DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gcn5 and KAT2A

DIOPT Version :9

Sequence 1:	NP_648586.2	Gene:	Gcn5 / 39431	FlyBaseID:	FBgn0020388	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	NP_001363156.1	Gene:	KAT2A / 2648	HGNCID:	4201	Length:	838	Species:	Homo sapiens

Alignment Length:	809	Identity:	385/809 - (47%)
Similarity:	534/809 - (66%)	Gaps:	45/809 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 ANGAATAGASGAAGSAQNPGHGGAASGAGSVPAE-GTRQNSLQRIQQRKQKVFNLPVPQKLAKLS 94
            |..||.||::|..|    ||.|...:|:|..||. |..|.  ||..|||.:|..||..:||.||.
Human    49 APAAAPAGSTGTGG----PGVGSGGAGSGGDPARPGLSQQ--QRASQRKAQVRGLPRAKKLEKLG 107

  Fly    95 MYSACQ-SEGCRCTGWKTPQENR--HRDVESSYCPEFNEECRNTSCRHSLRSHIAHLDNISSSSM 156
            ::|||: :|.|:|.|||.|:...  ..|::.. ....:|.||  ||.|.|..|::||:|:|...:
Human   108 VFSACKANETCKCNGWKNPKPPTAPRMDLQQP-AANLSELCR--SCEHPLADHVSHLENVSEDEI 169

  Fly   157 NELLGAIIDMENLFMSMQRVEDEDTKKVYQYLFRLLRQCVLTRQQAVIRGPLGDPPFETPCITKA 221
            |.|||.::|:||||||:.:.||.|||:||.|||:|||:|:|...:.|:.|.||.||||.|.|.:.
Human   170 NRLLGMVVDVENLFMSVHKEEDTDTKQVYFYLFKLLRKCILQMTRPVVEGSLGSPPFEKPNIEQG 234

  Fly   222 VLSLVFYKYNHLSTPELQTMTEVAKTFLNFLNHYNFESPSTRRGDLTHEDASNYKINYTRWLVFC 286
            ||:.|.||::||:..|.|||.|::|.||..||::..|:|:..|.....||.:.||:||||||.:|
Human   235 VLNFVQYKFSHLAPRERQTMFELSKMFLLCLNYWKLETPAQFRQRSQAEDVATYKVNYTRWLCYC 299

  Fly   287 HVPAFCNSLRQCETSLVFGRTLLRTVFQCMSQQLKKKCISERDRF-PEDKRSIITLMPKFLETLR 350
            |||..|:||.:.||:.||||:|||::|....:||.:|...|:|:. ||.:..|:|..||||..|.
Human   300 HVPQSCDSLPRYETTHVFGRSLLRSIFTVTRRQLLEKFRVEKDKLVPEKRTLILTHFPKFLSMLE 364

  Fly   351 AELLKDDSPIWDTSYR--PSNSFVIQQRKRNQEVANVPIGP-SAASIGGNKRTSV------GEPL 406
            .|:...:||||::.:.  ||....:..|..:...|.||..| .:.|:||...:|:      .||:
Human   365 EEIYGANSPIWESGFTMPPSEGTQLVPRPASVSAAVVPSTPIFSPSMGGGSNSSLSLDSAGAEPM 429

  Fly   407 --HKRIKKEPTDRPSSENL---DDLPADVVMRAMKSVSESKTTNKAEILFP------VNVSRDEN 460
              .||...|......::.|   .|:|.::|...|.::     |:.|.:|.|      .|.:|||.
Human   430 PGEKRTLPENLTLEDAKRLRVMGDIPMELVNEVMLTI-----TDPAAMLGPETSLLSANAARDET 489

  Fly   461 VKAEEQKRAIEFHVVGNSLTKPVDKQTVLWLLGLQLVFAYQLPEMPREYISQLVFDTKHKTLALI 525
            .:.||::..|||||:|||||...:::.:|||:|||.||::|||.||:|||::||||.||||||||
Human   490 ARLEERRGIIEFHVIGNSLTPKANRRVLLWLVGLQNVFSHQLPRMPKEYIARLVFDPKHKTLALI 554

