DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tral and lsm14b

DIOPT Version :9

Sequence 1:	NP_001261775.1	Gene:	tral / 39430	FlyBaseID:	FBgn0041775	Length:	657	Species:	Drosophila melanogaster
Sequence 2:	XP_031750003.1	Gene:	lsm14b / 595068	XenbaseID:	XB-GENE-5893304	Length:	422	Species:	Xenopus tropicalis

Alignment Length:	609	Identity:	186/609 - (30%)
Similarity:	234/609 - (38%)	Gaps:	219/609 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSGGLPELGSKISLISKADIRYEGRLYTVDPQECTIALSSVRSFGTEDRDTQFQIAPQSQIYDYI 65
            ||.|.|.:||||||||||.|||||.|||:|.:..|:||:.|||||||||.|.....|:.::|:||
Frog     1 MSSGTPYIGSKISLISKAQIRYEGILYTIDTENSTVALAKVRSFGTEDRPTDRPAPPREEVYEYI 65

  Fly    66 LFRGSDIKDIRVVN----NHTLPHHNDPAIMQAQLQNGPPQMPQHFPMPSGMSGPPQQQQVP--- 123
            :|||||||||.|..    :|.||  .||||:|:.|.:.|....|.....|...|.|...|:.
Frog    66 IFRGSDIKDITVCEPPKASHALP--QDPAIVQSSLGSAPSASYQSSVPYSPFRGMPTYSQLAASS 128

  Fly   124 --SQQPPQMPSGGGSGGAGGAGAPGGGGPGYGNGNPFGNLGGPNLANMVGNAGGSLAPGSGAPGS 186
              |||                         |.     .:||...|.:...:||.|.:..|.:|
Frog   129 LLSQQ-------------------------YA-----ASLGLEKLGSPTASAGVSSSCSSPSP-- 161

  Fly   187 GPFMHIGGNQQQPKPQQQKQPISVLDMLAGASRSTTPISLIVSPTAELTQQQQLHQQQNAGQGGN 251
                       ||...:...|.....:...|...:.|  |..||..|...|.
Frog   162 -----------QPVAPEPDIPAEPPQLSPNAGFPSIP--LRKSPMVEQAVQT------------- 200

  Fly   252 GRDAGHKRQNHQQQQNQQHQQRGGPSHNNMQQQQQRGGGSGTDFYNQQRDRRDSGRQMDNNYSN- 315
                                   ||..:..|::.|:..|:..:    ||..|.||.|......|
Frog   201 -----------------------GPLESQAQKKVQQAKGAPVN----QRGIRQSGPQSQPAPLNV 238

  Fly   316 ---------NYNNNNNNQRNRGGGNGMQQQQRGGNGGSGGGGGNGGGNNPAWNMHRGNQNSNNMM 371
                     ..|:.|.....|..||                                       .
Frog   239 PPAAAPVLGTVNDENRRPPRRRSGN---------------------------------------R 264

  Fly   372 NMRNRGMGSRGPMRPNQGYRPQSANNQNKP----RNKIKFEGDFDFEQANNKF--EELRSQLA-K 429
            ..|||   |||               ||:|    .|.||||||||||.||.:|  |||..:.. |
Frog   265 RTRNR---SRG---------------QNRPTTVKENAIKFEGDFDFETANAQFNREELDKEFKDK 311

  Fly   430 LKVAEDGAPKPATNATAATATATNEQVGEKVEGVHTLNGETDKKDDSGNETGAGEHEPEEDDVA- 493
            |...::   ||                 ||         |.::|.|||.||...:..||||.:.
Frog   312 LNFKDE---KP-----------------EK---------EGEEKTDSGVETQNSDGNPEEDPLGP 347

  Fly   494 -VCYDKTKSFFDNISCEAAQDRSKNKKNDWRQERKLNTETFGVSST-RRGSSYRGRNQYYNNNGN 556
             :.||::||||||||.|     .|:::..|.:||||||||||||.. .||.|:|
Frog   348 NIYYDRSKSFFDNISSE-----MKSRRTTWAEERKLNTETFGVSGRFLRGRSFR----------- 396

  Fly   557 GGINSGYGGA-PGYNRNNYRMGGG 579
            ||...|.|.| |..|:...|.|.|
Frog   397 GGFRGGRGSATPRRNQTTQRAGTG 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tral	NP_001261775.1	LSm14_N	4..77	CDD:212483	47/72 (65%)
tral	NP_001261775.1	FDF	406..536	CDD:286601	55/134 (41%)
lsm14b	XP_031750003.1	LSm14_N	4..77	CDD:212483	47/72 (65%)
lsm14b	XP_031750003.1	FDF	285..386	CDD:370547	55/134 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	97	1.000	Domainoid score	I7102
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	216	1.000	Inparanoid score	I3510
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1569369at2759
OrthoFinder	1	1.000	-	-		FOG0001497
OrthoInspector	1	1.000	-	-		otm47529
Panther	1	1.100	-	-	LDO	PTHR13586
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2277
SonicParanoid	1	1.000	-	-		X1222
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.190