DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gcn5 and Bptf

DIOPT Version :9

Sequence 1:	NP_648586.2	Gene:	Gcn5 / 39431	FlyBaseID:	FBgn0020388	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	XP_006532738.1	Gene:	Bptf / 207165	MGIID:	2444008	Length:	3158	Species:	Mus musculus

Alignment Length:	840	Identity:	165/840 - (19%)
Similarity:	292/840 - (34%)	Gaps:	295/840 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 TIKSQPI--------DGNNTGNAAAQQQQQAANGAATAGASGAAGSAQNPGHGGAASGAGSVPAE 64
            |..||||        ...:.|...:|.|.|::....::|.:....:..:|          |.|
Mouse  2556 TTASQPIPIPPPTSLQAPSQGQPQSQPQVQSSTQTLSSGQTLNQVTVLSP----------SCP-- 2608

  Fly    65 GTRQNSLQRIQQRKQKVFNLPVPQKLAKLSMYSACQSEGCRCTGWKTPQENRHRDVESSYCPEFN 129
                       |.:.:|..:|..|::..||                        .::|....:..
Mouse  2609 -----------QPQPQVIAVPQLQQVQVLS------------------------QIQSQVVAQIQ 2638

  Fly   130 EECRNTSCRHSLRSHIAHLDNISSSSMNELLGAIIDMENLFMSMQRVEDEDTKKVYQYLFRLLRQ 194
            .:......:..|:..|....|.::.:.:.:......::.....:|::.|:..||         :|
Mouse  2639 AQQSGVPQQIKLQLPIQVQQNSAAQTQSVVTVQAASVQEQLQRVQQLRDQQQKK---------KQ 2694

  Fly   195 CVLTRQQAVIRGPLGDPPFETPCITKAVLSLVFYKYN----HLSTPELQTMTEVAKTFLNFLNHY 255
            .:.|.::..::.     ..::..|.|.|:    .|:|    ||.  :.:|||
Mouse  2695 QIETEREHTLQA-----SNQSEIIQKQVV----MKHNAVIEHLK--QKKTMT------------- 2735

  Fly   256 NFESPSTRRGDLTHEDASNYKINYTRWLVFCHVPAFCNSLRQCETSLVFGRTLLRTVFQCMSQQL 320
                |:.|..:             .|.:|       ||.:.         :.:|..:.:...|..
Mouse  2736 ----PAEREEN-------------QRMIV-------CNQVM---------KYILDKIDKEEKQAA 2767

  Fly   321 KKKCISERDRFPEDKRS------IITLMPKFLETLRAELLKDDSPIWDTSYRPSNSFVIQ----- 374
            ||:   :|:...|.|||      :..|:.|..|.|:||:|:..:.:       .....||
Mouse  2768 KKR---KREESVEQKRSKQNASKLSALLFKHKEQLKAEILRKRALL-------DKELQIQVQEEL 2822

  Fly   375 ----QRKRNQEVANVPIGPSAASIGGNKRTSVGEPLHKRIKKEP-----TDRPSSENLD------ 424
                :.||.:|:|.. :..:|||:   ...||..|:.......|     :..||:.:|.
Mouse  2823 KRDLKMKREREMAQA-VQANAASV---PTPSVPAPVPAPAPAAPPAPPRSPPPSTHSLPPAGHPT 2883

  Fly   425 -DLPADVVMRAMKSVSESKTTNKAEILFPVNVSRDENVKAEEQKRAIEFHVVGNSLTKPVDKQTV 488
             .||.....|..:...:||:..|..|          :..::|.|:....:.:..:   |.|:.
Mouse  2884 APLPVTSQKRKREEEKDSKSKKKKMI----------STTSKEAKKDTRLYCICKT---PYDES-- 2933

  Fly   489 LWLLGLQLVFAYQLPEMPREYIS-QLVFDTKHKTLALIKENQPIGGICFRPFPSQGFTEIVFCAV 552
                              :.||. .|..:..|             |.|.      |.||
Mouse  2934 ------------------KFYIGCDLCTNWYH-------------GECV------GITE------ 2955

  Fly   553 TMSEQVKGYGTHLMNHLKDYSIQRGIKHLLTFADCDAIGYFKKQGFSKDIK-LARPVYAGYIKEY 616
               ::.|....::.|                  ||..    .::|.|:::. :.|..|.
Mouse  2956 ---KEAKKMDVYICN------------------DCKR----AQEGSSEELYCICRTPYD------ 2989

  Fly   617 DSATLMHCELHPSIVNTQFIAVIRSQSEILKELIAQRHNEVQKVRPGLTCFKEGLPVIPVESIPG 681
            :|...:.|:...:..:.:.:.:::|:::::.|.:..:....:.....||
Mouse  2990 ESQFYIGCDRCQNWYHGRCVGILQSEADLIDEYVCPQCQSTEDAMTVLT---------------- 3038

  Fly   682 LREIGWKPQNRPARSSRPLEESTDPEKLATSFASVLQSVRQHTTAWPFLRPVTAAEVPDYYDHIK 746
                             ||.|. |.|.|    ..||:|::.|..|||||.||...:.||||..||
Mouse  3039 -----------------PLTEK-DYEGL----KRVLRSLQAHKMAWPFLEPVDPNDAPDYYGVIK 3081

  Fly   747 YPMDLKTMGERLKKGYYQTRRLFMADMARIFSNCRFYNSPDTEYYRCANSLERYFQTKMR 806
            .||||.||.||::|.||:....|:|||.:||.|||:||..||.:|:||..||.:|..|::
Mouse  3082 EPMDLATMEERIQKRYYEKLTEFVADMTKIFDNCRYYNPRDTPFYQCAEVLESFFVQKLK 3141

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gcn5	NP_648586.2	PCAF_N	73..322	CDD:283997	34/252 (13%)
		COG5076	451..807	CDD:227408	81/358 (23%)
		Acetyltransf_1	526..598	CDD:278980	9/71 (13%)
		Bromo_gcn5_like	708..808	CDD:99941	49/99 (49%)
Bptf	XP_006532738.1	DDT	253..309	CDD:367184
		WHIM1	356..393	CDD:373966
		PHD1_BPTF	404..446	CDD:277034
		WSD	468..536	CDD:373967
		MDN1	<578..749	CDD:227596
		DUF5585	<2038..2345	CDD:375359
		Med15	<2246..>2609	CDD:312941	13/75 (17%)
		TPH	2696..>2836	CDD:372768	38/206 (18%)
		PHD2_3_BPTF	2923..2969	CDD:277035	13/114 (11%)
		PHD2_3_BPTF	2981..3027	CDD:277035	6/51 (12%)
		Bromo_gcn5_like	3043..3143	CDD:99941	51/104 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810