Protein Alignment Gcn5 and ep300b

DIOPT Version :9

• Sequence 1: NP_648586.2
• Gene: Gcn5 / 39431
• FlyBaseID: FBgn0020388
• Length: 813
• Species: Drosophila melanogaster
• Sequence 2: XP_009297682.1
• Gene: ep300b / 565612
• ZFINID: ZDB-GENE-080403-15
• Length: 2646
• Species: Danio rerio
• Alignment Length: 1072
• Identity: 185/1072 - (17%)
• Similarity: 320/1072 - (29%)
• Gaps: 379/1072 - (35%)

  Fly     1 MSGGPSITIKS--QPIDGNNTGNAAAQQQQQ-AANGAATAGASGAAGSA---------------- 46
            |:|..::...|  ||..|.....||.:.||. |.|.....||.|..|.:
Zfish   190 MAGNGNMLPDSLQQPNAGQQMAQAAMRPQQPGAVNKMGMMGAPGPYGGSYGQCGGQSQLGPQLQN 254

  Fly    47 --------------------------QNPGHGGAASGAGSVPAEGTRQNSLQRIQQRKQKVFNLP 85
                                      |.||..|..||.|...|.       ......|:|:
Zfish   255 KAGQPNSINQFNMDKKPQLGQNMGGMQGPGVVGGVSGPGGTAAP-------PAADPEKRKL---- 308

  Fly    86 VPQKLAKLSMYSAC----QSEG----CRCTGWKTPQENRHRDVESSYCPEFNEECRNTSCRHSLR 142
            :.|:|..|.....|    |:.|    |.....:|.:...:   ..::| :..:.|:...|..| |
Zfish   309 IQQQLVLLLHAHKCHRREQANGEVRQCNLPHCRTMKNVLN---HMTHC-QAGKSCQVAHCASS-R 368

  Fly   143 SHIAHLDNISSSSMNELLGAIIDMENLFMSMQRVEDEDTKKVYQYLFRLLRQCVLTRQQAVIRGP 207
            ..|:|..|.:....           .:.:.::...|:..           :|.:|......:.||
Zfish   369 QIISHWKNCTRHDC-----------PVCLPLKSAGDKRN-----------QQSLLGGAGMAMGGP 411

  Fly   208 LG-------------DPP--FETPCITKAVLSL-VFYKYNHLSTPELQTMTEVAKTFLNFLN--- 253
            ||             :||  .:...|.:|..:| :.|:.|..|....||... .:..:..||
Zfish   412 LGGSLPGGQPSAPNINPPSQIDPSSIERAYAALGLTYQGNQASNQNQQTSVP-GQPGMRSLNNMA 475

  Fly   254 ----------------------------HYNFES---------------------PSTRRGDLTH 269
                                        |.|..:                     ||.......|
Zfish   476 GGNSMGVNGGVGAPMSNQHPGMLPDGMLHRNMTAQSLMNDSSGVGNMGSAATATPPSAGMRKSWH 540

  Fly   270 EDAS----NYKINYTRWLVFCHVPAFCNSLRQCETSLVFGRTLLRTVFQCMSQQLK-KKCISERD 329
            ||.:    |:.::.....:|..........|:.|..:.:.|.:...:::..:.:.: ...::|:
Zfish   541 EDITQDLRNHLVHKLVQAIFPTPDPAALKDRRMENLVAYARKVEGDMYESANSRAEYYHLLAEK- 604

  Fly   330 RFPEDKRSIITLMPKFLETLRAELLKDDSPIWDTSYRPSNSFVIQQRKRNQEVANV--PIGPSAA 392
                    |..:..:..|..|..|.|.|.|..|.|       ::|....:|.|..:  |.|...:
Zfish   605 --------IYKIQKELEEKRRTRLQKQDGPHSDPS-------LVQATGPSQMVNRMQNPAGMPHS 654

  Fly   393 SIGGNKRTSVG--EPLHKR-------------IKKEPTDRPSSENLDDLPADVV----------- 431
            ..|.|:...||  :|:.:|             :..:.|.|.:..|:..|....:
Zfish   655 LNGMNQFGQVGMQQPMGQRATPPLPMGANLNQMSMQGTPRMAQPNVPQLQNQYMQNQFTGTGAGL 719

