DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gcn5 and Kat2b

DIOPT Version :9

Sequence 1:	NP_648586.2	Gene:	Gcn5 / 39431	FlyBaseID:	FBgn0020388	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	NP_064389.2	Gene:	Kat2b / 18519	MGIID:	1343094	Length:	813	Species:	Mus musculus

Alignment Length:	849	Identity:	387/849 - (45%)
Similarity:	540/849 - (63%)	Gaps:	79/849 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 GGPSITIKSQPIDGNNTGNAAAQQQQQAANGAATAGASGAAGSAQNPGHGGAASGAGSVPAEGTR 67
            |..|..:...|..|:....|.| ....|:.|.|||.|  |||:|:.||.||:|
Mouse     6 GAGSPALPPAPPHGSPRTLATA-AGSSASCGPATAVA--AAGTAEGPGGGGSA------------ 55

  Fly    68 QNSLQRIQQRKQKVFNLPVPQKLAKLSMYSACQS-EGCRCTGWKTPQEN---RHRDVESSYCPEF 128
                 ||..:|.::.:.|..:||.||.:||||:: |.|:|.|||.|..:   ...|:: ......
Mouse    56 -----RIAVKKAQLRSAPRAKKLEKLGVYSACKAEESCKCNGWKNPNPSPTPPRGDLQ-QIIVSL 114

  Fly   129 NEECRNTSCRHSLRSHIAHLDNISSSSMNELLGAIIDMENLFMSMQRVEDEDTKKVYQYLFRLLR 193
            .|.||  ||.|:|.:|::||:|:|...|:.|||.::|:|.||..:.:.||.|||:||.|||:|||
Mouse   115 TESCR--SCSHALAAHVSHLENVSEEEMDRLLGIVLDVEYLFTCVHKEEDADTKQVYFYLFKLLR 177

  Fly   194 QCVLTRQQAVIRGPL-GDPPFETPCITKAVLSLVFYKYNHLSTPELQTMTEVAKTFLNFLNHYNF 257
            :.:|.|.:.|:.|.| ..||||.|.|.:.|.:.|.||::||.:.|.||..|:||.|||.:|:::.
Mouse   178 KSILQRGKPVVEGSLEKKPPFEKPSIEQGVNNFVQYKFSHLPSKERQTTIELAKMFLNRINYWHL 242

  Fly   258 ESPSTRRGDLTHEDASNYKINYTRWLVFCHVPAFCNSLRQCETSLVFGRTLLRTVFQCMSQQLKK 322
            |:||.||....::|.|.||.||||||.:|:||.||:||.:.||:.||||||||:||..|.:||.:
Mouse   243 EAPSQRRLRSPNDDISGYKENYTRWLCYCNVPQFCDSLPRYETTKVFGRTLLRSVFTIMRRQLLE 307

  Fly   323 KCISERDRFPEDKRS-IITLMPKFLETLRAELLKDDSPIWDTSYRPSNSFVIQQRKRN-----QE 381
            :...|:|:.|.:||: |:|..||||..|..|:...:|||||..:..::|       |.     |.
Mouse   308 QARQEKDKLPLEKRTLILTHFPKFLSMLEEEVYSQNSPIWDQDFLSASS-------RTSPLGIQT 365

  Fly   382 VANVPI---------GPSAASIGGNKRTSVG---------EPLHKRIKKE---PTDRPSSENLDD 425
            |.:.|:         ..|...|.|. |||.|         .|..||....   |.:...|..:.|
Mouse   366 VISPPVTGTALFSSNSTSHEQINGG-RTSPGCRGSSGLEANPGEKRKMNNSHAPEEAKRSRVMGD 429

  Fly   426 LPADVVMRAMKSVSESKTTNKAEILFP------VNVSRDENVKAEEQKRAIEFHVVGNSLTKPVD 484
            :|.:::...|.::     |:.|.:|.|      .:.:|||..:.||::..||||||||||.:..:
Mouse   430 IPVELINEVMSTI-----TDPAGMLGPETNFLSAHSARDEAARLEERRGVIEFHVVGNSLNQKPN 489

