DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF2beta and tif212

DIOPT Version :9

Sequence 1:	NP_524043.1	Gene:	eIF2beta / 39433	FlyBaseID:	FBgn0004926	Length:	312	Species:	Drosophila melanogaster
Sequence 2:	NP_593772.2	Gene:	tif212 / 2542942	PomBaseID:	SPAC32A11.04c	Length:	321	Species:	Schizosaccharomyces pombe

Alignment Length:	324	Identity:	147/324 - (45%)
Similarity:	186/324 - (57%)	Gaps:	59/324 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 KKKKKKKTTFDLDAALGLEDDTKKEDPQ-------DEASAEGGAAA----------EEDNL-DLE 59
            |||.||...||.:.     |...|:.|:       ||..:|..::|          |.|.| |:.
pombe    21 KKKPKKSVAFDDEV-----DAVSKDGPEASSAGATDEDDSERKSSAKDLTTPVTEGEVDELKDMF 80

  Fly    60 SFGKKKKKKKKPFNMDEIEAAIPSFGGDDVAASEEPEEEEINL---DMDFSMAKKKKKSKK---- 117
            |..|||||.||.                  :||.|.:.|:|..   ::|||..|||||.||
pombe    81 SSMKKKKKSKKS------------------SASAEEQTEDITTESGELDFSSMKKKKKKKKSADL 127

  Fly   118 ----KELDELFADQADDDKSE---DKENDEDNSSTWFGSDRDYTYDELLKRVFEIILDKNPDMAA 175
                |||:......|..|.|:   |.||..:::  |..|||||.|.|||.|.|.::...||:: |
pombe   128 SAFEKELEASSTGDATSDLSKQTFDSENMGEHA--WLKSDRDYYYPELLNRFFTLLRTNNPEL-A 189

  Fly   176 GRKPKFVMRPPQVLRVGTKKTSFANFMDIAKTLHRLPKHLLDFLLAELGTSGSMDGNQQLIIKGR 240
            |.|.|:.:.||.|.|.| |||.|||..||:|.:||...|::.||.||||||||:||:.:||||||
pombe   190 GEKRKYTIVPPSVHREG-KKTIFANISDISKRMHRSLDHVIQFLFAELGTSGSVDGSSRLIIKGR 253

  Fly   241 FQPKQIENVLRRYIKEYVTCHTCRSPETILQKDTRLFFLQCESCGSRCSVASIKSGFQAVTGKR 304
            ||.|||||||||||.|||||.||:||:|||.|:.|:||:.||:|||..||.:||:|:||..|||
pombe   254 FQQKQIENVLRRYIVEYVTCKTCKSPDTILTKENRIFFMTCEACGSVRSVQAIKTGYQAQIGKR 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF2beta	NP_524043.1	eIF2B_5	178..287	CDD:214764	70/108 (65%)
tif212	NP_593772.2	eIF2B_5	192..300	CDD:214764	70/108 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	146	1.000	Domainoid score	I1136
eggNOG	1	0.900	-	-		E1_COG1601
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	227	1.000	Inparanoid score	I873
OMA	1	1.010	-	-		QHG55888
OrthoFinder	1	1.000	-	-		FOG0004439
OrthoInspector	1	1.000	-	-		oto101642
orthoMCL	1	0.900	-	-		OOG6_101265
Panther	1	1.100	-	-	LDO	PTHR23001
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R592
SonicParanoid	1	1.000	-	-		X3723
TreeFam	1	0.960	-	-
	13	12.860