DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF2beta and Eif2s2

DIOPT Version :9

Sequence 1:	NP_524043.1	Gene:	eIF2beta / 39433	FlyBaseID:	FBgn0004926	Length:	312	Species:	Drosophila melanogaster
Sequence 2:	NP_080306.1	Gene:	Eif2s2 / 67204	MGIID:	1914454	Length:	331	Species:	Mus musculus

Alignment Length:	329	Identity:	193/329 - (58%)
Similarity:	234/329 - (71%)	Gaps:	32/329 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 FDPTLLKKKKKKKTTFDLDAALGLE------DDTKKEDPQ----------DEASAEGGAAAEEDN 55
            ||||:.|||||||..|.||.....:      .:||:.:|:          :|.|.:..|:.:.|:
Mouse     8 FDPTMSKKKKKKKKPFMLDEEGDAQTEETQPSETKEVEPEPTEEKDVDADEEDSRKKDASDDLDD 72

  Fly    56 LDLESFGKKKKKKKKPFNMDEIEAAIPSFGGDDV---AASEEPEEEEINLDMDFSMAKKKKKSKK 117
            |:..:..|||||.||.|::||.|.||     .||   :.::||.|.|.:||:.....|||||:.|
Mouse    73 LNFFNQKKKKKKTKKIFDIDEAEEAI-----KDVKIESDAQEPAEPEDDLDIMLGNKKKKKKNVK 132

  Fly   118 -KELDELF-ADQADDDKSEDKENDE----DNSSTWFGSDRDYTYDELLKRVFEIILDKNPDMAAG 176
             .|.||:. .|:|.:|  ||.:.|:    .:.:.|.||:|||||:|||.|||.|:.:|||||.||
Mouse   133 FPEEDEILEKDEALED--EDSKKDDGISFSSQTAWAGSERDYTYEELLNRVFNIMREKNPDMVAG 195

  Fly   177 RKPKFVMRPPQVLRVGTKKTSFANFMDIAKTLHRLPKHLLDFLLAELGTSGSMDGNQQLIIKGRF 241
            .|.||||:||||:|||||||||.||.||.|.|||.|||||.|||||||||||:|||.||:|||||
Mouse   196 EKRKFVMKPPQVVRVGTKKTSFVNFTDICKLLHRQPKHLLAFLLAELGTSGSIDGNNQLVIKGRF 260

  Fly   242 QPKQIENVLRRYIKEYVTCHTCRSPETILQKDTRLFFLQCESCGSRCSVASIKSGFQAVTGKRAA 306
            |.|||||||||||||||||||||||:|||||||||:|||||:|.|||||||||:||||||||||.
Mouse   261 QQKQIENVLRRYIKEYVTCHTCRSPDTILQKDTRLYFLQCETCHSRCSVASIKTGFQAVTGKRAQ 325

  Fly   307 IRAK 310
            :|||
Mouse   326 LRAK 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF2beta	NP_524043.1	eIF2B_5	178..287	CDD:214764	91/108 (84%)
Eif2s2	NP_080306.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..75		22/66 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	97..120		10/27 (37%)
		eIF2B_5	197..306	CDD:214764	91/108 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850413
Domainoid	1	1.000	193	1.000	Domainoid score	I3186
eggNOG	1	0.900	-	-		E1_COG1601
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2904
Inparanoid	1	1.050	343	1.000	Inparanoid score	I2319
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55888
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004439
OrthoInspector	1	1.000	-	-		oto94310
orthoMCL	1	0.900	-	-		OOG6_101265
Panther	1	1.100	-	-	LDO	PTHR23001
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R592
SonicParanoid	1	1.000	-	-		X3723
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790