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Protein Alignment nst and PGM2

DIOPT Version :9

Sequence 1:	NP_648588.1	Gene:	nst / 39434	FlyBaseID:	FBgn0036298	Length:	549	Species:	Drosophila melanogaster
Sequence 2:	NP_060760.2	Gene:	PGM2 / 55276	HGNCID:	8906	Length:	612	Species:	Homo sapiens

Alignment Length:	560	Identity:	99/560 - (17%)
Similarity:	175/560 - (31%)	Gaps:	212/560 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 GVMITASHNPEPDNGVKLVDPKGEMLEASWEAIATDLVNVSDQELEQQVAKIIK-------DNNI 119
            |:||||||||:.|||.|:.          |:. ...:::..|:.:.|.:.:.::       |:.|
Human   159 GIMITASHNPKQDNGYKVY----------WDN-GAQIISPHDKGISQAIEENLEPWPQAWDDSLI 212

  Fly   120 DVTTSSQVFVGMDNRYHSPRLLKAVADGVIALKGNVKEYGIVTTPMLHYFVVAANTKEAYGKPTE 184
            |                                         ::|:||....:.|
Human   213 D-----------------------------------------SSPLLHNPSASIN---------- 226

  Fly   185 EGYYDKLIK-AFELLRNGRLENGNYRNSIIYDGANGVGARKMLQFIKRMKGTLNVTVINQGIGVG 248
            ..|::.|.| .|.     |..|...:...::...:|||...:....|..
Human   227 NDYFEDLKKYCFH-----RSVNRETKVKFVHTSVHGVGHSFVQSAFKAF---------------- 270

  Fly   249 KINEDCGADYVKVQQSPPKSMPEDVKPYTRCVSV------------------------------D 283
                    |.|     ||:::||...|.....:|                              |
Human   271 --------DLV-----PPEAVPEQKDPDPEFPTVKYPNPEEGKGVLTLSFALADKTKARIVLAND 322

  Fly   284 GDADRVVYFFTDDKGEFHLLDGDRIATLIAGYLMELVTQSEISLRLGLVQTAYANGASTDYIVDQ 348
            .||||:......|.||:.:..|:.:..|:..:|.....:.... |..|..|...:...:..|:..
Human   323 PDADRLAVAEKQDSGEWRVFSGNELGALLGWWLFTSWKEKNQD-RSALKDTYMLSSTVSSKILRA 386

  Fly   349 LK----FPVSCVPTGVKHLHHKALE-YDIG-----VYFEANGHGTIVF---SDNAKATI--AQVA 398
            :.    |......||.|.:.::|.: .|.|     .:.||.|:....|   .|...|.:  |::|
Human   387 IALKEGFHFEETLTGFKWMGNRAKQLIDQGKTVLFAFEEAIGYMCCPFVLDKDGVSAAVISAELA 451

  Fly   399 Q---TKESAKTLLLLIDLI----------------NETVGDAISDMLLVETILNHKGWD------ 438
            .   ||..:.:..|....:                .||:      ..|.|.:.|:.|.:
Human   452 SFLATKNLSLSQQLKAIYVEYGYHITKASYFICHDQETI------KKLFENLRNYDGKNNYPKAC 510

  Fly   439 -------VQDWISSYNDLPNRQLKVKVQDRNVIETTDAERVCVKPEGLQTEINQVVAKYKRGR-S 495
                   ::|..:.|:|                  :..::..|.|....:::  :...:..|. :
Human   511 GKFEISAIRDLTTGYDD------------------SQPDKKAVLPTSKSSQM--ITFTFANGGVA 555

  Fly   496 FVRPSGTEDVVRVYAEAAT---KEDTDNLAYEVGLLVQKL 532
            .:|.||||..::.|||...   ..|.:.|..|:..||..:
Human   556 TMRTSGTEPKIKYYAELCAPPGNSDPEQLKKELNELVSAI 595

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.