  Fly   432 --------------------MRAMKSVSESKTTNKAEILFPVNVSR------DENVKAEEQKRAI 470
                                |....|:|......:::...||:.:.      ..|......:..:
Zfish   720 GQGAVGLNQPAGQGAMPQNQMPTPPSLSVHSPVAQSQSSVPVSGAAAGPQGPPSNHPPPAPQPGL 784

  Fly   471 EFHV---------VGNSLT-KPVDKQTVLWLLGLQLVF-------------AYQLPEMPREYISQ 512
            ..|.         ...||| .|...||...|.|.|...             |.|||.|     :|
Zfish   785 HTHCPPLRQNSPSPARSLTPTPAPHQTPPQLPGNQTPQPHTPNSSTTMAPPASQLPPM-----AQ 844

  Fly   513 LVFDTKHKTLALIKENQPIGGICFRPFPSQGFTEIVFCAVTMSEQVKGYGTHLMNHLKDYSIQRG 577
            .|...|...|    :.|..||      .:.|..:....:...|:...|..||..:.|.
Zfish   845 GVASEKSSQL----QQQSHGG------GATGGPQTGLASSVPSQNAHGLCTHPHSPLS------- 892

  Fly   578 IKHLLTFADCDAIGYFKKQGFSKDIKLARPVYAGYIKEYDSATLMHCELHPSIVNTQFIAVIRSQ 642
                            :|...:.|.:.:.|           |::...:....:.:::..|.:.|:
Zfish   893 ----------------QKSSATVDGQASTP-----------ASVSSADPSSQLTSSEPTAPLDSK 930

  Fly   643 SEILK------------------------ELIAQRHNEVQKVRP-GLTCFKEGLPVIPVESIPGL 682
            :|:.:                        |:.::...|::|..| |..|..|.:.....|
Zfish   931 TEVKQQDEEEENENETEDKASGKMAAMQTEIKSEEKPEIKKEEPAGDECKTEPMETSTAE----- 990

  Fly   683 REIGWKPQNRPARSSRPLEEST-----------------DPEKLATSFASVLQSV-RQHTTAWPF 729
                   ..:|...:.|.||..                 .|::|..:....|::: ||...:.||
Zfish   991 -------DKKPEVKTEPKEEEVAGANSTPANTQSKKKEFKPDELRQALMPTLEALYRQDPESLPF 1048

  Fly   730 LRPV--TAAEVP-----------DYYDHIKYPMDLKTMGERLKKGYYQTRRLFMADMARIFSNCR 781
            .:||  ....:|           ||:|.:|.|:||.|:..:|..|.||....::.|:..:|:|..
Zfish  1049 RQPVDPQLLGIPVRIRTSNKTNLDYFDIVKNPIDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAW 1113

  Fly   782 FYNSPDTEYYRCANSLERYFQTK----MRELG 809
            .||...:..|:..:.|...|:.:    |:|||
Zfish  1114 LYNRKTSRVYKYCSKLAEVFEQEIDPVMQELG 1145

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gcn5	NP_648586.2	PCAF_N	73..322	CDD:283997	49/329 (15%)
		COG5076	451..807	CDD:227408	81/444 (18%)
		Acetyltransf_1	526..598	CDD:278980	10/71 (14%)
		Bromo_gcn5_like	708..808	CDD:99941	30/117 (26%)
ep300b	XP_009297682.1	zf-TAZ	318..385	CDD:280324	13/82 (16%)
		KIX	534..614	CDD:280354	10/88 (11%)
		Bromo_cbp_like	1024..1142	CDD:99927	30/117 (26%)
		RING_CBP-p300	1154..1236	CDD:276805
		PHD_SF	1237..1271	CDD:304600
		HAT_KAT11	1300..1607	CDD:285432
		ZZ_CBP	1663..1703	CDD:239077
		ZnF_TAZ	1724..1802	CDD:214717
		Creb_binding	<2164..2231	CDD:286163

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900