DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gcn5 and gcn5

DIOPT Version :9

Sequence 1:	NP_648586.2	Gene:	Gcn5 / 39431	FlyBaseID:	FBgn0020388	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	NP_594807.1	Gene:	gcn5 / 2542513	PomBaseID:	SPAC1952.05	Length:	454	Species:	Schizosaccharomyces pombe

Alignment Length:	483	Identity:	173/483 - (35%)
Similarity:	258/483 - (53%)	Gaps:	81/483 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   357 DSPIWDTSY----RPSNSFVIQQRKRNQEVANVPIGPSAASIGGNKRTSVGEPLHKRIKKEPTDR 417
            ||.:.|::.    ..||..|..:..:..|.:|..:..:.|:..|.:..:|         ||..|.
pombe    13 DSSVVDSTSSNFPNASNDSVHDKPVKQDEQSNPNVREAIANSDGQESLAV---------KENKDT 68

  Fly   418 PSSEN----------------LDDLPADVVMRAMKSVSESKTTNKAEILFPVNVSRDENVKAEEQ 466
            .||.:                ..||..|.      .:|..:.|.|..:|             ||:
pombe    69 ESSSSHFVPNGVSNSKKRKLVATDLDVDF------DISSVRVTEKPSVL-------------EEK 114

  Fly   467 KRAIEFHVVGNSLTKPVDKQTVLWLLGLQLVFAYQLPEMPREYISQLVFDTKHKTLALIKEN-QP 530
            ...|:|.||.|..|    ..:::.|.||:.:|..|||:||:|||::|::|..|.::.::|:| ..
pombe   115 SGVIQFRVVSNDDT----ADSMIMLTGLKNIFMKQLPKMPKEYITRLIYDRNHLSMTIVKDNLHV 175

  Fly   531 IGGICFRPFPSQGFTEIVFCAVTMSEQVKGYGTHLMNHLKDYSIQRG---IKHLLTFADCDAIGY 592
            :|||.:|||..:||.||||||:..:|||:|||:|||||||||  .||   |:|.||:||..||||
pombe   176 VGGITYRPFEQRGFAEIVFCAIASNEQVRGYGSHLMNHLKDY--VRGTTTIQHFLTYADNYAIGY 238

  Fly   593 FKKQGFSKDIKLARPVYAGYIKEYDSATLMHCELHPSIVNTQFIAVIRSQSEILKELIAQRHNEV 657
            ||||||:|:|.|.:.::.||||:|:..|||.|.:.|.|...:...::..|    |..:..:.|.:
pombe   239 FKKQGFTKEITLDKSIWVGYIKDYEGGTLMQCTMIPKIKYLEANLILAIQ----KAAVVSKINRI 299

  Fly   658 QK---VRPGLTCFKEGLPVIPVESIPGLREIGW-KPQNRPARSSRPLEESTDPEKLATSFASVLQ 718
            .:   |.|||..||:|...|....:|||.|:|| |.....::..||           ..|.:||:
pombe   300 TRSNVVYPGLDVFKDGPAHIEPSQVPGLMEVGWCKEMEELSKKPRP-----------KPFFAVLE 353

  Fly   719 ----SVRQHTTAWPFLRPVTAAEVPDYYDHIKYPMDLKTMGERLKKGYYQTRRLFMADMARIFSN 779
                .::.|.::|||::||:..:|||||:.|::||||.||..||:...|::...|:.|...||.|
pombe   354 MLFTEMQNHPSSWPFMQPVSKEDVPDYYEVIEHPMDLSTMEFRLRNNQYESVEEFIRDAKYIFDN 418

  Fly   780 CRFYNSPDTEYYRCANSLERYFQTKMRE 807
            ||.||..:|.||:.|:.||::||.|:||
pombe   419 CRSYNDSNTTYYKNADRLEKFFQKKLRE 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gcn5	NP_648586.2	PCAF_N	73..322	CDD:283997
		COG5076	451..807	CDD:227408	148/367 (40%)
		Acetyltransf_1	526..598	CDD:278980	47/75 (63%)
		Bromo_gcn5_like	708..808	CDD:99941	44/104 (42%)
gcn5	NP_594807.1	COG5076	95..454	CDD:227408	155/392 (40%)
		Acetyltransf_1	170..245	CDD:278980	48/76 (63%)
		Bromo_gcn5_like	347..446	CDD:99941	42/98 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	106	1.000	Domainoid score	I1688
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002578
OrthoInspector	1	1.000	-	-		oto101278
orthoMCL	1	0.900	-	-		OOG6_101489
Panther	1	1.100	-	-	LDO	PTHR45750
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R479
SonicParanoid	1	1.000	-	-		X1691
TreeFam	1	0.960	-	-
	11	10.800