DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tral and Lsm14a

DIOPT Version :9

Sequence 1:	NP_001261775.1	Gene:	tral / 39430	FlyBaseID:	FBgn0041775	Length:	657	Species:	Drosophila melanogaster
Sequence 2:	NP_001121024.1	Gene:	Lsm14a / 361554	RGDID:	1305695	Length:	468	Species:	Rattus norvegicus

Alignment Length:	625	Identity:	190/625 - (30%)
Similarity:	247/625 - (39%)	Gaps:	206/625 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSGGLPELGSKISLISKADIRYEGRLYTVDPQECTIALSSVRSFGTEDRDTQFQIAPQSQIYDYI 65
            ||||.|.:||||||||||:|||||.|||:|.:..|:||:.|||||||||.|...|.|:.::::||
  Rat     1 MSGGTPYIGSKISLISKAEIRYEGILYTIDTENSTVALAKVRSFGTEDRPTDRPIPPRDEVFEYI 65

  Fly    66 LFRGSDIKDIRVVN----NHTLPHHNDPAIMQAQLQNGPPQMPQHFPMPSGMSGPPQQQQVPSQQ 126
            :||||||||:.|..    ..:||  .||||:|:.|.:.....     ...|..||..:....||.
  Rat    66 IFRGSDIKDLTVCEPPKPQCSLP--QDPAIVQSSLGSSSSSF-----QSVGSYGPFGRMPAYSQF 123

  Fly   127 PPQMPSGGGSGGAGGAGAPGGGGPGYGNGNPFG----NLGGPNLANMVGNA--------GGSLAP 179
            .|....|...|..|.||:         :...||    |.|..:.:|.||:|        ...||.
  Rat   124 SPSTLVGQQFGAVGVAGS---------SLTSFGTEASNSGTLSQSNAVGSAFTQDTRSVKPQLAQ 179

  Fly   180 GSGAPGSGPFMHIGGNQQQPKPQQQKQPISV-LDMLAGASRSTTPISLIVSPTAELTQQQQLHQQ 243
            |..:|...|.      ::.|..:|..|..|. |...|...|.:...:..:.||::.....|.|::
  Rat   180 GRSSPQLDPL------RKSPTMEQAVQTASAHLPAPAPVGRRSPVPARPLPPTSQKAIDNQEHRR 238

  Fly   244 QNAGQGGNGRDAGHK--RQNHQQQQNQQHQQRGGPSHNNMQQQQQRGGGSGTDFYNQQRDRRDSG 306
            ...          ||  |..::|.:|                                    ||.
  Rat   239 AEV----------HKVPRPENEQLRN------------------------------------DSK 257

  Fly   307 RQMDNNYSNNYNNNNNNQRNRGGGNGMQQQQRGGNGGSGGGGGNGGGNNPAWNMHRGNQNSNNMM 371
            ||:                    ..|:....|.|.||..||.|
  Rat   258 RQV--------------------VPGVPSAPRRGRGGHRGGRG---------------------- 280

  Fly   372 NMRNRGMGSRGPMRPNQGYRPQSANNQNKPRNKIKFEGDFDFEQANNKF--EEL-RSQLAKLKVA 433
               ..|:...|||                     |||.|||||.||.:|  ||: |....|||:.
  Rat   281 ---RFGIRRDGPM---------------------KFEKDFDFESANAQFNKEEIDREFHNKLKLK 321

  Fly   434 EDGAPKPATNATAATATATNEQVGEKVEGVHTLNGETDKKDDSGNETGAGEHEPEEDDVA---VC 495
            ||...|.                 ||     .:|||  .|.|||.:|...|...:|:|..   ..
  Rat   322 EDKLEKQ-----------------EK-----PVNGE--DKGDSGVDTQNSEGNADEEDPLGPNCY 362

  Fly   496 YDKTKSFFDNISCEAAQDRSKNKKNDWRQERKLNTETFGVSSTRRGSSYRGRNQYYNNNGNGGIN 560
            |||||||||||||    |.::.::..|.:||:||.||||:.....    |||..|   .|.||:
  Rat   363 YDKTKSFFDNISC----DDNRERRPTWAEERRLNAETFGIPLRPN----RGRGGY---RGRGGL- 415

  Fly   561 SGYGGAPGYNRNNYRMGGGGGNFRN----RSNNRNNGGGR 596
             |:.|..|      |..|.||.|..    |:..|...|||
  Rat   416 -GFRGGRG------RGSGRGGTFTAPRGFRAGFRGARGGR 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tral	NP_001261775.1	LSm14_N	4..77	CDD:212483	46/72 (64%)
tral	NP_001261775.1	FDF	406..536	CDD:286601	56/135 (41%)
Lsm14a	NP_001121024.1	LSm14_N	4..77	CDD:212483	46/72 (64%)
Lsm14a	NP_001121024.1	FDF	291..399	CDD:286601	56/135 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347722
Domainoid	1	1.000	97	1.000	Domainoid score	I7076
eggNOG	1	0.900	-	-		E1_KOG1073
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1569369at2759
OrthoFinder	1	1.000	-	-		FOG0001497
OrthoInspector	1	1.000	-	-		otm44489
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13586
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1222
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.900