DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gcn5 and cbp-1

DIOPT Version :9

Sequence 1:	NP_648586.2	Gene:	Gcn5 / 39431	FlyBaseID:	FBgn0020388	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	NP_499160.2	Gene:	cbp-1 / 176380	WormBaseID:	WBGene00000366	Length:	2017	Species:	Caenorhabditis elegans

Alignment Length:	902	Identity:	175/902 - (19%)
Similarity:	274/902 - (30%)	Gaps:	330/902 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSGGPSITIKSQPIDGNN------TGN----------------AAAQ---QQQQAANGAATAGA- 39
            |..|..:....|||.|.|      .|:                ||||   |||.||...|.|.|
Worm   299 MHQGMMMDSNGQPIRGPNQMMMMSNGHPGMSHGPPNGQPGPQAAAAQHAAQQQAAAQAQAQAAAQ 363

  Fly    40 --------SGAAGSAQNPGHGGAASGAGSVPAEGTRQNSLQRIQQRKQKVFNLPVPQKLAKLSMY 96
                    ..||.:||..|.|.|.:...|:.|  |.|:               |..:||.:..:.
Worm   364 QQQQQQREQEAAAAAQRNGAGRATTPGSSMLA--THQD---------------PEKRKLIQQQLV 411

  Fly    97 SACQSEGCRCTGWKTPQENRHRDVESSYCPEFNEECRNTSCRHSLRSHIAHLDNISSSSMNELLG 161
            ....:..|      :.:|..:||..:...|..:..|....| .:::..:.|:     :|.|  :|
Worm   412 LLLHAHKC------SQREKENRDFAAKNQPPPHAACTLPHC-STMKEVLTHM-----TSCN--VG 462

  Fly   162 AIIDMENLFMSMQRVEDEDTKKVYQYLFRLLRQCV-----LTRQQAVIRGPL---GDPPFETPCI 218
            .:...:.         .:.|||.........||.:     .:|:...:..||   .|.|.:
Worm   463 RLCHSDT---------TQTTKKCSVAHCASSRQIIAHWKNCSREDCPVCKPLKRIQDTPLQ---- 514

  Fly   219 TKAVLSLVFYKYNHLSTPELQTMTEVAKTFLNFLNHYNFESPSTRRGDLTHEDASNYKINYTRWL 283
                          .|.|:|..:..|           |..|..:..||..|:
Worm   515 --------------FSLPDLANLIGV-----------NGNSNGSAEGDGLHQ------------- 541

  Fly   284 VFCHVPAFCNSLRQCETSLVFGRTLLRTVFQCMSQQLKKKCISERDRFPEDKRSIITLMPKFLET 348
                                ||...:||
Worm   542 --------------------FGSPAMRT------------------------------------- 549

  Fly   349 LRAELLKDDSPIWDTSYRPSNSFVIQQRKR---------NQEVANVPIG--PSAASIGGNKRTS- 401
                     ..|.::.:...|....|....         |.|:.|:|..  |.......::.|.
Worm   550 ---------GNITNSLFEGFNGNPFQNGPNRGGPRPPGGNGEIPNLPPPDMPDCTKEWHHQVTKD 605

  Fly   402 -----VGEPLHKRIKKEPTDRPSSEN-LDDLPADVVMRAMKSVSESKTTNKAEILFPVNVSRDEN 460
                 ||: |.|.|..||.....::| |.||.| ...:..|.:.||  .|..|..:.:...:...
Worm   606 LRNHLVGK-LVKAIFPEPNQEAMNDNRLKDLIA-YARKVEKEMFES--ANDREEYYHLLAEKIYK 666

  Fly   461 VKAEEQKRAIEFHVVGNSLTKPVDKQTVLWLLGLQLVFAYQLPEMPREYISQLV----------F 515
            ::.|.|::.       ||....          |......|.:|  |...::|::          .
Worm   667 IQKELQEKK-------NSRLNQ----------GAAAHDQYAIP--PSNELAQMLGVEGGRSDVHS 712

  Fly   516 DTKHKTLALIKENQPIGGICFRP----------------------FPSQG-FTEIVFCAVTMSEQ 557
            :.....:|..::|||.||   .|                      |||.| .|..:..:.|:|..
Worm   713 EGSSMAVAPSQQNQPWGG---APNSNMHQQIPPNGQVPQVNNSSTFPSSGNSTPNIGASSTVSAM 774

  Fly   558 VKGYGTHLMNHLKDYSIQRGIKHLLTFADCDAIGYFKKQGFSKDIKLARPVYAGYIKEYDSATLM 622
            ::. .|..|:.....|        |:.....|||:    |.|.....| |:..|.:|:.:.....
Worm   775 LQP-KTEPMDDQNTDS--------LSSRPPTAIGF----GGSSSSTPA-PIMNGIVKKEEDPEES 825

  Fly   623 HCELHPSIVNTQFIAVIRSQSEILKELIAQRHNEVQKVRPGLTCFKEGLPVIPVESIPGLREIGW 687
            ..:..||:.:|                                  |:|:    .||.|
Worm   826 SNQAPPSVKDT----------------------------------KDGV----AESKP------- 845

  Fly   688 KPQNRPARSSRPLEEST--DPEKLATSFASVLQSVRQHTTAWPFLRPVTA--AEVPDYYDHIKYP 748
            |.|......:.|..|.|  ..|.|......|.:.:.:...|.||..||.|  ..:|||::.||.|
Worm   846 KEQQAKREPTPPPTEDTVFSQEDLIKFLLPVWEKLDKSEDAAPFRVPVDAKLLNIPDYHEIIKRP 910

  Fly   749 MDLKTMGERLKKGYYQTRRLFMADMARIFSNCRFYNSPDTEYYRCANSLERYFQTKM 805
            |||:|:.::|..|.||....|..|:..:..|...||..:::.|:....|...|.::|
Worm   911 MDLETVHKKLYAGQYQNAGQFCDDIWLMLDNAWLYNRKNSKVYKYGLKLSEMFVSEM 967

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gcn5	NP_648586.2	PCAF_N	73..322	CDD:283997	37/256 (14%)
		COG5076	451..807	CDD:227408	81/392 (21%)
		Acetyltransf_1	526..598	CDD:278980	20/94 (21%)
		Bromo_gcn5_like	708..808	CDD:99941	31/100 (31%)
cbp-1	NP_499160.2	ZnF_TAZ	415..505	CDD:214717	17/112 (15%)
		KIX	593..673	CDD:280354	19/83 (23%)
		Bromo_cbp_like	866..972	CDD:99927	32/102 (31%)
		DUF902	970..1009	CDD:283620
		RING_CBP-p300	984..1067	CDD:276805
		PHD_CBP_p300	1069..1100	CDD:277032
		HAT_KAT11	1131..1427	CDD:295182
		ZZ_CBP	1497..1535	CDD:239077
		ZnF_TAZ	1551..1629	CDD:214717
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910