DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gcn5 and Crebbp

DIOPT Version :9

Sequence 1:	NP_648586.2	Gene:	Gcn5 / 39431	FlyBaseID:	FBgn0020388	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	XP_006521814.1	Gene:	Crebbp / 12914	MGIID:	1098280	Length:	2451	Species:	Mus musculus

Alignment Length:	179	Identity:	45/179 - (25%)
Similarity:	85/179 - (47%)	Gaps:	15/179 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   639 IRSQSEILKEL-IAQRHNEVQKVRPGLTCFKEGLPVIPVESIPGLREIGWKPQNRPARSSRPLEE 702
            ::..|::.:|. ..::.:|..:|       :|..|.:.||:............::....|:|.::
Mouse  1027 LQGSSQVKEETDTTEQKSEPMEV-------EEKKPEVKVEAKEEEENSSNDTASQSTSPSQPRKK 1084

  Fly   703 STDPEKLATSFASVLQSV-RQHTTAWPFLRPV--TAAEVPDYYDHIKYPMDLKTMGERLKKGYYQ 764
            ...||:|..:....|::: ||...:.||.:||  ....:|||:|.:|.||||.|:..:|..|.||
Mouse  1085 IFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQ 1149

  Fly   765 TRRLFMADMARIFSNCRFYNSPDTEYYRCANSLERYFQTK----MRELG 809
            ....::.|:..:|:|...||...:..|:..:.|...|:.:    |:.||
Mouse  1150 EPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLG 1198

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gcn5	NP_648586.2	PCAF_N	73..322	CDD:283997
		COG5076	451..807	CDD:227408	43/175 (25%)
		Acetyltransf_1	526..598	CDD:278980
		Bromo_gcn5_like	708..808	CDD:99941	31/106 (29%)
Crebbp	XP_006521814.1	zf-TAZ	362..429	CDD:366931
		KIX	586..666	CDD:366953
		PHA03247	<687..1037	CDD:223021	1/9 (11%)
		COG5076	942..>1194	CDD:227408	42/173 (24%)
		Bromo_cbp_like	1088..1195	CDD:99927	32/106 (30%)
		RING_CBP-p300	1207..1289	CDD:276805
		PHD_CBP_p300	1291..1322	CDD:277032
		HAT_KAT11	1353..>1564	CDD:369758
		ZZ_CBP	1716..1756	CDD:239077
		ZnF_TAZ	1777..1855	CDD:214717
		Med15	1971..>2422	CDD:312941
		Creb_binding	2045..2125	CDD:370251
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900