DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tsf2 and Meltf

DIOPT Version :9

Sequence 1:	NP_524044.1	Gene:	Tsf2 / 39435	FlyBaseID:	FBgn0036299	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_001099342.1	Gene:	Meltf / 288038	RGDID:	1308155	Length:	738	Species:	Rattus norvegicus

Alignment Length:	820	Identity:	269/820 - (32%)
Similarity:	387/820 - (47%)	Gaps:	150/820 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 MVWCTKSQAEQYKCQNLTVAIERDRALFDEVFLNLTCFMAYSADECIHHIDREKAHITTLDAGDV 97
            |.|||.|..||.||::::.|.:.     ..:..:|.|....|.|.|:..|..:||...|||.|.:
  Rat    23 MQWCTISDPEQQKCKDMSKAFQG-----AGIQPSLLCVQGTSTDHCVQLIKDQKADAITLDGGAI 82

  Fly    98 FTAGRYNSLIPIMQEKLEGGF-ADYQSVAVIKKGSLPDLNNLRDMRNKRVCFPWVGSLAGWIVPI 161
            :.||:...|.|::.|..:... ..|.:|||:::.|...:|.|:.:::   |...:....||.||:
  Rat    83 YQAGKEYGLKPVVGEVYDQDIGTSYYAVAVVRRNSNVTINTLKGVKS---CHTGINRTVGWNVPV 144

  Fly   162 HTLQREGGMEVVDCNNQVKTAASYFNNSCAVYSLSDKHNPIGDNSDKLCTLCTGKIPGGRCSSAD 226
            ..|...|.:.|:.| :.:|....||..||...:....|      |:.||.||.|...|.......
  Rat   145 GYLVETGHLSVMGC-DVLKAVGDYFGGSCVPGAGETSH------SESLCRLCRGDSSGHNVCDKS 202

  Fly   227 P---YFGYEGAFKCLLE-KGDVAFLRHSTVNEMLQTTEFKN-------IAPDTFELLCRDGRRAS 280
            |   |:.|.|||:||.| .|||||::||||   |:.|:.|.       :....|:||||||.||.
  Rat   203 PLERYYDYSGAFRCLAEGAGDVAFVKHSTV---LENTDGKTLPSWGKALMSQDFQLLCRDGSRAD 264

  Fly   281 INDYRQCNWGQVPADAIVTSSARSFSDRKQYQQFLKRIAELYSDGTRDDQSRQGGQSFNSRNNIN 345
            |.::|:|:..:|||.|:|                           .|||.  .||..|...|.
  Rat   265 ITEWRRCHLAKVPAHAVV---------------------------VRDDM--DGGLIFRLLNE-- 298

  Fly   346 DQNAYGQ--FDNNDPYRTQNQYDQYRSERLDSSFAEERNQQDGTNTSILYEKFRIFESKRYGKPN 408
                 ||  |.:.|                                    ..|::|.||.||:.|
  Rat   299 -----GQLLFSHED------------------------------------SSFQMFSSKAYGQKN 322

  Fly   409 LLFQDSSRALTVIPEDDQSFTKYLGPA-INFIYGIRECP--VP-AMTLCVTSENELDKCIKMRTA 469
            |||:||:  |.::|...|::..:||.. ::.:.|:...|  :| .:..||.|..|:.||..|..|
  Rat   323 LLFKDST--LELVPIATQNYESWLGQEYLHAMKGLLCDPNRLPHYLRWCVLSVPEIQKCGDMAVA 385

  Fly   470 LKAHLLKPELICKKMHSHINCMQFIEAGKADISVFDAGDVYTGGLNYDLVPFMSEVYNLGEPE-- 532
            .....||||:.|....|..:|||.|:||..|.......|:|..|..|.|||...|:|  .|.:
  Rat   386 FSRQSLKPEIQCVSAESPEHCMQQIQAGHIDAVTLRGEDIYRAGKAYGLVPAAGELY--AEEDRS 448

  Fly   533 --YYVVAVAKEDDP-DTELTYLKGKNTCHTGINTAAGWTYPMALFISNGWIRPYGCDSVRAAAEY 594
              |:||||.:.|.. ...|..|:.|.:||.|:.:.|||..|:...|..|:|||..||.:.|.:|:
  Rat   449 NSYFVVAVVRRDSSYSFTLDELRSKRSCHPGLGSPAGWEVPIGSLIQRGFIRPKDCDVLTAVSEF 513

  Fly   595 FTKSCVPGAISNEYNTGVPY-DSMCDLCHG--TSYRYCRRDASEEYYGHTGAFRCLVEGGGHVAF 656
            |..||||  ::|..|    | .|:|.||.|  .....|...:.|.|||::||||||||..|.|||
  Rat   514 FNASCVP--VNNPKN----YPSSLCALCVGDEKGRNKCVGSSQERYYGYSGAFRCLVENAGDVAF 572

  Fly   657 MKHTTVMESTGGKRKEWWARNALNDDFELLCTDGTRAEIQDYKRCNLGKVKANAVVTRGGVNYNE 721
            :|||||.|:|.|...|.||.:....|:||||.:|.|||:..::.|||.::.::||:.     :.:
  Rat   573 LKHTTVFENTNGHNPEPWASHLRWQDYELLCPNGARAEVDQFQACNLAQMPSHAVMV-----HPD 632

  Fly   722 TQMNAYINLLTYAQQLYGRKEVDAFSFSMFSSPIGH-YDLIFQDATRQLQVIP-PNKRRYDAYLG 784
            |.:.....||..||.|:| .:.:...|.||.|...| .||:|:|||  ::.:| ..|..|..:||
  Rat   633 TNIFTVYGLLDKAQDLFG-DDHNKNGFQMFDSSKYHSQDLLFKDAT--VRAVPVREKTTYLDWLG 694

  Fly   785 SDFMRARR--ITDCYAGASQ------------LALSVGLL 810
            .|::.|..  ::...:||..            |||:.|||
  Rat   695 PDYVVALEGMLSQQCSGAGAAVHRVPPPALLLLALAAGLL 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tsf2	NP_524044.1	PBP2_transferrin	32..372	CDD:270247	105/352 (30%)
		PBP2_transferrin	450..792	CDD:270247	136/351 (39%)
		TR_FER	452..790	CDD:214514	135/347 (39%)
Meltf	NP_001099342.1	PBP2_transferrin	23..355	CDD:270247	122/423 (29%)
		Transferrin	24..357	CDD:278817	122/424 (29%)
		TR_FER	367..704	CDD:214514	136/352 (39%)
		Periplasmic_Binding_Protein_Type_2	367..701	CDD:304360	135/349 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	237	1.000	Domainoid score	I2246
eggNOG	1	0.900	-	-		E1_28KI0
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4335
Inparanoid	1	1.050	389	1.000	Inparanoid score	I1937
OMA	1	1.010	-	-		QHG45906
OrthoDB	1	1.010	-	-		D125278at33208
OrthoFinder	1	1.000	-	-		FOG0007989
OrthoInspector	1	1.000	-	-		otm45017
orthoMCL	1	0.900	-	-		OOG6_106912
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1208
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.740