DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gcn5 and Kat2a

DIOPT Version :9

Sequence 1:	NP_648586.2	Gene:	Gcn5 / 39431	FlyBaseID:	FBgn0020388	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	XP_017169759.2	Gene:	Kat2a / 14534	MGIID:	1343101	Length:	907	Species:	Mus musculus

Alignment Length:	831	Identity:	380/831 - (45%)
Similarity:	531/831 - (63%)	Gaps:	70/831 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 ATAGASGAAGSAQNPGHGGAASGAGSVPAE-GTRQNSLQRIQQRKQKVFNLPVPQKLAKLSMYSA 98
            |.|.|:..|||.   |.|||..|:|..||. |..|.  ||..|||.:|..||..:||.||.::||
Mouse    95 APAPAAAPAGST---GSGGAGVGSGGDPARPGLSQQ--QRASQRKAQVRGLPRAKKLEKLGVFSA 154

  Fly    99 CQ-SEGCRCTGWKTPQENR--HRDVESSYCPEFNEECRNTSCRHSLRSHIAHLDNISSSSMNELL 160
            |: :|.|:|.|||.|:...  ..|::.. ....:|.||  ||.|.|..|::||:|:|...:|.||
Mouse   155 CKANETCKCNGWKNPKPPTAPRMDLQQP-AANLSELCR--SCEHPLADHVSHLENVSEDEINRLL 216

  Fly   161 GAIIDMENLFMSMQRVEDEDTKKVYQYLFRLLRQCVLTRQQAVIRGPLGDPPFETPCITKAVLSL 225
            |.::|:||||||:.:.||.|||:||.|||:|||:|:|...:.|:.|.||.||||.|.|.:.||:.
Mouse   217 GMVVDVENLFMSVHKEEDTDTKQVYFYLFKLLRKCILQMTRPVVEGSLGSPPFEKPNIEQGVLNF 281

  Fly   226 VFYKYNHLSTPELQTMTEVAKTFLNFLNHYNFESPSTRRGDLTHEDASNYKINYTRWLVFCHVPA 290
            |.||::||:..|.|||.|::|.||..||::..|:|:..|.....||.:.||:||||||.:||||.
Mouse   282 VQYKFSHLAPRERQTMFELSKMFLLCLNYWKLETPAQFRQRSQSEDVATYKVNYTRWLCYCHVPQ 346

  Fly   291 FCNSLRQCETSLVFGRTLLRTVFQCMSQQLKKKCISERDRF-PEDKRSIITLMPKFLETLRAELL 354
            .|:||.:.||:.||||:|||::|....:||.:|...|:|:. ||.:..|:|..||||..|..|:.
Mouse   347 SCDSLPRYETTHVFGRSLLRSIFTVTRRQLLEKFRVEKDKLVPEKRTLILTHFPKFLSMLEEEIY 411

  Fly   355 KDDSPIWDTSYRPSNSFVIQQRKRNQEVANVPIGPSAASIGGNKRTSVG------EPLHKRIKKE 413
            ..:||||::.:....|...|...|...|:...:...:.|:||...:|:.      ||:....|::
Mouse   412 GANSPIWESGFTMPPSEGTQLVPRPATVSATVVPSFSPSMGGGSNSSLSLDSAGTEPMPAGEKRK 476

  Fly   414 PTDRPSSEN------LDDLPADVVMRAMKSVSESKTTNKAEILFP------VNVSRDENVKAEEQ 466
            ..:..:.|:      :.|:|.::|...|.::     |:.|.:|.|      .|.:|||..:.||:
Mouse   477 LPENLTLEDAKRLRVMGDIPMELVNEVMLTI-----TDPAAMLGPETSLLSANAARDETARLEER 536

  Fly   467 KRAIEFHVVGNSLTKPVDKQTVLWLLGLQLVFAYQLPEMPREYISQLVFDTKHKTLALIKENQPI 531
            :..|||||:|||||...:::.:|||:|||.||::|||.||:|||::||||.|||||||||:.:.|
Mouse   537 RGIIEFHVIGNSLTPKANRRVLLWLVGLQNVFSHQLPRMPKEYIARLVFDPKHKTLALIKDGRVI 601

  Fly   532 GGICFRPFPSQGFTEIVFCAVTMSEQVKGYGTHLMNHLKDYSIQRGIKHLLTFADCDAIGYFKKQ 596
            ||||||.||:||||||||||||.:|||||||||||||||:|.|:..|.:.||:||..||||||||
Mouse   602 GGICFRMFPTQGFTEIVFCAVTSNEQVKGYGTHLMNHLKEYHIKHSILYFLTYADEYAIGYFKKQ 666

  Fly   597 GFSKDIKLARPVYAGYIKEYDSATLMHCELHPSIVNTQFIAVIRSQSEILKELIAQRHNEVQKVR 661
            |||||||:.:..|.||||:|:.||||.|||:|.|..|:...:|:.|.||:|:||.::..:::||.
Mouse   667 GFSKDIKVPKSRYLGYIKDYEGATLMECELNPRIPYTELSHIIKKQKEIIKKLIERKQAQIRKVY 731

  Fly   662 PGLTCFKEGLPVIPVESIPGLR-----------------------------EIGWKPQNRPARSS 697
            |||:|||||:..|||||:||:|                             |.||||..:...
Mouse   732 PGLSCFKEGVRQIPVESVPGIREQGPWLRGQGGILRAWVGILRDAFSPSAGETGWKPLGKEKG-- 794

  Fly   698 RPLEESTDPEKLATSFASVLQSVRQHTTAWPFLRPVTAAEVPDYYDHIKYPMDLKTMGERLKKGY 762
               :|..||::|.|:..::|..::.|.:||||:.||..:|.||||:.|::|:|||||.|||:..|
Mouse   795 ---KELKDPDQLYTTLKNLLAQIKSHPSAWPFMEPVKKSEAPDYYEVIRFPIDLKTMTERLRSRY 856

  Fly   763 YQTRRLFMADMARIFSNCRFYNSPDTEYYRCANSLERYFQTKMRELGLWDK 813
            |.||:||:||:.|:.:|||.||.||:||.|||::||::|..|::|.||.||
Mouse   857 YVTRKLFVADLQRVIANCREYNPPDSEYCRCASALEKFFYFKLKEGGLIDK 907

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gcn5	NP_648586.2	PCAF_N	73..322	CDD:283997	119/251 (47%)
		COG5076	451..807	CDD:227408	203/390 (52%)
		Acetyltransf_1	526..598	CDD:278980	52/71 (73%)
		Bromo_gcn5_like	708..808	CDD:99941	50/99 (51%)
Kat2a	XP_017169759.2	PCAF_N	129..378	CDD:399460	119/251 (47%)
		COG5076	533..902	CDD:227408	198/373 (53%)
		Bromo_gcn5_like	802..901	CDD:99941	50/98 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	240	1.000	Domainoid score	I2253
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41343
Inparanoid	1	1.050	725	1.000	Inparanoid score	I621
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49011
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002578
OrthoInspector	1	1.000	-	-		otm43412
orthoMCL	1	0.900	-	-		OOG6_101489
Panther	1	1.100	-	-	O	PTHR45750
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R479
SonicParanoid	1	1.000	-	-		X1691
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.860