DRSC/TRiP Functional Genomics Resources

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Protein Alignment Gcn5 and KAT2B

DIOPT Version :9

Sequence 1:NP_648586.2 Gene:Gcn5 / 39431 FlyBaseID:FBgn0020388 Length:813 Species:Drosophila melanogaster
Sequence 2:NP_003875.3 Gene:KAT2B / 8850 HGNCID:8638 Length:832 Species:Homo sapiens


Alignment Length:829 Identity:384/829 - (46%)
Similarity:535/829 - (64%) Gaps:78/829 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 QAANGAATAGASG---------AAGSAQNPGHGGAASGAGSVPAEGTRQNSLQRIQQRKQKVFNL 84
            |.:..||.||.||         |||:|:.||.||:|                 ||..:|.::.:.
Human    38 QGSPCAAAAGGSGACGPATAVAAAGTAEGPGGGGSA-----------------RIAVKKAQLRSA 85

  Fly    85 PVPQKLAKLSMYSACQS-EGCRCTGWKTPQEN---RHRDVESSYCPEFNEECRNTSCRHSLRSHI 145
            |..:||.||.:||||:: |.|:|.|||.|..:   ...|:: .......|.||  ||.|:|.:|:
Human    86 PRAKKLEKLGVYSACKAEESCKCNGWKNPNPSPTPPRADLQ-QIIVSLTESCR--SCSHALAAHV 147

  Fly   146 AHLDNISSSSMNELLGAIIDMENLFMSMQRVEDEDTKKVYQYLFRLLRQCVLTRQQAVIRGPL-G 209
            :||:|:|...||.|||.::|:|.||..:.:.||.|||:||.|||:|||:.:|.|.:.|:.|.| .
Human   148 SHLENVSEEEMNRLLGIVLDVEYLFTCVHKEEDADTKQVYFYLFKLLRKSILQRGKPVVEGSLEK 212

  Fly   210 DPPFETPCITKAVLSLVFYKYNHLSTPELQTMTEVAKTFLNFLNHYNFESPSTRRGDLTHEDASN 274
            .||||.|.|.:.|.:.|.||::||...|.||:.|:||.|||.:|:::.|:||.||....::|.|.
Human   213 KPPFEKPSIEQGVNNFVQYKFSHLPAKERQTIVELAKMFLNRINYWHLEAPSQRRLRSPNDDISG 277

  Fly   275 YKINYTRWLVFCHVPAFCNSLRQCETSLVFGRTLLRTVFQCMSQQLKKKCISERDRFPEDKRS-I 338
            ||.||||||.:|:||.||:||.:.||:.||||||||:||..|.:||.::...|:|:.|.:||: |
Human   278 YKENYTRWLCYCNVPQFCDSLPRYETTQVFGRTLLRSVFTVMRRQLLEQARQEKDKLPLEKRTLI 342

  Fly   339 ITLMPKFLETLRAELLKDDSPIWDTSYRPSNSFVIQQRKRNQEVANVPIGPSAASIGGNK----- 398
            :|..||||..|..|:...:|||||..:..::|...|  ...|.|.|.|  |.|.:|..|.     
Human   343 LTHFPKFLSMLEEEVYSQNSPIWDQDFLSASSRTSQ--LGIQTVINPP--PVAGTISYNSTSSSL 403

  Fly   399 ------------RTSVGEPLHKRIKKEPTDRPSSEN------LDDLPADVVMRAMKSVSESKTTN 445
                        :.|.|...:...|::.||....|.      :.|:|.:::...|.::     |:
Human   404 EQPNAGSSSPACKASSGLEANPGEKRKMTDSHVLEEAKKPRVMGDIPMELINEVMSTI-----TD 463

