DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nst and Pgm3

DIOPT Version :9

Sequence 1:	NP_648588.1	Gene:	nst / 39434	FlyBaseID:	FBgn0036298	Length:	549	Species:	Drosophila melanogaster
Sequence 2:	NP_082628.3	Gene:	Pgm3 / 109785	MGIID:	97566	Length:	542	Species:	Mus musculus

Alignment Length:	528	Identity:	280/528 - (53%)
Similarity:	361/528 - (68%)	Gaps:	9/528 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 MYPKTSKETIQYGTAGFRGKAEFLDSVMFRMGVLATLRSRYRGGSVIGVMITASHNPEPDNGVKL 79
            ::.|.....:||||||||..|:.||.:|||||:||.|||: :..|.||||:|||||||.||||||
Mouse    12 LHAKPQGLILQYGTAGFRTNAQHLDHIMFRMGLLAVLRSK-QTRSTIGVMVTASHNPEEDNGVKL 75

  Fly    80 VDPKGEMLEASWEAIATDLVNVSDQELEQQVAKIIKDNNIDVTTSSQVFVGMDNRYHSPRLLKAV 144
            |||.||||..|||..||.|.:..:|::.|.:|.|::...:|:|.::.|.:..|.|..|.:|.::|
Mouse    76 VDPLGEMLAPSWEEHATCLASAEEQDVRQVLAAIVEKEAVDLTQTAFVVIARDTRPSSEKLSQSV 140

  Fly   145 ADGVIALKGNVKEYGIVTTPMLHYFVVAANTKEAYGKPTEEGYYDKLIKAFELLRNGRLENGNYR 209
            .|||..|.|...:||::|||.|||.|...|:...||:.|.|||..||.|||..|.|....:|:.:
Mouse   141 IDGVTVLGGQFHDYGLLTTPQLHYMVYCRNSGGRYGQATVEGYCQKLSKAFVDLTNQVSCSGDVK 205

  Fly   210 NSIIYDGANGVGARKMLQFIKRMKGTLNVTVINQGIGVGKINEDCGADYVKVQQSPPKSMPEDVK 274
            .|:..|.|||:||.|:.:........|:|.:.|.|. .|::|..||||:||.||.||:.:  ::|
Mouse   206 RSVKVDCANGIGALKLREMEHYFSRGLSVLLFNDGT-QGRLNHLCGADFVKSQQKPPQGI--EMK 267

  Fly   275 PYTRCVSVDGDADRVVYFFTDDKGEFHLLDGDRIATLIAGYLMELVTQSEISLRLGLVQTAYANG 339
            ...||.|.||||||:||::.|..|.|||:|||:|||||:.:|.||:.:...|:.||:||||||||
Mouse   268 SGERCCSFDGDADRIVYYYCDADGHFHLIDGDKIATLISSFLKELLLEIGESVNLGVVQTAYANG 332

  Fly   340 ASTDYIVDQLKFPVSCVPTGVKHLHHKALEYDIGVYFEANGHGTIVFSDNAKATIAQVAQTKE-- 402
            :||.|:.:.:|.||.|..||||||||||.|:|||||||||||||.:||:..:..|.::||..:
Mouse   333 SSTRYLEEVMKVPVYCTKTGVKHLHHKAQEFDIGVYFEANGHGTALFSEAVEVKIKRLAQELDDG 397

  Fly   403 ---SAKTLLLLIDLINETVGDAISDMLLVETILNHKGWDVQDWISSYNDLPNRQLKVKVQDRNVI 464
               :|:||..:|||.|:..||||||||::|.||..||..||.|.:.|.|||||||||||.||.||
Mouse   398 KGKAARTLASIIDLFNQAAGDAISDMLVIEAILALKGLTVQQWDAIYVDLPNRQLKVKVADRRVI 462

  Fly   465 ETTDAERVCVKPEGLQTEINQVVAKYKRGRSFVRPSGTEDVVRVYAEAATKEDTDNLAYEVGLLV 529
            .||||||..|.|.|||..||.:|.||...|:|||||||||:|||||||.::|..|.|||||.|||
Mouse   463 STTDAERQAVTPPGLQEAINDLVKKYTLARAFVRPSGTEDIVRVYAEANSQESADRLAYEVSLLV 527

  Fly   530 QKLAGGVG 537
            .:||||:|
Mouse   528 FQLAGGIG 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nst	NP_648588.1	PLN02895	6..539	CDD:215485	280/528 (53%)
nst	NP_648588.1	PGM3	25..529	CDD:100088	272/508 (54%)
Pgm3	NP_082628.3	PLN02895	1..538	CDD:215485	280/528 (53%)
		PGM3	22..527	CDD:100088	272/508 (54%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q9P4V2	370..372		1/1 (100%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q9P4V2	496..500		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830623
Domainoid	1	1.000	272	1.000	Domainoid score	I1804
eggNOG	1	0.900	-	-		E1_COG1109
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9205
Inparanoid	1	1.050	528	1.000	Inparanoid score	I1215
Isobase	1	0.950	-	0	Normalized mean entropy	S876
OMA	1	1.010	-	-		QHG56540
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003921
OrthoInspector	1	1.000	-	-		oto95389
orthoMCL	1	0.900	-	-		OOG6_102413
Panther	1	1.100	-	-	LDO	PTHR45955
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2021
SonicParanoid	1	1.000	-	-		X2227
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740