  Fly   485 KQTVLWLLGLQLVFAYQLPEMPREYISQLVFDTKHKTLALIKENQPIGGICFRPFPSQGFTEIVF 549
            |:.::||:|||.||::|||.||:|||::||||.|||||||||:.:.|||||||.|||||||||||
Mouse   490 KKILMWLVGLQNVFSHQLPRMPKEYITRLVFDPKHKTLALIKDGRVIGGICFRMFPSQGFTEIVF 554

  Fly   550 CAVTMSEQVKGYGTHLMNHLKDYSIQRGIKHLLTFADCDAIGYFKKQGFSKDIKLARPVYAGYIK 614
            ||||.:|||||||||||||||:|.|:..|.:.||:||..||||||||||||:||:.:..|.||||
Mouse   555 CAVTSNEQVKGYGTHLMNHLKEYHIKHEILNFLTYADEYAIGYFKKQGFSKEIKIPKTKYVGYIK 619

  Fly   615 EYDSATLMHCELHPSIVNTQFIAVIRSQSEILKELIAQRHNEVQKVRPGLTCFKEGLPVIPVESI 679
            :|:.||||.|||:|.|..|:|..:|:.|.||:|:||.::..:::||.|||:|||:|:..||:|||
Mouse   620 DYEGATLMGCELNPQIPYTEFSVIIKKQKEIIKKLIERKQAQIRKVYPGLSCFKDGVRQIPIESI 684

  Fly   680 PGLREIGWKPQNRPARSSRPLEESTDPEKLATSFASVLQSVRQHTTAWPFLRPVTAAEVPDYYDH 744
            ||:||.||||..: .:|..|    .|||:|.::..::||.|:.|..||||:.||...|.|.||:.
Mouse   685 PGIRETGWKPSGK-EKSKEP----KDPEQLYSTLKNILQQVKNHPNAWPFMEPVKRTEAPGYYEV 744

  Fly   745 IKYPMDLKTMGERLKKGYYQTRRLFMADMARIFSNCRFYNSPDTEYYRCANSLERYFQTKMRELG 809
            |::|||||||.|||:..||.:::|||||:.|:|:||:.||.|::|||:||:.||::|.:|::|.|
Mouse   745 IRFPMDLKTMSERLRNRYYVSKKLFMADLQRVFTNCKEYNPPESEYYKCASILEKFFFSKIKEAG 809

  Fly   810 LWDK 813
            |.||
Mouse   810 LIDK 813

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gcn5	NP_648586.2	PCAF_N	73..322	CDD:283997	117/253 (46%)
		COG5076	451..807	CDD:227408	203/361 (56%)
		Acetyltransf_1	526..598	CDD:278980	53/71 (75%)
		Bromo_gcn5_like	708..808	CDD:99941	49/99 (49%)
Kat2b	NP_064389.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55		20/51 (39%)
		PCAF_N	56..307	CDD:283997	117/253 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	380..423		11/43 (26%)
		COG5076	468..807	CDD:227408	199/343 (58%)
		Acetyltransf_1	531..603	CDD:278980	53/71 (75%)
		Acetyl-CoA binding. /evidence=ECO:0000250\|UniProtKB:Q92830	555..557		1/1 (100%)
		Acetyl-CoA binding. /evidence=ECO:0000250\|UniProtKB:Q92830	562..568		5/5 (100%)
		Acetyl-CoA binding. /evidence=ECO:0000250\|UniProtKB:Q92830	593..596		1/2 (50%)
		Bromo_gcn5_like	708..807	CDD:99941	49/98 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	240	1.000	Domainoid score	I2253
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	725	1.000	Inparanoid score	I621
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49011
OrthoDB	1	1.010	-	-		D180844at33208
OrthoFinder	1	1.000	-	-		FOG0002578
OrthoInspector	1	1.000	-	-		otm43412
orthoMCL	1	0.900	-	-		OOG6_101489
Panther	1	1.100	-	-	LDO	PTHR45750
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R479
SonicParanoid	1	1.000	-	-		X1691
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.870