DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gcn5 and Kat2a

DIOPT Version :9

Sequence 1:	NP_648586.2	Gene:	Gcn5 / 39431	FlyBaseID:	FBgn0020388	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	XP_006247379.1	Gene:	Kat2a / 303539	RGDID:	1307242	Length:	833	Species:	Rattus norvegicus

Alignment Length:	847	Identity:	386/847 - (45%)
Similarity:	542/847 - (63%)	Gaps:	59/847 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 SQPIDGNNTGNAAAQQQQQAANGAATAGASGAAGSAQNP------------------GHGGAASG 57
            ::|....|...||..:..|:...|.|:..:.:..||..|                  |.|||..|
  Rat     2 AEPSQAPNPAPAAQPRPLQSPAPAPTSTPAPSPASAPTPAPTPAPAPAPAAAPAGSTGTGGAGVG 66

  Fly    58 AGSVPAE-GTRQNSLQRIQQRKQKVFNLPVPQKLAKLSMYSACQ-SEGCRCTGWKTPQENR--HR 118
            :|..||. |..|.  ||..|||.:|..||..:||.||.::|||: :|.|:|.|||.|:...  ..
  Rat    67 SGGDPARPGLSQQ--QRASQRKAQVRGLPRAKKLEKLGVFSACKANETCKCNGWKNPKPPTAPRM 129

  Fly   119 DVESSYCPEFNEECRNTSCRHSLRSHIAHLDNISSSSMNELLGAIIDMENLFMSMQRVEDEDTKK 183
            |::.. ....:|.||  ||.|.|..|::||:|:|...:|.|||.::|:||||||:.:.||.|||:
  Rat   130 DLQQP-AANLSELCR--SCEHPLADHVSHLENVSEDEINRLLGMVVDVENLFMSVHKEEDTDTKQ 191

  Fly   184 VYQYLFRLLRQCVLTRQQAVIRGPLGDPPFETPCITKAVLSLVFYKYNHLSTPELQTMTEVAKTF 248
            ||.|||:|||:|:|...:.|:.|.||.||||.|.|.:.||:.|.||::||:..|.|||.|::|.|
  Rat   192 VYFYLFKLLRKCILQMTRPVVEGSLGSPPFEKPNIEQGVLNFVQYKFSHLAPRERQTMFELSKMF 256

  Fly   249 LNFLNHYNFESPSTRRGDLTHEDASNYKINYTRWLVFCHVPAFCNSLRQCETSLVFGRTLLRTVF 313
            |..||::..|:|:..|.....||.:.||:||||||.:||||..|:||.:.||:.||||:|||::|
  Rat   257 LLCLNYWKLETPAQFRQRSQSEDVATYKVNYTRWLCYCHVPQSCDSLPRYETTHVFGRSLLRSIF 321

  Fly   314 QCMSQQLKKKCISERDRF-PEDKRSIITLMPKFLETLRAELLKDDSPIWDTSYR--PSNSFVIQQ 375
            ....:||.:|...|:|:. ||.:..|:|..||||..|..|:...:||||::.:.  ||....:..
  Rat   322 TVTRRQLLEKFRVEKDKLVPEKRTLILTHFPKFLSMLEEEIYGANSPIWESGFTMPPSEGTQLVP 386

  Fly   376 RKRNQEVANVPIGP-SAASIGGNKRTSVG------EPLHKRIKKEPTDRPSSEN------LDDLP 427
            |........||..| .:.|:||...:|:.      ||:....|::..:..:.|:      :.|:|
  Rat   387 RPATVSATVVPSTPIFSPSMGGGSNSSLSLDSTGTEPMPAGEKRKLPENLTLEDAKRLRVMGDIP 451

  Fly   428 ADVVMRAMKSVSESKTTNKAEILFP------VNVSRDENVKAEEQKRAIEFHVVGNSLTKPVDKQ 486
            .::|...|.::     |:.|.:|.|      .|.:|||..:.||::..|||||:|||||...:::
  Rat   452 MELVNEVMLTI-----TDPAAMLGPETSLLSANAARDETARLEERRGIIEFHVIGNSLTPKANRR 511

  Fly   487 TVLWLLGLQLVFAYQLPEMPREYISQLVFDTKHKTLALIKENQPIGGICFRPFPSQGFTEIVFCA 551
            .:|||:|||.||::|||.||:|||::||||.|||||||||:.:.|||||||.||:||||||||||
  Rat   512 VLLWLVGLQNVFSHQLPRMPKEYIARLVFDPKHKTLALIKDGRVIGGICFRMFPTQGFTEIVFCA 576

  Fly   552 VTMSEQVKGYGTHLMNHLKDYSIQRGIKHLLTFADCDAIGYFKKQGFSKDIKLARPVYAGYIKEY 616
            ||.:|||||||||||||||:|.|:..|.:.||:||..|||||||||||||||:.:..|.||||:|
  Rat   577 VTSNEQVKGYGTHLMNHLKEYHIKHSILYFLTYADEYAIGYFKKQGFSKDIKVPKSRYLGYIKDY 641

  Fly   617 DSATLMHCELHPSIVNTQFIAVIRSQSEILKELIAQRHNEVQKVRPGLTCFKEGLPVIPVESIPG 681
            :.||||.|||:|.|..|:...:|:.|.||:|:||.::..:::||.|||:|||||:..|||||:||
  Rat   642 EGATLMECELNPRIPYTELSHIIKKQKEIIKKLIERKQAQIRKVYPGLSCFKEGVRQIPVESVPG 706

  Fly   682 LREIGWKPQNRPARSSRPLEESTDPEKLATSFASVLQSVRQHTTAWPFLRPVTAAEVPDYYDHIK 746
            :||.||||..:...     :|..||::|.|:..::|..::.|.:||||:.||..:|.||||:.|:
  Rat   707 IRETGWKPLGKEKG-----KELKDPDQLYTTLKNLLAQIKSHPSAWPFMEPVKKSEAPDYYEVIR 766

  Fly   747 YPMDLKTMGERLKKGYYQTRRLFMADMARIFSNCRFYNSPDTEYYRCANSLERYFQTKMRELGLW 811
            :|:|||||.|||:..||.||:||:||:.|:.:|||.||.||:||.|||::||::|..|::|.||.
  Rat   767 FPIDLKTMTERLRSRYYVTRKLFVADLQRVIANCREYNPPDSEYCRCASALEKFFYFKLKEGGLI 831

  Fly   812 DK 813
            ||
  Rat   832 DK 833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gcn5	NP_648586.2	PCAF_N	73..322	CDD:283997	119/251 (47%)
		COG5076	451..807	CDD:227408	203/361 (56%)
		Acetyltransf_1	526..598	CDD:278980	52/71 (73%)
		Bromo_gcn5_like	708..808	CDD:99941	50/99 (51%)
Kat2a	XP_006247379.1	PCAF_N	81..330	CDD:283997	119/251 (47%)
		COG5076	488..828	CDD:227408	198/344 (58%)
		Acetyltransf_1	551..623	CDD:278980	52/71 (73%)
		Bromo_gcn5_like	728..827	CDD:99941	50/98 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	240	1.000	Domainoid score	I2189
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41343
Inparanoid	1	1.050	725	1.000	Inparanoid score	I592
OMA	1	1.010	-	-		QHG49011
OrthoDB	1	1.010	-	-		D180844at33208
OrthoFinder	1	1.000	-	-		FOG0002578
OrthoInspector	1	1.000	-	-		oto97144
orthoMCL	1	0.900	-	-		OOG6_101489
Panther	1	1.100	-	-	O	PTHR45750
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1691
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840