DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gcn5 and pcaf-1

DIOPT Version :9

Sequence 1:	NP_648586.2	Gene:	Gcn5 / 39431	FlyBaseID:	FBgn0020388	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	NP_491173.1	Gene:	pcaf-1 / 171920	WormBaseID:	WBGene00021636	Length:	767	Species:	Caenorhabditis elegans

Alignment Length:	781	Identity:	253/781 - (32%)
Similarity:	381/781 - (48%)	Gaps:	103/781 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 QKLAKLSMYSACQSEGCRCTGWKTPQENRHRDV-----------ESSYCPEFNE----------E 131
            :|..:|:.:::|.:..|:|.|:: |..| |.|.           |:.:.|...:          |
Worm     9 EKRRQLTYFTSCNAGTCQCRGFR-PVLN-HEDETVERRATRAERENDFAPMTRDLETLGSEEIIE 71

  Fly   132 CRNTSCRHSLRSHIAHLDNISSSSMNELLGAIIDMENLFMSMQRVE--DEDTKKVY---QYLFRL 191
            ||  :|.||:..|...|..:|...::.....|.|::.....:..::  .|..:.:|   |.|.:.
Worm    72 CR--TCGHSISFHAEPLKYLSQEDLDTYTDQISDLQTCCSELSEIDPSHESLQTLYITMQILLKS 134

  Fly   192 LRQCVLTRQQAVIRGPLGDPPFETPCITKAVLSLVFYKYNHLSTPELQTMTEVAKTFLNFLNHYN 256
            ||  .||......   :|.|.||...::..:|...|.....:...|.|.:.|:...||..:||:.
Worm   135 LR--TLTPVDVPF---IGKPNFEPESLSPYILVKKFIASRPVDNAEKQRLAEIGTLFLTEMNHWK 194

  Fly   257 FESPSTRRGDLTHE-DASNYKINYTRWLVFCHVPAFCNSLRQCETSLVFGRTLLRTVFQCMSQQL 320
            .|...:....|... :...|::.|.|...:.::||...|.:|.:|..:||.....|....:...|
Worm   195 LEGFQSLADKLNVPLEQGKYRMMYVRMDYYVNMPAKYVSFKQFQTVDIFGEKFTTTFCNYLINVL 259

  Fly   321 KKK-----CISERDRFPEDKRSIITLMPKFLETLRAELLKDDSPIWDTSYRPSNSF-----VIQQ 375
            ...     .:||.| ..|:...:||    |...||..|..:|.....|:.|..:|.     :::.
Worm   260 NTGNYTPFGLSESD-LEENSEDLIT----FATDLRRYLETEDPQSTSTTNRRKDSISTEDVILKY 319

  Fly   376 RKRNQEVANVPIGPSAASIGGNKRTS-VGEPLHKRIKKEPTD----RPSSENLDDLPADVVMRAM 435
            .||.:     |...|.:|......|| |.||  :|.||||:.    .|.:|....|...:: ||:
Worm   320 VKRKK-----PTDHSESSSPRELSTSPVEEP--RRRKKEPSSSAKKSPETEESMALLRSLI-RAI 376

  Fly   436 K-----SVSESKTTNKAEILFPVNVSRDENVKAEEQKRAIEFHVVGNSLTKPVDKQTVLWLLGLQ 495
            |     ...|.||..:.|.| ...|||..:...||:...|||.|:||.|......:.::.|:.||
Worm   377 KFEGDLDAMEPKTKVEFEAL-NTEVSRGLSALQEEESGLIEFRVIGNDLDPFQHHEQLVHLVELQ 440

  Fly   496 LVFAYQLPEMPREYISQLVFDTKHKTLALIKENQ-PIGGICFRPFPSQGFTEIVFCAVTMSEQVK 559
            .:|..|||:||:||:::|:||::|:.:.::|.:. .|||||||.|||:||.||||||:|..||||
Worm   441 NLFGAQLPKMPKEYVTRLIFDSRHQNMVILKRDMGVIGGICFRTFPSRGFVEIVFCAITAMEQVK 505

  Fly   560 GYGTHLMNHLKDYSIQRGIKHLLTFADCDAIGYFKKQGFSKDIKLARPVYAGYIKEYDSATLMHC 624
            |||||||||.|||.|:..|.|:||:||..|||||.|||||:.:::...||.|:||||:.||||.|
Worm   506 GYGTHLMNHCKDYMIKNKIYHMLTYADEFAIGYFTKQGFSEKLEINDTVYQGWIKEYEGATLMGC 570

  Fly   625 ELHPSIVNTQFIAVIRSQSEILKELIA-----QRHNEVQ---KVRPGLT-CFKEGLP-VIPVESI 679
            .|||.|..|:|       .:..|.:.|     :..|..:   ||..||. .|:|..| ::.:..:
Worm   571 HLHPQISYTKF-------PDFSKGIQALHCGYKSENGAESRGKVFGGLEHLFRESSPQLLELRKV 628

  Fly   680 PGLREIGWKPQNRPARSSRPLEESTDPEKLATSFASVLQSVRQHTTAWPFLRPVTAAEVPDYYDH 744
            ||...:     ....:|...|:|..|  .|.:...::|:.:.....||||..||...|||:||||
Worm   629 PGTDSL-----KMHKKSCYHLDERDD--SLDSKIGAILKKLTADKNAWPFASPVDVKEVPEYYDH 686

  Fly   745 IKYPMDLKTMGERLKKGYYQTRRLFMADMARIFSNCRFYNSPDTEYYRCANSLERYFQTKMRELG 809
            ||:|:|.|||.|:||:..|..:.||:||:.|:|.||..:|..:..||:        :..|:.||.
Worm   687 IKHPIDFKTMQEKLKRKAYTHQHLFIADLNRLFQNCYVFNGAEAVYYK--------YGYKLNELA 743

  Fly   810 L 810
            |
Worm   744 L 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gcn5	NP_648586.2	PCAF_N	73..322	CDD:283997	58/260 (22%)
		COG5076	451..807	CDD:227408	152/366 (42%)
		Acetyltransf_1	526..598	CDD:278980	50/72 (69%)
		Bromo_gcn5_like	708..808	CDD:99941	38/99 (38%)
pcaf-1	NP_491173.1	PCAF_N	9..247	CDD:283997	56/246 (23%)
		COG5076	408..735	CDD:227408	148/348 (43%)
		Acetyltransf_1	476..544	CDD:278980	49/67 (73%)
		Bromo_gcn5_like	650..748	CDD:99941	41/103 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167419
Domainoid	1	1.000	120	1.000	Domainoid score	I3572
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	329	1.000	Inparanoid score	I1445
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49011
OrthoDB	1	1.010	-	-		D180844at33208
OrthoFinder	1	1.000	-	-		FOG0002578
OrthoInspector	1	1.000	-	-		oto19096
orthoMCL	1	0.900	-	-		OOG6_101489
Panther	1	1.100	-	-	LDO	PTHR45750
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R479
SonicParanoid	1	1.000	-	-		X1691
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.800