Protein Alignment Gcn5 and pcaf-1

DIOPT Version :10

• Sequence 1: NP_648586.2
• Gene: Gcn5 / 39431
• FlyBaseID: FBgn0020388
• Length: 813
• Species: Drosophila melanogaster
• Sequence 2: NP_491173.1
• Gene: pcaf-1 / 171920
• WormBaseID: WBGene00021636
• Length: 767
• Species: Caenorhabditis elegans
• Alignment Length: 781
• Identity: 253/781 - (32%)
• Similarity: 381/781 - (48%)
• Gaps: 103/781 - (13%)

  Fly    88 QKLAKLSMYSACQSEGCRCTGWKTPQENRHRDV-----------ESSYCPEFNE----------E 131
            :|..:|:.:::|.:..|:|.|:: |..| |.|.           |:.:.|...:          |
 Worm     9 EKRRQLTYFTSCNAGTCQCRGFR-PVLN-HEDETVERRATRAERENDFAPMTRDLETLGSEEIIE 71

  Fly   132 CRNTSCRHSLRSHIAHLDNISSSSMNELLGAIIDMENLFMSMQRVE--DEDTKKVY---QYLFRL 191
            ||  :|.||:..|...|..:|...::.....|.|::.....:..::  .|..:.:|   |.|.:.
 Worm    72 CR--TCGHSISFHAEPLKYLSQEDLDTYTDQISDLQTCCSELSEIDPSHESLQTLYITMQILLKS 134

  Fly   192 LRQCVLTRQQAVIRGPLGDPPFETPCITKAVLSLVFYKYNHLSTPELQTMTEVAKTFLNFLNHYN 256
            ||  .||......   :|.|.||...::..:|...|.....:...|.|.:.|:...||..:||:.
 Worm   135 LR--TLTPVDVPF---IGKPNFEPESLSPYILVKKFIASRPVDNAEKQRLAEIGTLFLTEMNHWK 194

  Fly   257 FESPSTRRGDLTHE-DASNYKINYTRWLVFCHVPAFCNSLRQCETSLVFGRTLLRTVFQCMSQQL 320
            .|...:....|... :...|::.|.|...:.::||...|.:|.:|..:||.....|....:...|
 Worm   195 LEGFQSLADKLNVPLEQGKYRMMYVRMDYYVNMPAKYVSFKQFQTVDIFGEKFTTTFCNYLINVL 259

  Fly   321 KKK-----CISERDRFPEDKRSIITLMPKFLETLRAELLKDDSPIWDTSYRPSNSF-----VIQQ 375
            ...     .:||.| ..|:...:||    |...||..|..:|.....|:.|..:|.     :::.
 Worm   260 NTGNYTPFGLSESD-LEENSEDLIT----FATDLRRYLETEDPQSTSTTNRRKDSISTEDVILKY 319

  Fly   376 RKRNQEVANVPIGPSAASIGGNKRTS-VGEPLHKRIKKEPTD----RPSSENLDDLPADVVMRAM 435
            .||.:     |...|.:|......|| |.||  :|.||||:.    .|.:|....|...:: ||:
 Worm   320 VKRKK-----PTDHSESSSPRELSTSPVEEP--RRRKKEPSSSAKKSPETEESMALLRSLI-RAI 376

  Fly   436 K-----SVSESKTTNKAEILFPVNVSRDENVKAEEQKRAIEFHVVGNSLTKPVDKQTVLWLLGLQ 495
            |     ...|.||..:.|.| ...|||..:...||:...|||.|:||.|......:.::.|:.||
 Worm   377 KFEGDLDAMEPKTKVEFEAL-NTEVSRGLSALQEEESGLIEFRVIGNDLDPFQHHEQLVHLVELQ 440

  Fly   496 LVFAYQLPEMPREYISQLVFDTKHKTLALIKENQ-PIGGICFRPFPSQGFTEIVFCAVTMSEQVK 559
            .:|..|||:||:||:::|:||::|:.:.::|.:. .|||||||.|||:||.||||||:|..||||
 Worm   441 NLFGAQLPKMPKEYVTRLIFDSRHQNMVILKRDMGVIGGICFRTFPSRGFVEIVFCAITAMEQVK 505

  Fly   560 GYGTHLMNHLKDYSIQRGIKHLLTFADCDAIGYFKKQGFSKDIKLARPVYAGYIKEYDSATLMHC 624
            |||||||||.|||.|:..|.|:||:||..|||||.|||||:.:::...||.|:||||:.||||.|
 Worm   506 GYGTHLMNHCKDYMIKNKIYHMLTYADEFAIGYFTKQGFSEKLEINDTVYQGWIKEYEGATLMGC 570

  Fly   625 ELHPSIVNTQFIAVIRSQSEILKELIA-----QRHNEVQ---KVRPGLT-CFKEGLP-VIPVESI 679
            .|||.|..|:|       .:..|.:.|     :..|..:   ||..||. .|:|..| ::.:..:
 Worm   571 HLHPQISYTKF-------PDFSKGIQALHCGYKSENGAESRGKVFGGLEHLFRESSPQLLELRKV 628

  Fly   680 PGLREIGWKPQNRPARSSRPLEESTDPEKLATSFASVLQSVRQHTTAWPFLRPVTAAEVPDYYDH 744
            ||...:     ....:|...|:|..|  .|.:...::|:.:.....||||..||...|||:||||
 Worm   629 PGTDSL-----KMHKKSCYHLDERDD--SLDSKIGAILKKLTADKNAWPFASPVDVKEVPEYYDH 686

  Fly   745 IKYPMDLKTMGERLKKGYYQTRRLFMADMARIFSNCRFYNSPDTEYYRCANSLERYFQTKMRELG 809
            ||:|:|.|||.|:||:..|..:.||:||:.|:|.||..:|..:..||:        :..|:.||.
 Worm   687 IKHPIDFKTMQEKLKRKAYTHQHLFIADLNRLFQNCYVFNGAEAVYYK--------YGYKLNELA 743

  Fly   810 L 810
            |
 Worm   744 L 744

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gcn5	NP_648586.2	PCAF_N	73..320	CDD:461923	57/258 (22%)
		COG5076	451..807	CDD:227408	152/366 (42%)
		Bromo_gcn5_like	708..808	CDD:99941	38/99 (38%)
pcaf-1	NP_491173.1	PCAF_N	6..247	CDD:461923	56/246 (23%)
		COG5076	408..735	CDD:227408	148/348 (43%)
		Bromo_gcn5_like	650..748	CDD:99941	41/103 (40%)