  Fly   446 KAEILFP------VNVSRDENVKAEEQKRAIEFHVVGNSLTKPVDKQTVLWLLGLQLVFAYQLPE 504
            .|.:|.|      .:.:|||..:.||::..||||||||||.:..:|:.::||:|||.||::|||.
Human   464 PAAMLGPETNFLSAHSARDEAARLEERRGVIEFHVVGNSLNQKPNKKILMWLVGLQNVFSHQLPR 528

  Fly   505 MPREYISQLVFDTKHKTLALIKENQPIGGICFRPFPSQGFTEIVFCAVTMSEQVKGYGTHLMNHL 569
            ||:|||::||||.|||||||||:.:.|||||||.|||||||||||||||.:||||||||||||||
Human   529 MPKEYITRLVFDPKHKTLALIKDGRVIGGICFRMFPSQGFTEIVFCAVTSNEQVKGYGTHLMNHL 593

  Fly   570 KDYSIQRGIKHLLTFADCDAIGYFKKQGFSKDIKLARPVYAGYIKEYDSATLMHCELHPSIVNTQ 634
            |:|.|:..|.:.||:||..||||||||||||:||:.:..|.||||:|:.||||.|||:|.|..|:
Human   594 KEYHIKHDILNFLTYADEYAIGYFKKQGFSKEIKIPKTKYVGYIKDYEGATLMGCELNPRIPYTE 658

  Fly   635 FIAVIRSQSEILKELIAQRHNEVQKVRPGLTCFKEGLPVIPVESIPGLREIGWKPQNRPARSSRP 699
            |..:|:.|.||:|:||.::..:::||.|||:|||:|:..||:|||||:||.||||..: .:|..|
Human   659 FSVIIKKQKEIIKKLIERKQAQIRKVYPGLSCFKDGVRQIPIESIPGIRETGWKPSGK-EKSKEP 722

  Fly   700 LEESTDPEKLATSFASVLQSVRQHTTAWPFLRPVTAAEVPDYYDHIKYPMDLKTMGERLKKGYYQ 764
                .||::|.::..|:||.|:.|.:||||:.||...|.|.||:.|::|||||||.||||..||.
Human   723 ----RDPDQLYSTLKSILQQVKSHQSAWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLKNRYYV 783

  Fly   765 TRRLFMADMARIFSNCRFYNSPDTEYYRCANSLERYFQTKMRELGLWDK 813
            :::|||||:.|:|:||:.||.|::|||:|||.||::|.:|::|.||.||
Human   784 SKKLFMADLQRVFTNCKEYNPPESEYYKCANILEKFFFSKIKEAGLIDK 832

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gcn5NP_648586.2 PCAF_N 73..322 CDD:283997 118/253 (47%)
COG5076 451..807 CDD:227408 205/361 (57%)
Acetyltransf_1 526..598 CDD:278980 53/71 (75%)
Bromo_gcn5_like 708..808 CDD:99941 52/99 (53%)
KAT2BNP_003875.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..54 7/15 (47%)
PCAF_N 75..325 CDD:368925 117/252 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 395..436 6/40 (15%)
COG5076 487..826 CDD:227408 201/343 (59%)
Acetyl-CoA binding. /evidence=ECO:0000269|PubMed:10393169 574..576 1/1 (100%)
Acetyl-CoA binding. /evidence=ECO:0000269|PubMed:10393169 581..587 5/5 (100%)
Acetyl-CoA binding. /evidence=ECO:0000269|PubMed:10393169 612..615 1/2 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 706..725 8/23 (35%)
Bromo_gcn5_like 727..826 CDD:99941 52/98 (53%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 239 1.000 Domainoid score I2284
eggNOG 1 0.900 - - E1_COG5076
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 728 1.000 Inparanoid score I616
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG49011
OrthoDB 1 1.010 - - D180844at33208
OrthoFinder 1 1.000 - - FOG0002578
OrthoInspector 1 1.000 - - otm41355
orthoMCL 1 0.900 - - OOG6_101489
Panther 1 1.100 - - LDO PTHR45750
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R479
SonicParanoid 1 1.000 - - X1691
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.870

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