DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gcn5 and baz2b

DIOPT Version :9

Sequence 1:	NP_648586.2	Gene:	Gcn5 / 39431	FlyBaseID:	FBgn0020388	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	XP_012826514.1	Gene:	baz2b / 100151715	XenbaseID:	XB-GENE-964622	Length:	2186	Species:	Xenopus tropicalis

Alignment Length:	924	Identity:	176/924 - (19%)
Similarity:	306/924 - (33%)	Gaps:	299/924 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 GAASGAGSVPAEGTRQNSLQRIQQRKQKVFNLPVPQKLAKLSMYSA---CQSEGCRCTGWKTPQE 114
            |..||.|  |.|..::      ::||:...|:.:.:::  |..|..   |.|.|.|        |
Frog  1390 GMESGEG--PEEMAKE------RERKRAAENIQIKEEM--LESYEEKVNCLSSGNR--------E 1436

  Fly   115 NRHRDVESSYC-------------------PE------------------FNEECRNTSCRHSLR 142
            .:.:|..:.:.                   ||                  :...||.|.  ::|:
Frog  1437 QKDKDSTNLFLQKPGSFSKLSKLLEVAKMPPEMDVLTQKANASPNGCSLAYKNNCRGTP--NNLQ 1499

  Fly   143 SHIAH--LDNISSSSM------------------NELLGAIIDMENLFMS-MQRVEDEDTKKVY- 185
            ...:|  .:...|||:                  .:||..:.|....:.| :.|...:||...|
Frog  1500 PSTSHGNTEKPDSSSITPPVSGSGKFYNSPVIPNEQLLKTLTDKNRQWFSLLPRAPCDDTSLTYL 1564

  Fly   186 --QYLFRLLRQCVLTRQ-----------QAVIRGPLGDPPFE-TPCITKAVLSLVFYKYNHLSTP 236
              ........||.|..|           |:.::..||..||. :|...|..:.|:..::....:|
Frog  1565 ESSPAVTTAAQCRLPSQPPSPVPSPVSSQSPVQNTLGINPFTLSPLQMKPGVHLMGLQFCGWPSP 1629

  Fly   237 ----ELQTMTEVAKTFL--NFLNHYNF----ESPSTRRGDLTHEDASNYKINYTRWLVFCHVPAF 291
                .|...|.|....|  :..|.::|    ..||.....:...|.|           .|..|:.
Frog  1630 VLPANLPFSTPVPGMGLTPSDGNSHSFLTPASQPSKSESPIPQSDKS-----------ICTPPSA 1683

  Fly   292 CNSLRQCE--------TSLVFG----------RTLLRTVF------QCMSQQLKK-------KCI 325
            ....:|.:        ..:.||          ::||:.:.      :.:.:|::|       .|:
Frog  1684 VEVPKQVDFPTPRPIPEEMQFGWWRVTDPEDLKSLLKVLHLRGIREKSLQKQIQKHLEYITQTCM 1748

  Fly   326 SERDRFPEDKRSIITLM----PKFLETLRAELLKDDSPIWDTSYRPSNSFVIQQRKRNQEVANVP 386
            ..:|         :|::    |:     ..:|.:|....|.          ::.::...:||.:
Frog  1749 KTKD---------VTIIEMNGPE-----ECQLTRDIVENWS----------VEDQEMEVDVAIL- 1788

  Fly   387 IGPSAASIGGNKRTSVGEPLHKRIKKEPTDRPSSENLDDLPADVVMRAMKSVSESKTTNKAEILF 451
                 ..|...:|..|...|  ::|......|:||.     .|:|....||||:....:..|
Frog  1789 -----QQIEDIERRVVSASL--QVKGWMCPEPASER-----EDLVYYEHKSVSKRHKEHGGE--- 1838

  Fly   452 PVNVSRDENVKAEEQKRAIEFHVVGNSLTKPVDKQTVLWLLGLQLVFAYQLPEMPREYISQLVFD 516
               .:.||...|.|:|.           ..|:|            :...:|.::.|....:.:..
Frog  1839 ---RTTDEGSNAIERKS-----------DNPLD------------IAVTRLTDLERNIERRYLKS 1877

  Fly   517 TKHKTLALIKENQPIGGICFRPFPSQGFTEIVFCAVTMSEQVKGYGTHLMNHLKDYSIQRGIK-- 579
            ....|:.:..:|  :|.:.. |.|:.            |....|.||       :..|..|:|
Frog  1878 PLSTTIQIKLDN--VGTVTV-PAPAP------------SINGDGDGT-------EDDIAPGLKVW 1920

  Fly   580 -HLLTFADCDAIGYFKKQGFSKDI---KLARPVYAGYIKEYDSATLM----------HCELHPSI 630
             ..|:.|...|......|...|.|   |....||....::.|:..|:          |...|...
Frog  1921 RRALSEARSAAQVSLCIQQLQKSIAWEKSIMKVYCQICRKGDNEELLLLCDGCDKGCHTYCHRPK 1985

  Fly   631 VNT-----QF--IAVIRSQSEILK----ELIAQRHNEVQKVR--PGLTCFKEGLPVIPVESIPGL 682
            :.|     .|  ..:.::....||    .|..::..|::|.:  ||.|..::.      ...||
Frog  1986 ITTIPEGDWFCPACIAKASGHNLKMKKSNLKGKKSAELKKGKKSPGDTGEEQS------AGTPG- 2043

  Fly   683 REIGWKPQNRPARSSRPLEESTDPEKLATSFAS------------------VLQSVRQHTTAWPF 729
                 |..::.::..:..|.|..|.|..:|.:|                  :|..:..|..||||
Frog  2044 -----KKGSKDSKKRKGDENSLSPSKQESSPSSKKARSAKEELKDLSLCSVILSEMESHEDAWPF 2103

  Fly   730 LRPVTAAEVPDYYDHIKYPMDLKTMGERLKKGYYQTRRLFMADMARIFSNCRFYNSPDTEYYRCA 794
            |.||....||.|...||.|||..|:.::|..|.|.:...|..|:..:|:||..:|..::|..|..
Frog  2104 LLPVNLKLVPGYKKVIKKPMDFATIRDKLSNGQYPSFEAFALDVRLVFNNCETFNEDESEIGRAG 2168

  Fly   795 NSLERYFQTKMREL 808
            :.:..:|:.:..||
Frog  2169 HKMRVHFEKRWTEL 2182

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gcn5	NP_648586.2	PCAF_N	73..322	CDD:283997	60/358 (17%)
		COG5076	451..807	CDD:227408	83/402 (21%)
		Acetyltransf_1	526..598	CDD:278980	15/74 (20%)
		Bromo_gcn5_like	708..808	CDD:99941	33/117 (28%)
baz2b	XP_012826514.1	HAT_MBD	727..799	CDD:238691
		CCDC66	851..1006	CDD:291889
		GBP_C	<868..987	CDD:303769
		DUF4200	964..1055	CDD:290574
		coiled coil	978..987	CDD:293879
		DDT	1083..1145	CDD:214726
		WHIM3	1706..1744	CDD:292248	4/37 (11%)
		PHD_BAZ2B	1953..2001	CDD:277100	8/47 (17%)
		BAH	1976..>2032	CDD:295389	10/55 (18%)
		Bromo_BAZ2A_B_like	2083..2179	CDD:99935	30/95 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910