  Fly   526 KENQPIGGICFRPFPSQGFTEIVFCAVTMSEQVKGYGTHLMNHLKDYSIQRGIKHLLTFADCDAI 590
            |:.:.|||||||.||:||||||||||||.:|||||||||||||||:|.|:..|.:.||:||..||
Human   555 KDGRVIGGICFRMFPTQGFTEIVFCAVTSNEQVKGYGTHLMNHLKEYHIKHNILYFLTYADEYAI 619

  Fly   591 GYFKKQGFSKDIKLARPVYAGYIKEYDSATLMHCELHPSIVNTQFIAVIRSQSE-ILKELIAQRH 654
            |||||||||||||:.:..|.||||:|:.||||.|||:|.|..|:...:|:.|.| |:|:||.::.
Human   620 GYFKKQGFSKDIKVPKSRYLGYIKDYEGATLMECELNPRIPYTELSHIIKKQKEVIIKKLIERKQ 684

  Fly   655 NEVQKVRPGLTCFKEGLPVIPVESIPGLREIGWKPQNRPARSSRPLEESTDPEKLATSFASVLQS 719
            .:::||.|||:|||||:..|||||:||:||.||||..:...     :|..||::|.|:..::|..
Human   685 AQIRKVYPGLSCFKEGVRQIPVESVPGIRETGWKPLGKEKG-----KELKDPDQLYTTLKNLLAQ 744

  Fly   720 VRQHTTAWPFLRPVTAAEVPDYYDHIKYPMDLKTMGERLKKGYYQTRRLFMADMARIFSNCRFYN 784
            ::.|.:||||:.||..:|.||||:.|::|:|||||.|||:..||.||:||:||:.|:.:|||.||
Human   745 IKSHPSAWPFMEPVKKSEAPDYYEVIRFPIDLKTMTERLRSRYYVTRKLFVADLQRVIANCREYN 809

  Fly   785 SPDTEYYRCANSLERYFQTKMRELGLWDK 813
            .||:||.|||::||::|..|::|.||.||
Human   810 PPDSEYCRCASALEKFFYFKLKEGGLIDK 838

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gcn5	NP_648586.2	PCAF_N	73..322	CDD:283997	119/251 (47%)
		COG5076	451..807	CDD:227408	203/362 (56%)
		Acetyltransf_1	526..598	CDD:278980	52/71 (73%)
		Bromo_gcn5_like	708..808	CDD:99941	50/99 (51%)
KAT2A	NP_001363156.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..99		23/55 (42%)
		PCAF_N	89..335	CDD:368925	118/248 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	407..434		6/26 (23%)
		COG5076	492..833	CDD:227408	198/345 (57%)
		Acetyl-CoA and acyl-CoA binding. /evidence=ECO:0000269\|PubMed:17410582, ECO:0000269\|PubMed:29211711, ECO:0007744\|PDB:5TRL	579..581		1/1 (100%)
		Acetyl-CoA and acyl-CoA binding. /evidence=ECO:0000269\|PubMed:17410582, ECO:0000269\|PubMed:29211711, ECO:0007744\|PDB:5TRL	586..592		5/5 (100%)
		Acetyl-CoA and acyl-CoA binding. /evidence=ECO:0000269\|PubMed:17410582, ECO:0000269\|PubMed:29211711, ECO:0007744\|PDB:5TRL	617..620		1/2 (50%)
		Loop 3. /evidence=ECO:0000269\|PubMed:29211711	639..648		5/8 (63%)
		Bromo_gcn5_like	733..832	CDD:99941	50/98 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	239	1.000	Domainoid score	I2284
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41343
Inparanoid	1	1.050	728	1.000	Inparanoid score	I616
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49011
OrthoDB	1	1.010	-	-		D180844at33208
OrthoFinder	1	1.000	-	-		FOG0002578
OrthoInspector	1	1.000	-	-		otm41355
orthoMCL	1	0.900	-	-		OOG6_101489
Panther	1	1.100	-	-	O	PTHR45750
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R479
SonicParanoid	1	1.000	-	-		X1691
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.870