DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tsf2 and Ltf

DIOPT Version :9

Sequence 1:	NP_524044.1	Gene:	Tsf2 / 39435	FlyBaseID:	FBgn0036299	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_032548.2	Gene:	Ltf / 17002	MGIID:	96837	Length:	707	Species:	Mus musculus

Alignment Length:	837	Identity:	239/837 - (28%)
Similarity:	355/837 - (42%)	Gaps:	194/837 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SLVFVALVGALCFTLANAQHHYDEHKTTRMVWCTKSQAEQYKC---QNLTVAIERDRALFDEVFL 65
            ||:|:..:| ||..           |.|.:.||..|.:|:.||   ||....:...
Mouse     7 SLIFLEALG-LCLA-----------KATTVQWCAVSNSEEEKCLRWQNEMRKVGGP--------- 50

  Fly    66 NLTCFMAYSADECIHHIDREKAHITTLDAGDVFTAGR--YNSLIPIMQE---KLEGGFADYQSVA 125
            .|:|....|..:||..|...:|...|||.|.:|.||:  | .|.|:..|   ..|.....|.:||
Mouse    51 PLSCVKKSSTRQCIQAIVTNRADAMTLDGGTMFDAGKPPY-KLRPVAAEVYGTKEQPRTHYYAVA 114

  Fly   126 VIKKGSLPDLNNLRDMRNKRVCFPWVGSLAGWIVPIHTLQREGGMEVVDCNN---QVKTAAS-YF 186
            |:|..|...||.|:.:|:   |...:|..|||.:||.||:     ..::.|.   .::.|.| :|
Mouse   115 VVKNSSNFHLNQLQGLRS---CHTGIGRSAGWKIPIGTLR-----PYLNWNGPPASLEEAVSKFF 171

  Fly   187 NNSCAVYSLSDKHNPIGDNSDKLCTLCTGKIPGGRCSSA--DPYFGYEGAFKCLLEK-GDVAFLR 248
            :.||...:..|:.       ..||:.|.| ....:|:|:  :||.||.||.:||.:. |||||.|
Mouse   172 SKSCVPGAQKDRF-------PNLCSSCAG-TGANKCASSPEEPYSGYAGALRCLRDNAGDVAFTR 228

  Fly   249 HSTVNEMLQTTEFKNIAP-DTFELLCRDGRRASINDYRQCNWGQVPADAIVTSSARSFSDRKQYQ 312
            .|||.|     |..|.|. |.::|||.|.....:.:|::|:..|||:.|:|   :||.:|:::
Mouse   229 GSTVFE-----ELPNKAERDQYKLLCPDNTWKPVTEYKECHLAQVPSHAVV---SRSTNDKEE-- 283

  Fly   313 QFLKRIAELYSDGTRDDQSRQGGQSFNSRNNINDQNAYGQFDNNDPYRTQNQYDQYRSERLDSSF 377
                .|.||.         ||..:.|.
Mouse   284 ----AIWELL---------RQSQEKFG-------------------------------------- 297

  Fly   378 AEERNQQDGTNTSILYEKFRIFESKRYGKPNLLFQDSSRALTVIPEDDQSFTKYLGPAINFIY-- 440
               :.|..|         |::|.|.. |:.:|||::|:.....:|:...     :|..:.|.|
Mouse   298 ---KKQASG---------FQLFASPS-GQKDLLFKESAIGFVRVPQKVD-----VGLYLTFSYTT 344

  Fly   441 -----GIRECPVPA----MTLCVTSENELDKCIKMRTALKAHLLKPELICKKMHSHINCMQFIEA 496
                 ..::..|.|    :|.|.....|..||.:...|.:.     .:.|....:..:|:..|..
Mouse   345 SIQNLNKKQQDVIASKARVTWCAVGSEEKRKCDQWNRASRG-----RVTCISFPTTEDCIVAIMK 404

  Fly   497 GKADISVFDAGDVYTGGLNYDLVPFMSE-----------VYNLGEPEYYVVAVAKEDDPDTELTY 550
            |.||....|.|.:||.| ...|||.::|           ..|.....|..||..:.:|.....:.
Mouse   405 GDADAMSLDGGYIYTAG-KCGLVPVLAENQKSSKSNGLDCVNRPVEGYLAVAAVRREDAGFTWSS 468

  Fly   551 LKGKNTCHTGINTAAGWTYPMALFISNGWIRPYGCDSVRAAA--EYFTKSCVPGAISNEYNTGVP 613
            |:||.:|||.::..|||..||.|.          .:..|:..  |:|::||.|||        .|
Mouse   469 LRGKKSCHTAVDRTAGWNIPMGLL----------ANQTRSCKFNEFFSQSCAPGA--------DP 515

  Fly   614 YDSMCDLCHG--TSYRYCRRDASEEYYGHTGAFRCLVEGGGHVAFMKHTTVMESTGGKRKEWWAR 676
            ..::|.||.|  .....|..::.|.|.|:|||.|||.|..|:|||:|.:||:::|.||..|.|||
Mouse   516 KSNLCALCIGDEKGENKCAPNSKERYQGYTGALRCLAEKAGNVAFLKDSTVLQNTDGKNTEEWAR 580

  Fly   677 NALNDDFELLCTDGTRAEIQDYKRCNLGKVKANAVVTRGGVNYNETQMNAYINLLTYAQQLYGRK 741
            |....||||||.|.||..:.:.|.|:|.....:|||:|      ..::.....:|...|..:||.
Mouse   581 NLKLKDFELLCLDDTRKPVTEAKNCHLAIAPNHAVVSR------TDKVEVLQQVLLDQQVQFGRN 639

  Fly   742 -EVDAFSFSMFSSPIGHYDLIFQDATRQLQVIPPNKRRYDAYLGSDFMRA-RRITDC 796
             :.....|.:|.|..  .:|:|.|.|..|..| |.|...:.|||.:::.| .|:..|
Mouse   640 GQRCPGEFCLFQSKT--KNLLFNDNTECLAKI-PGKTTSEKYLGKEYVIATERLKQC 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tsf2	NP_524044.1	PBP2_transferrin	32..372	CDD:270247	101/355 (28%)
		PBP2_transferrin	450..792	CDD:270247	112/358 (31%)
		TR_FER	452..790	CDD:214514	110/353 (31%)
Ltf	NP_032548.2	PBP2_transferrin_N	23..349	CDD:270336	115/430 (27%)
		Transferrin	24..351	CDD:278817	115/431 (27%)
		PBP2_transferrin_C	361..691	CDD:270335	113/362 (31%)
		TR_FER	363..692	CDD:214514	113/361 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28KI0
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125278at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42949
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11485
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7331
SonicParanoid	1	1.000	-	-		X1208
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.910