DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nst and pgm3

DIOPT Version :9

Sequence 1:	NP_648588.1	Gene:	nst / 39434	FlyBaseID:	FBgn0036298	Length:	549	Species:	Drosophila melanogaster
Sequence 2:	XP_021330676.1	Gene:	pgm3 / 474321	ZFINID:	ZDB-GENE-041024-13	Length:	579	Species:	Danio rerio

Alignment Length:	531	Identity:	289/531 - (54%)
Similarity:	365/531 - (68%)	Gaps:	11/531 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 EMYPKTSKETIQYGTAGFRGKAEFLDSVMFRMGVLATLRSRYRGGSVIGVMITASHNPEPDNGVK 78
            :::||....|:||||||||..|:.||.:|||||:||||||: :..|.||||:|||||||.|||||
Zfish    46 KLHPKPEGLTLQYGTAGFRTNAKHLDHIMFRMGLLATLRSK-KTKSTIGVMVTASHNPEEDNGVK 109

  Fly    79 LVDPKGEMLEASWEAIATDLVNVSDQELEQQVAKIIKDNNIDVTTSSQVFVGMDNRYHSPRLLKA 143
            |:||.|||:.|:||..||.|.|.....|...:..||:..:|.::.::.|::|.|.|..|..|.:|
Zfish   110 LIDPMGEMVAAAWEEYATQLANAEQDHLLAALKDIIEKEDISMSEAASVYIGRDTRPSSAALSQA 174

  Fly   144 VADGVIALKGNVKEYGIVTTPMLHYFVVAANTKEAYGKPTEEGYYDKLIKAFELLRNGRLENGNY 208
            |.|||.:|.|...:||:|:||.|||.|...|||..||..|.||||.||.:||..|.:......:.
Zfish   175 VLDGVSSLGGKTHDYGLVSTPQLHYMVCCCNTKGRYGSATLEGYYQKLSQAFLQLTHNVPNRTDD 239

  Fly   209 RNSIIYDGANGVGARKMLQFIKRMKGTLNVTVINQGIGVGKINEDCGADYVKVQQSPPKSMPEDV 273
            :..::.|||||:||.||.:....::..|.|.:.|.| ..||:|..||||||||||..|:.:...|
Zfish   240 QKRLLLDGANGIGALKMKELEPFIRSELQVVLSNDG-SSGKLNHLCGADYVKVQQKAPQGVSMGV 303

  Fly   274 KPYTRCVSVDGDADRVVYFFTDDKGEFHLLDGDRIATLIAGYLMELVTQSEISLRLGLVQTAYAN 338
            .  .||.|.||||||:||::||.|..|||||||:|||||:.:|.||:||:.::|::.:|||||||
Zfish   304 G--ERCCSFDGDADRIVYYYTDSKNCFHLLDGDKIATLISTFLKELLTQAGLNLQVAVVQTAYAN 366

  Fly   339 GASTDYIVDQLKFPVSCVPTGVKHLHHKALEYDIGVYFEANGHGTIVFSDNAKATIAQVA----- 398
            |:||.|:.|.:|..|.|..||||||||.|.|||||||||||||||::||..|:..|.::.
Zfish   367 GSSTRYLEDVMKVAVCCTKTGVKHLHHAAQEYDIGVYFEANGHGTVLFSKAAQKQIVELVKDSNV 431

  Fly   399 --QTKESAKTLLLLIDLINETVGDAISDMLLVETILNHKGWDVQDWISSYNDLPNRQLKVKVQDR 461
              :.|.:||.|...::|||:||||||||||::|.:|..:|..||||...|.|||||||||.|.||
Zfish   432 NDERKHAAKLLENTVNLINQTVGDAISDMLVIEAVLAIRGMSVQDWDEIYTDLPNRQLKVTVSDR 496

  Fly   462 NVIETTDAERVCVKPEGLQTEINQVVAKYKRGRSFVRPSGTEDVVRVYAEAATKEDTDNLAYEVG 526
            .||.||||||..|.|||||..|:.:|.|||..|||||||||||||||||||.|:|..|.||:||.
Zfish   497 RVINTTDAERRAVTPEGLQDAIDSLVKKYKNARSFVRPSGTEDVVRVYAEADTQEGADRLAHEVS 561

  Fly   527 LLVQKLAGGVG 537
            |.|.:||||||
Zfish   562 LAVHRLAGGVG 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nst	NP_648588.1	PLN02895	6..539	CDD:215485	289/531 (54%)
nst	NP_648588.1	PGM3	25..529	CDD:100088	279/510 (55%)
pgm3	XP_021330676.1	PGM3	57..564	CDD:100088	279/510 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573352
Domainoid	1	1.000	306	1.000	Domainoid score	I1334
eggNOG	1	0.900	-	-		E1_COG1109
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9205
Inparanoid	1	1.050	549	1.000	Inparanoid score	I1111
OMA	1	1.010	-	-		QHG56540
OrthoDB	1	1.010	-	-		D231157at33208
OrthoFinder	1	1.000	-	-		FOG0003921
OrthoInspector	1	1.000	-	-		oto39413
orthoMCL	1	0.900	-	-		OOG6_102413
Panther	1	1.100	-	-	LDO	PTHR45955
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2021
SonicParanoid	1	1.000	-	-		X2227
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800