DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF2beta and EIF2S2

DIOPT Version :9

Sequence 1:	NP_524043.1	Gene:	eIF2beta / 39433	FlyBaseID:	FBgn0004926	Length:	312	Species:	Drosophila melanogaster
Sequence 2:	NP_003899.2	Gene:	EIF2S2 / 8894	HGNCID:	3266	Length:	333	Species:	Homo sapiens

Alignment Length:	337	Identity:	188/337 - (55%)
Similarity:	226/337 - (67%)	Gaps:	46/337 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 FDPTLLKKKKKKKTTFDLDAALGLEDDTKKEDPQ--------------------DEASAEGGAAA 51
            ||||:.|||||||..|.||.    |.||:.|:.|                    :|.:.:..|:.
Human     8 FDPTMSKKKKKKKKPFMLDE----EGDTQTEETQPSETKEVEPEPTEDKDLEADEEDTRKKDASD 68

  Fly    52 EEDNLDLESFGKKKKKKKKPFNMDEIEAAIPSFG-GDDVAASEEPEEEEINLDMDFSMAKKKKKS 115
            :.|:|:..:..|||||.||.|::||.|..:.... ..||....|||:     |:|..:..||||.
Human    69 DLDDLNFFNQKKKKKKTKKIFDIDEAEEGVKDLKIESDVQEPTEPED-----DLDIMLGNKKKKK 128

  Fly   116 KKKELDELFADQAD----DDKSEDKENDEDN--------SSTWFGSDRDYTYDELLKRVFEIILD 168
            |..:    |.|:.:    |:..||::|.:|:        ...|.||:|||||:|||.|||.|:.:
Human   129 KNVK----FPDEDEILEKDEALEDEDNKKDDGISFSNQTGPAWAGSERDYTYEELLNRVFNIMRE 189

  Fly   169 KNPDMAAGRKPKFVMRPPQVLRVGTKKTSFANFMDIAKTLHRLPKHLLDFLLAELGTSGSMDGNQ 233
            |||||.||.|.||||:||||:|||||||||.||.||.|.|||.|||||.|||||||||||:|||.
Human   190 KNPDMVAGEKRKFVMKPPQVVRVGTKKTSFVNFTDICKLLHRQPKHLLAFLLAELGTSGSIDGNN 254

  Fly   234 QLIIKGRFQPKQIENVLRRYIKEYVTCHTCRSPETILQKDTRLFFLQCESCGSRCSVASIKSGFQ 298
            ||:||||||.|||||||||||||||||||||||:|||||||||:|||||:|.|||||||||:|||
Human   255 QLVIKGRFQQKQIENVLRRYIKEYVTCHTCRSPDTILQKDTRLYFLQCETCHSRCSVASIKTGFQ 319

  Fly   299 AVTGKRAAIRAK 310
            |||||||.:|||
Human   320 AVTGKRAQLRAK 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF2beta	NP_524043.1	eIF2B_5	178..287	CDD:214764	91/108 (84%)
EIF2S2	NP_003899.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..119		40/119 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..164		5/24 (21%)
		eIF2B_5	199..308	CDD:214764	91/108 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160044
Domainoid	1	1.000	193	1.000	Domainoid score	I3200
eggNOG	1	0.900	-	-		E1_COG1601
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2904
Inparanoid	1	1.050	337	1.000	Inparanoid score	I2395
Isobase	1	0.950	-	0	Normalized mean entropy	S817
OMA	1	1.010	-	-		QHG55888
OrthoDB	1	1.010	-	-		D1178655at2759
OrthoFinder	1	1.000	-	-		FOG0004439
OrthoInspector	1	1.000	-	-		oto90724
orthoMCL	1	0.900	-	-		OOG6_101265
Panther	1	1.100	-	-	LDO	PTHR23001
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R592
SonicParanoid	1	1.000	-	-		X3723
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750