCNLGKVKANAVVTRGGVNYNETQMNAYINLLTYAQQLYGRKEVDAF 746
            ||||||.||||..:.:.:.|:|.:|..:||.:|      :.:::....:|...|:|:||...:..
  Rat   595 DFELLCLDGTRKPVTEAQNCHLDRVPNHAVFSR------KDKVDFVQRMLFNQQELFGRNGFEYR 653

  Fly   747 SFSMFSSPIGHYDLIFQDATRQLQVIPPNKRRYDAYLGSDFM 788
            .|.||.|  .|.||:|.|.|..|..: .||..|..|||..::
  Rat   654 MFQMFES--SHKDLLFSDDTECLSNL-QNKATYKTYLGPQYL 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tsf2	NP_524044.1	PBP2_transferrin	32..372	CDD:270247	107/354 (30%)
		PBP2_transferrin	450..792	CDD:270247	117/355 (33%)
		TR_FER	452..790	CDD:214514	117/353 (33%)
RGD1310507	XP_038937483.1	PBP2_transferrin_N	39..361	CDD:270336	126/430 (29%)
RGD1310507	XP_038937483.1	PBP2_transferrin_C	367..699	CDD:270335	117/358 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343051
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28KI0
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125278at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm45017
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11485
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1208
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.850