DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF2beta and Eif2s2

DIOPT Version :9

Sequence 1:	NP_524043.1	Gene:	eIF2beta / 39433	FlyBaseID:	FBgn0004926	Length:	312	Species:	Drosophila melanogaster
Sequence 2:	NP_955412.1	Gene:	Eif2s2 / 296302	RGDID:	735192	Length:	333	Species:	Rattus norvegicus

Alignment Length:	338	Identity:	197/338 - (58%)
Similarity:	230/338 - (68%)	Gaps:	48/338 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 FDPTLLKKKKKKKTTFDLDAALGLEDDTKKE------------DPQDEASAEGGAAAEEDNL--- 56
            ||||:.|||||||..|.||.    |.|.:.|            :|.:|...|   |.|||:.
  Rat     8 FDPTMSKKKKKKKKPFMLDE----EGDAQTEETQPSETKEVEPEPAEEKDVE---ADEEDSRKKD 65

  Fly    57 ------DLESFGKKKKKK--KKPFNMDEIEAAIPSFGGDDV---AASEEPEEEEINLDMDFSMAK 110
                  ||..|.:|||||  ||.|::||.|.||     .||   :.::||.|.|.:||:.....|
  Rat    66 ASDDLDDLNFFNQKKKKKKTKKIFDIDEAEEAI-----KDVKIESDAQEPAEPEDDLDIMLGNKK 125

  Fly   111 KKKKSKK-KELDELF-ADQADDDKSEDKENDE------DNSSTWFGSDRDYTYDELLKRVFEIIL 167
            ||||:.| .:.||:. .|:|.:|  ||.:.|:      .....|.||:|||||:|||.|||.|:.
  Rat   126 KKKKNVKFPDEDEILEKDEALED--EDSKKDDGISFSNQTGPAWAGSERDYTYEELLNRVFNIMR 188

  Fly   168 DKNPDMAAGRKPKFVMRPPQVLRVGTKKTSFANFMDIAKTLHRLPKHLLDFLLAELGTSGSMDGN 232
            :|||||.||.|.||||:||||:|||||||||.||.||.|.|||.|||||.|||||||||||:|||
  Rat   189 EKNPDMVAGEKRKFVMKPPQVVRVGTKKTSFVNFTDICKLLHRQPKHLLAFLLAELGTSGSIDGN 253

  Fly   233 QQLIIKGRFQPKQIENVLRRYIKEYVTCHTCRSPETILQKDTRLFFLQCESCGSRCSVASIKSGF 297
            .||:||||||.|||||||||||||||||||||||:|||||||||:|||||:|.|||||||||:||
  Rat   254 NQLVIKGRFQQKQIENVLRRYIKEYVTCHTCRSPDTILQKDTRLYFLQCETCHSRCSVASIKTGF 318

  Fly   298 QAVTGKRAAIRAK 310
            ||||||||.:|||
  Rat   319 QAVTGKRAQLRAK 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF2beta	NP_524043.1	eIF2B_5	178..287	CDD:214764	91/108 (84%)
Eif2s2	NP_955412.1	eIF2B_5	199..308	CDD:214764	91/108 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354112
Domainoid	1	1.000	193	1.000	Domainoid score	I3101
eggNOG	1	0.900	-	-		E1_COG1601
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2904
Inparanoid	1	1.050	340	1.000	Inparanoid score	I2288
OMA	1	1.010	-	-		QHG55888
OrthoDB	1	1.010	-	-		D1178655at2759
OrthoFinder	1	1.000	-	-		FOG0004439
OrthoInspector	1	1.000	-	-		oto97828
orthoMCL	1	0.900	-	-		OOG6_101265
Panther	1	1.100	-	-	LDO	PTHR23001
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3723
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770