DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gcn5 and BRD2

DIOPT Version :9

Sequence 1:	NP_648586.2	Gene:	Gcn5 / 39431	FlyBaseID:	FBgn0020388	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	NP_001186384.1	Gene:	BRD2 / 6046	HGNCID:	1103	Length:	836	Species:	Homo sapiens

Alignment Length:	504	Identity:	107/504 - (21%)
Similarity:	174/504 - (34%)	Gaps:	154/504 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   387 IGPSAASIGGNKRTSVGEPLHKRIKK-----EPTDRPSSENLDDLPADVVMRAMKSVSESK---- 442
            :||.||:.|            |||:|     |..:.|:..::..|...........||..|
Human    22 LGPEAAAPG------------KRIRKPSLLYEGFESPTMASVPALQLTPANPPPPEVSNPKKPGR 74

  Fly   443 TTNKAEILFPVNVSRDENVKAEEQKRAIEFHVVGNSLTKPVDKQTVLWLLGLQLVFAYQLPEMPR 507
            .||:.:.|..|.:            :|:..|.......:|||...    |||.
Human    75 VTNQLQYLHKVVM------------KALWKHQFAWPFRQPVDAVK----LGLP------------ 111

  Fly   508 EYISQLVFDTKHKTLALIKENQPIGGI--------------CFRPFPSQGFT----------EIV 548
            :|         ||   :||:...:|.|              |.:.|.:. ||          :||
Human   112 DY---------HK---IIKQPMDMGTIKRRLENNYYWAASECMQDFNTM-FTNCYIYNKPTDDIV 163

  Fly   549 FCAVTMSEQVKGYGTHLMNHLKDYSIQRGIKHLLTFADCDAIGYFKKQGFSKDIKLARPVYAGYI 613
            ..|.|               |:...:|:...  :...:.:.:....|....|..|||  ...|.:
Human   164 LMAQT---------------LEKIFLQKVAS--MPQEEQELVVTIPKNSHKKGAKLA--ALQGSV 209

  Fly   614 KEYDS----ATLMHCEL---------------HPSIVNTQFIAVIRSQSEILKELIAQRHNEVQK 659
            .....    :::.|..|               |||::::..:..:.|....|..:.|....:...
Human   210 TSAHQVPAVSSVSHTALYTPPPEIPTTVLNIPHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLA 274

  Fly   660 VRPGL------------TCFKEGLPVIPVESI--------PGLREIG--WKPQNRPARSSRPLEE 702
            .:.|:            .....|.|..|..|:        |..||.|  .||..:....|:...:
Human   275 KKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQ 339

  Fly   703 STDPEKLA------TSFASVLQSVRQHTTAWPFLRPVTAAE--VPDYYDHIKYPMDLKTMGERLK 759
            |:...||:      ......|.|.:....||||.:||.|:.  :.||:|.||:||||.|:..:::
Human   340 SSKKGKLSEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKME 404

  Fly   760 KGYYQTRRLFMADMARIFSNCRFYNSPDTEYYRCANSLERYFQTKMREL 808
            ...|:..:.|.||:..:||||..||.||.:....|..|:..|:.:..::
Human   405 NRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKM 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gcn5	NP_648586.2	PCAF_N	73..322	CDD:283997
		COG5076	451..807	CDD:227408	89/428 (21%)
		Acetyltransf_1	526..598	CDD:278980	14/95 (15%)
		Bromo_gcn5_like	708..808	CDD:99941	36/107 (34%)
BRD2	NP_001186384.1	Bromo_Brdt_I_like	74..180	CDD:99929	29/163 (18%)
		Bromo_Brdt_II_like	349..450	CDD:99930	34/100 (34%)
		GVQW	616..>651	CDD:290611
		BET	676..740	CDD:293640
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910