DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gcn5 and athp-2

DIOPT Version :9

Sequence 1:	NP_648586.2	Gene:	Gcn5 / 39431	FlyBaseID:	FBgn0020388	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	NP_494767.2	Gene:	athp-2 / 173769	WormBaseID:	WBGene00019217	Length:	1412	Species:	Caenorhabditis elegans

Alignment Length:	924	Identity:	169/924 - (18%)
Similarity:	290/924 - (31%)	Gaps:	343/924 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 RKQKVFNLPVPQKLA-------KLSMYS--------------ACQSEGCRCTGWKTPQENRHRDV 120
            |...||:|..|::|.       :|..||              ..:.|..:...|...||......
Worm   637 RTLTVFDLEAPERLEIVKTLIYQLLTYSKFRGHLEQRQNELVELKREQKKLKAWDVGQEGEANAA 701

  Fly   121 E---------SSYCPEFNEECRNTSCRHSLRSHIAHLDNISSSSMNELLGAIIDMENL------- 169
            .         :|..|:..|:......|. |::||        .::||  |...|.|:|
Worm   702 RLLLELAPAGASGAPDVKEQKEPPVVRR-LKAHI--------KAINE--GRRYDKEDLDAIVLES 755

  Fly   170 --FMSMQRVEDEDTKKVYQYLFRLLRQCVLTRQQAV------IRGPLGDPPFETPCITKAVLSLV 226
              :.|:...|....:::.:..|::|...::::...:      ||  ||........|....||.:
Worm   756 VPYASLSLDEIVTARELQKSEFKILMDSLISKMFQIYSKISDIR--LGSDRAYRRYIVMENLSAI 818

  Fly   227 FYKYNHLSTPELQTM------TEVAKTFLNFLNHYNFE------SPSTRRGDLTHEDASNYKINY 279
            .     :.|...|.:      ..:....||.|.:.:.|      :..|.|   .|.|.||   |:
Worm   819 L-----VETATFQELGIYCDEPSIIDDPLNLLENEHQEVFICTGNMDTCR---VHGDESN---NW 872

  Fly   280 TRWLVFCHVPAFCNSLRQCETSLVFGRTLLRTVFQCMSQQLKKKCISERDRFPEDKRSIITLMPK 344
            |||                                        ..|.:|::|.:..:|   |.|:
Worm   873 TRW----------------------------------------SYIRDREQFEQLLKS---LNPR 894

  Fly   345 FLETLRAELLKDDSPIWDTSYRPSNSFVIQQRKRNQEVANVPIGPSAASIGGNKRTSVGEPLHKR 409
              .....|||::.:     .||||...::::.:|                           ||:.
Worm   895 --GNREVELLEELN-----EYRPSLLEILEETER---------------------------LHEE 925

  Fly   410 IKKEP-------TDRPSSENLDDLPADVVMR-------------AMKSVSESKTTNKAE------ 448
            .:.|.       |:.|:..:..::..|..||             .|.|:.:....|:.|
Worm   926 EEDEDEWKSQFMTNDPNPGDTYNIDWDAEMRDLLLDFEEKIDQGQMGSIEKIFECNRIEWRDNLK 990

  Fly   449 --------------ILFPVNVSRDENVK-AEEQKRAIEFHVVGNSLTKPVDKQTVLWLLGLQLVF 498
                          |...::|:.:|:.. ::..|.||.|:::..|             :.|:.:.
Worm   991 ESGNVCMLLNEDISIFGEISVNLEESEHFSDSMKLAIAFYMIIKS-------------IHLKFIK 1042

  Fly   499 A-YQLPE-------MPREYISQ----LVFDTKHKTLALIKENQPIGGICFRPFPSQGFTEIVFCA 551
            | |..|.       .|.|...:    |:....|..|:|              |.|
Worm  1043 APYISPNKDEHGNLKPSELFIRWQRALLECESHSALSL--------------FIS---------- 1083

  Fly   552 VTMSEQVKGYGTHLMNHLKDYSIQRGIKHLLTFADCDAIGYFKKQGFSKDIKLARPVYAGYIKEY 616
             |....:|...:.|....:....:.....|:..::||...:.|..  ..|:....|  |.::
Worm  1084 -TFEGSIKWDKSRLQGKCRSCRRKAAAHDLVLCSECDNCYHLKCA--KLDVNSDAP--ADWM--- 1140

  Fly   617 DSATLMHCELHPSIVNTQFIAVIRSQSEILKE-----------LIAQRHNEV--QKVRPGLTC-- 666
                ...|......|..:...:.|...::.:.           .|:...:|:  :...|..:|
Worm  1141 ----CTSCRAQQRKVENEAKRMARDDDQLAESSSQEDVAIGNISISDNFSEIAPKTAEPAESCST 1201

  Fly   667 ---FKEGLPVIPVESIPGLREI-------GWKPQNRPARSSRPL--------------------- 700
               .||. |.|...|...::.:       |...:||.:..|.|:
Worm  1202 PTTSKEP-PTIRTASGRAVKRVHYSDIHEGLSLKNRKSNGSMPVTPSERPVRNVSVRIFDVENEN 1265

  Fly   701 ----EESTDPE-----KLATSFASV---------------------------LQSVRQHTTAWPF 729
                |:.:|.|     |..||..||                           |:...:...:|||
Worm  1266 VLTDEDDSDGENTRKRKTPTSKKSVTSTPTTNDISRVIIPNIKEKMTLIETLLKEAMRQECSWPF 1330

  Fly   730 LRPVTAAEVPDYYDHIKYPMDLKTMGERLKKGYYQTRRLFMADMARIFSNCRFYNSPDTEYYRCA 794
            |:||.:.|||||||.||.||:|:||..::|:..|........|...|.|||..||.|:.|.|:.:
Worm  1331 LQPVDSKEVPDYYDVIKRPMNLRTMMNKIKQRIYNKPIEVRNDFQLILSNCETYNEPENEIYKLS 1395

  Fly   795 NSLERYFQTKMREL 808
            ..|..:...::.|:
Worm  1396 RELHDFMADRLDEI 1409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gcn5	NP_648586.2	PCAF_N	73..322	CDD:283997	53/301 (18%)
		COG5076	451..807	CDD:227408	88/450 (20%)
		Acetyltransf_1	526..598	CDD:278980	9/71 (13%)
		Bromo_gcn5_like	708..808	CDD:99941	39/126 (31%)
athp-2	NP_494767.2	WAC_Acf1_DNA_bd	23..123	CDD:402251
		DDT	457..524	CDD:214726
		WHIM1	629..671	CDD:406127	9/33 (27%)
		WSD	795..897	CDD:406128	29/159 (18%)
		PHD	1100..1144	CDD:214584	7/54 (13%)
		BROMO	1306..1409	CDD:197636	34/102 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810