DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tsf2 and Tf

DIOPT Version :9

Sequence 1:	NP_524044.1	Gene:	Tsf2 / 39435	FlyBaseID:	FBgn0036299	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_001013128.1	Gene:	Tf / 24825	RGDID:	3845	Length:	698	Species:	Rattus norvegicus

Alignment Length:	827	Identity:	247/827 - (29%)
Similarity:	361/827 - (43%)	Gaps:	196/827 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SLVFVALVGALCFTLANAQHHYDEHKTTRMVWCTKSQAEQYKC----QNLTVAIERDRALFDEVF 64
            :|:..|.:| ||..:.:        ||.:  ||..|:.|..||    .::...:..|..
  Rat     7 ALLACAALG-LCLAVPD--------KTVK--WCAVSEHENTKCISFRDHMKTVLPADGP------ 54

  Fly    65 LNLTCFMAYSADECIHHIDREKAHITTLDAGDVFTAG-RYNSLIPIMQE---KLEGGFADYQSVA 125
             .|.|....|..:||..|...:|...|||.|.|:.|| ..|:|.|:..|   .||.....|.:||
  Rat    55 -RLACVKKTSYQDCIKAISGGEADAITLDGGWVYDAGLTPNNLKPVAAEFYGSLEHPQTHYLAVA 118

  Fly   126 VIKKGSLPDLNNLRDMRNKRVCFPWVGSLAGWIVPIHTLQREGGMEVVDCN------NQVKTAAS 184
            |:|||:...||.|   :.|:.|...:|..||||:||..|         .||      ...|..||
  Rat   119 VVKKGTDFQLNQL---QGKKSCHTGLGRSAGWIIPIGLL---------FCNLPEPRKPLEKAVAS 171

  Fly   185 YFNNSCAVYSLSDKHNPIGD--NSDKLCTLCTGKIPGGRCSSADPYFGYEGAFKCLLE-KGDVAF 246
            :|:.||.         |..|  ...:||.||    ||..||...|:|||.||||||.: .|||||
  Rat   172 FFSGSCV---------PCADPVAFPQLCQLC----PGCGCSPTQPFFGYVGAFKCLRDGGGDVAF 223

  Fly   247 LRHSTVNEMLQTTEFKNIAPDTFELLCRDGRRASINDYRQCNWGQVPADAIVTSSARSFSDRKQ- 310
            ::|:|:.|:|.    :....|.:||||.|..|..::.|..|...::|:.|:|   ||: .|.|:
  Rat   224 VKHTTIFEVLP----QKADRDQYELLCLDNTRKPVDQYEDCYLARIPSHAVV---ARN-GDGKED 280

  Fly   311 -YQQFLKRIAELYSDGTRDDQSRQGGQSFNSRNNINDQNAYGQFDNNDPYRTQNQYDQYRSERLD 374
             ..:.||...|.:..|...|
  Rat   281 LIWEILKVAQEHFGKGKSKD--------------------------------------------- 300

  Fly   375 SSFAEERNQQDGTNTSILYEKFRIFESKRYGKPNLLFQDSSRALTVIPEDDQSFTKYLGPAINFI 439
                                 |::|.|. .|| :|||:||:..|..:| ....:..|||.  :::
  Rat   301 ---------------------FQLFGSP-LGK-DLLFKDSAFGLLRVP-PRMDYRLYLGH--SYV 339

  Fly   440 YGIRE-----CPVPA-----MTLCVTSENELDKCIKMRTALKAHLLKPELICKKMHSHINCMQFI 494
            ..||.     ||..:     :..|..|..|..||.:...:...     ::.|:...|..:|:..|
  Rat   340 TAIRNQREGVCPEGSIDSAPVKWCALSHQERAKCDEWSVSSNG-----QIECESAESTEDCIDKI 399

  Fly   495 EAGKADISVFDAGDVYTGGLNYDLVPFMSEVYNLG---EPE-------YYVVAVAKEDDPDTELT 549
            ..|:||....|.|..|..| ...|||.|:|.|::.   .|:       ||.|||.|..|......
  Rat   400 VNGEADAMSLDGGHAYIAG-QCGLVPVMAENYDISSCTNPQSDVFPKGYYAVAVVKASDSSINWN 463

  Fly   550 YLKGKNTCHTGINTAAGWTYPMALFISNGWIRPYGCDSVRAAAEYFTKSCVPGAISNEYNTGVPY 614
            .||||.:||||::..|||..||.|..|    |...|    ...|:|::.|.||...|
  Rat   464 NLKGKKSCHTGVDRTAGWNIPMGLLFS----RINHC----KFDEFFSQGCAPGYKKN-------- 512

  Fly   615 DSMCDLCHGTSYRYCRRDASEEYYGHTGAFRCLVEGGGHVAFMKHTTVMESTGGKRKEWWARNAL 679
            .::||||.|.:  .|..:..|.|.|:||||:|||| .|.|||:||.||:|:|.||....||::..
  Rat   513 STLCDLCIGPA--KCAPNNREGYNGYTGAFQCLVE-KGDVAFVKHQTVLENTNGKNTAAWAKDLK 574

  Fly   680 NDDFELLCTDGTRAEIQDYKRCNLGKVKANAVVTRGGVNYNETQMNAYINLLTYAQQLYGRKEVD 744
            .:||:|||.|||:..:.::..|:|.:...:.||:|      :.:......:||..:.|:.:.:.|
  Rat   575 QEDFQLLCPDGTKKPVTEFATCHLAQAPNHVVVSR------KEKAARVSTVLTAQKDLFWKGDKD 633

  Fly   745 AF-SFSMFSSPIGHYDLIFQDATRQLQVIPPNKRRYDAYLGSDFMRA 790
            .. :|.:|.|  ...||:|:|.|:.|..:|.. ..|:.|||:::::|
  Rat   634 CTGNFCLFRS--STKDLLFRDDTKCLTKLPEG-TTYEEYLGAEYLQA 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tsf2	NP_524044.1	PBP2_transferrin	32..372	CDD:270247	105/358 (29%)
		PBP2_transferrin	450..792	CDD:270247	116/352 (33%)
		TR_FER	452..790	CDD:214514	115/348 (33%)
Tf	NP_001013128.1	PBP2_transferrin_N	24..346	CDD:270336	123/434 (28%)
		Transferrin	25..347	CDD:278817	122/434 (28%)
		PBP2_transferrin_C	357..682	CDD:270335	116/355 (33%)
		TR_FER	360..683	CDD:214514	116/352 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125278at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm45017
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11485
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1208
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.020