DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Gcn5 and Lpt

DIOPT Version :9

Sequence 1:NP_648586.2 Gene:Gcn5 / 39431 FlyBaseID:FBgn0020388 Length:813 Species:Drosophila melanogaster
Sequence 2:NP_611847.2 Gene:Lpt / 37795 FlyBaseID:FBgn0263667 Length:1482 Species:Drosophila melanogaster


Alignment Length:499 Identity:96/499 - (19%)
Similarity:163/499 - (32%) Gaps:132/499 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   307 TLLRTVFQCMSQQLKKKCISERDRFPEDKRSIITLMPKFLETL--------RAELL---KDDSPI 360
            |.:..:...|:...|||.|.::     .|..:|...|.:|:..        ..||:   .|.|..
  Fly   886 TAVDQINSLMTMDKKKKIIRKK-----QKNKLIEAYPVYLQEAFFGKPLLEGGELVMADTDSSDE 945

  Fly   361 WDTSYR----------PSNSFVIQQRK---------------RNQEV--ANVPIGPSAASIGGNK 398
            .|.|.:          |:|...:...|               .|:.|  ..:|:|....: |...
  Fly   946 IDASMKVYFTRPEGKSPANQDTLAVNKSPAKTVKKVKAELKTENKTVFIQQMPMGIQNKN-GTTP 1009

  Fly   399 RTSVGEPLHKRI------KKEPTDRPSSENLDDL----------PADVVMRAMKSVSESKTTNKA 447
            .::|.:||...|      .:.|.|..:|.|:.:|          .|:|:.:.|:   ||......
  Fly  1010 VSNVFDPLQAEISNTVFANRHPLDALASPNVPELDMANSVSTVPSAEVIEKPMR---ESPAVLVD 1071

  Fly   448 EILFPVNVSRDENVKAEEQKRAIEFHVVGNSLTKPVDKQTVLWLLGLQLVFAYQLPEMPRE---- 508
            ..:.|       |...:|||...:.::.||:|..|..          ||.|..|.|:...:    
  Fly  1072 SFMVP-------NQLPQEQKFHNQLYLGGNTLVNPAQ----------QLQFRQQAPQNANKQNMQ 1119

  Fly   509 -YISQLVFDTKHKTLALIKENQPIGGICFRPFPSQGFTEIVFCAVTMSEQVKGYGTHLMNHLKDY 572
             .:||:|..|:.                 ||...|...|.|       .:....||.     |..
  Fly  1120 TIMSQVVLQTEK-----------------RPEEEQKVVEPV-------TETLNAGTQ-----KTA 1155

  Fly   573 SIQRGIKHLLTFADCDAIGYFKKQGFSKDIKLARPVYAGYIKEYDSATLMHCE------LHPSIV 631
            ...|..:.|...|...|:.|...:  ..::|...|::....|:........|.      |..:..
  Fly  1156 EKMRKDEDLGLMATISAVLYANTE--HPNLKELFPIWNDRCKQILKRWRSLCNEKKAPFLQKAKD 1218

  Fly   632 NTQFIAVIRSQSEILKELIAQRHNEVQKVRPGLTCFKEGLPVIPVESIPGLREIGWKPQNRPARS 696
            |...:...|.|::|......|:..|:.:|.......||..|.:.|.......::|    |....|
  Fly  1219 NRSALRQRREQNKIPMPPKPQKQEEMGRVWKQPPKLKEDQPNMFVTYNGNAYDMG----NYVGGS 1279

  Fly   697 SRPLEESTDPEKLATS------FASVLQSVRQHTTAWPFLRPVT 734
            ::....:.:|..:..:      ..:.:|..:.||||...|:..|
  Fly  1280 AQAASNNPNPHHVMPNVNDNLVIKATMQRTQVHTTAASTLKMTT 1323

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gcn5NP_648586.2 PCAF_N 73..322 CDD:283997 2/14 (14%)
COG5076 451..807 CDD:227408 58/301 (19%)
Acetyltransf_1 526..598 CDD:278980 13/71 (18%)
Bromo_gcn5_like 708..808 CDD:99941 7/33 (21%)
LptNP_611847.2 ePHD1_KMT2C_like 109..191 CDD:277135
PHD1_KMT2C_like 205..250 CDD:276984
PHD2_KMT2C_like 252..298 CDD:276985
PHD_SF 337..392 CDD:304600
PHD4_KMT2C_like 530..578 CDD:276987
PHD5_KMT2C_like 580..625 CDD:276988
PHD6_KMT2C_like 657..707 CDD:276989
NHP6B 1101..>1237 CDD:227935 31/176 (18%)
HMG 1173..1231 CDD:197700 9/59 (15%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5076
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.900

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