DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nst and F21D5.1

DIOPT Version :9

Sequence 1:	NP_648588.1	Gene:	nst / 39434	FlyBaseID:	FBgn0036298	Length:	549	Species:	Drosophila melanogaster
Sequence 2:	NP_501500.1	Gene:	F21D5.1 / 177678	WormBaseID:	WBGene00009006	Length:	550	Species:	Caenorhabditis elegans

Alignment Length:	528	Identity:	237/528 - (44%)
Similarity:	318/528 - (60%)	Gaps:	26/528 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 ETIQYGTAGFRGKAEFLDSVMFRMGVLATLRSRYRGGSVIGVMITASHNPEPDNGVKLVDPKGEM 86
            |...|||||||.|:|.|..::||...:|:||:| :..|.|||||||||||..|||||||||.|:|
Worm    28 EKFSYGTAGFRFKSEKLPFIVFRCAYVASLRAR-QLNSAIGVMITASHNPSCDNGVKLVDPSGDM 91

  Fly    87 LEASWEAIATDLVNVSDQELEQQVAKIIKDNNIDVTTSSQVFVGMDNRYHSPRLLKAVADGVIAL 151
            |...||..||::||.:|.||...|..:.|..::..|..|:|..|||.|...|.|:.|...|....
Worm    92 LNEQWEIYATEVVNATDAELPAAVRALEKQISVGKTQLSRVVCGMDTRCSGPCLMNAARAGAALF 156

  Fly   152 KGNVKEYGIVTTPMLHYFVVAANTKEAYGKPTEEGYY----DKLIKAFELLRNGRLENGNYRNSI 212
            .....:.|:|:||||||.|.|.| :..:.:||.:|||    |...|.:|:....:  :..|:..:
Worm   157 NVQFDDIGVVSTPMLHYAVKAFN-EPKFAEPTHDGYYSAIADSFKKLYEITEEPK--DSRYQPKV 218

  Fly   213 IYDGANGVGARKMLQFIKRMKGT-LNVTVINQGIGVGKINEDCGADYVKVQQSPPKSM-PEDVKP 275
            |.|.||||||.:....::|:..: |.|...|:.   .::|:.||||:||:.|..|.:. |...:|
Worm   219 IVDCANGVGAPRFRNLLERIPSSLLEVEFRNES---EELNQGCGADFVKISQKLPANFSPTAAEP 280

  Fly   276 YTRCVSVDGDADRVVYF-----FTDDKGEFHLLDGDRIATLIAGYLMELVTQSEIS-----LRLG 330
              :|.|.||||||::||     ...:..:..|.|||:||.||..|:.|.:...|.|     ||||
Worm   281 --KCASFDGDADRLMYFRAKASENSESNDAELFDGDKIAVLIVTYIREQLKDYENSTPMERLRLG 343

  Fly   331 LVQTAYANGASTDYIVDQLKFPVSCVPTGVKHLHHKALEYDIGVYFEANGHGTIVFSDNAKATIA 395
            :||||||||:||.||.::|......|||||||||..|.|:|||:|||||||||:|||:.....|.
Worm   344 IVQTAYANGSSTRYIREKLGIEPIIVPTGVKHLHEAASEFDIGIYFEANGHGTVVFSEIFDRIIR 408

  Fly   396 QVAQTKESAKTLLLLIDLINETVGDAISDMLLVETILNHKGWDVQDWISS-YNDLPNRQLKVKVQ 459
            :........:.|.|...:||||||||.:|:|.||.:|.|.||.:.||... |.|:||.|:||.|.
Worm   409 RTPTESLPLRRLALFSRVINETVGDAFADLLAVEAVLRHYGWSMDDWAEKLYRDVPNVQIKVPVI 473

  Fly   460 DRNVIETTDAERVCVKPEGLQTEINQVVAKYKRGRSFVRPSGTEDVVRVYAEAATKEDTDNLAYE 524
            ||::.:||:||:..|||.|:|..|:..||||...|:|:||||||::|||||||.|.|:|..|...
Worm   474 DRSIFKTTNAEQTLVKPVGIQKMIDTDVAKYNNSRAFIRPSGTENIVRVYAEADTVENTLQLGKS 538

  Fly   525 VGLLVQKL 532
            :..:|..|
Worm   539 LEQVVLNL 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nst	NP_648588.1	PLN02895	6..539	CDD:215485	237/528 (45%)
nst	NP_648588.1	PGM3	25..529	CDD:100088	234/520 (45%)
F21D5.1	NP_501500.1	PLN02895	17..547	CDD:215485	237/528 (45%)
F21D5.1	NP_501500.1	PGM3	31..543	CDD:100088	234/520 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156050
Domainoid	1	1.000	54	1.000	Domainoid score	I7574
eggNOG	1	0.900	-	-		E1_COG1109
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9205
Inparanoid	1	1.050	410	1.000	Inparanoid score	I1051
Isobase	1	0.950	-	0	Normalized mean entropy	S876
OMA	1	1.010	-	-		QHG56540
OrthoDB	1	1.010	-	-		D231157at33208
OrthoFinder	1	1.000	-	-		FOG0003921
OrthoInspector	1	1.000	-	-		oto19990
orthoMCL	1	0.900	-	-		OOG6_102413
Panther	1	1.100	-	-	LDO	PTHR45955
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2021
SonicParanoid	1	1.000	-	-		X2227
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	16	15.790