DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Gcn5 and CREBBP

DIOPT Version :9

Sequence 1:NP_648586.2 Gene:Gcn5 / 39431 FlyBaseID:FBgn0020388 Length:813 Species:Drosophila melanogaster
Sequence 2:NP_004371.2 Gene:CREBBP / 1387 HGNCID:2348 Length:2442 Species:Homo sapiens


Alignment Length:183 Identity:50/183 - (27%)
Similarity:88/183 - (48%) Gaps:23/183 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly   639 IRSQSEILKEL-IAQRHNEVQKVRPGLTCFKEGLPVIPVESIPGLREIGWKPQNRPARS----SR 698
            ::..|::.:|. ||::.:|..:|       .|..|.:.||    ::|......|..|..    |:
Human  1026 LQGASQVKEETDIAEQKSEPMEV-------DEKKPEVKVE----VKEEEESSSNGTASQSTSPSQ 1079

  Fly   699 PLEESTDPEKLATSFASVLQSV-RQHTTAWPFLRPV--TAAEVPDYYDHIKYPMDLKTMGERLKK 760
            |.::...||:|..:....|::: ||...:.||.:||  ....:|||:|.:|.||||.|:..:|..
Human  1080 PRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDT 1144

  Fly   761 GYYQTRRLFMADMARIFSNCRFYNSPDTEYYRCANSLERYFQTK----MRELG 809
            |.||....::.|:..:|:|...||...:..|:..:.|...|:.:    |:.||
Human  1145 GQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLG 1197

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gcn5NP_648586.2 PCAF_N 73..322 CDD:283997
COG5076 451..807 CDD:227408 48/179 (27%)
Acetyltransf_1 526..598 CDD:278980
Bromo_gcn5_like 708..808 CDD:99941 31/106 (29%)
CREBBPNP_004371.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..41
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 74..179
Interaction with SRCAP. /evidence=ECO:0000269|PubMed:10347196 227..410
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 266..290
zf-TAZ 363..430 CDD:280324
KIX 587..667 CDD:280354
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 794..1083 15/67 (22%)
Bromo_cbp_like 1087..1194 CDD:99927 32/106 (30%)
Interaction with histone. /evidence=ECO:0000269|PubMed:24361270 1124..1170 18/45 (40%)
Interaction with ASF1A. /evidence=ECO:0000269|PubMed:24616510 1162..1180 4/17 (24%)
RING_CBP-p300 1206..1278 CDD:276805
PHD_CBP_p300 1280..1311 CDD:277032
HAT_KAT11 1342..1649 CDD:285432
Interaction with histone. /evidence=ECO:0000250|UniProtKB:Q09472 1433..1435
Acetyl-CoA binding. /evidence=ECO:0000250|UniProtKB:Q09472 1434..1436
Acetyl-CoA binding. /evidence=ECO:0000250|UniProtKB:Q09472 1446..1447
Interaction with TRERF1. /evidence=ECO:0000269|PubMed:11349124 1460..1891
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1556..1615
ZZ_CBP 1705..1745 CDD:239077
ZnF_TAZ 1766..1844 CDD:214717
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1874..1959
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1977..2028
Med15 1986..>2413 CDD:255446
Creb_binding 2034..2111 CDD:286163
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2112..2263
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2294..2433
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5076
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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