DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sti and CDC42BPB

DIOPT Version :9

Sequence 1:NP_001261768.1 Gene:sti / 39429 FlyBaseID:FBgn0002466 Length:1858 Species:Drosophila melanogaster
Sequence 2:XP_005268284.1 Gene:CDC42BPB / 9578 HGNCID:1738 Length:1728 Species:Homo sapiens


Alignment Length:2025 Identity:481/2025 - (23%)
Similarity:769/2025 - (37%) Gaps:685/2025 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    60 AICREGLLDAFCLLYNECDKDTLKKRDRNIAEFVNKFRPIIEETRKLRVNADDFLIKTLIGQGYF 124
            |:..|.|||....||.||....| :||:.:|||:...:|..:..::::::.:||.|..:||:|.|
Human    24 ALSVETLLDVLVCLYTECSHSAL-RRDKYVAEFLEWAKPFTQLVKEMQLHREDFEIIKVIGRGAF 87

  Fly   125 GNVHLVVERQTNDIYAMKKIKK----SVVTTSQVKEERDIMSIRNSEWLINLQYAFQDNDNLYLV 185
            |.|.:|..:.|..|||||.:.|    ....|:..:||||::...:.:|:..|.|||||.::||||
Human    88 GEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQWITALHYAFQDENHLYLV 152

  Fly   186 MEYMPGGDLLSLMSR-HGPFDEDLARFYLAELTVALHTLHEMGYVHRDIKPENILIDRFGHIKLA 249
            |:|..|||||:|:|: .....||:||||:.|:.:|:.::|::.||||||||:|:|:|..|||:||
Human   153 MDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLA 217

  Fly   250 DFGNAAALDRDGHVLSLSPVGTPDYIAPELLQTISTYKLSKSMHD-VSRI-VSCDYWSMGIIGYE 312
            |||:...::.||.|.|...|||||||:||:||         :|.| :.:. ..||:||:|:..||
Human   218 DFGSCLKMNDDGTVQSSVAVGTPDYISPEILQ---------AMEDGMGKYGPECDWWSLGVCMYE 273

  Fly   313 LICETTPFHEDNVHETYSKILSHCEESHLKELISFPADL-KVSVNYRNLIESLVTNPSKRL---S 373
            ::...|||:.:::.|||.||::|      :|...||:.: .||...::||:.|:.:..:||   .
Human   274 MLYGETPFYAESLVETYGKIMNH------EERFQFPSHVTDVSEEAKDLIQRLICSRERRLGQNG 332

  Fly   374 YERIKNHPFFSEIPWGSIRSQVPPIIPTVRSDDDTSNF---EDGIRHKTRREQGVAKKSLTTNMK 435
            .|..|.|.||..:.|.:||:...|.||.|.|..|||||   :|.:|:......|          .
Human   333 IEDFKKHAFFEGLNWENIRNLEAPYIPDVSSPSDTSNFDVDDDVLRNTEILPPG----------S 387

  Fly   436 SNDFSGKDLPFIGYSFVHME--------KSAISATT---DEKLQEKLKELLQKLKTRENEISMLK 489
            ...|||..|||||::|....        ||.:.:.|   ||.:|..|:..|| ::..|..|..|:
Human   388 HTGFSGLHLPFIGFTFTTESCFSDRGSLKSIMQSNTLTKDEDVQRDLEHSLQ-MEAYERRIRRLE 451

  Fly   490 QDLLRAQQSLRKTDNKSQVVADAKMEIKKLQQIIKEKTMELTTCKTQIKTLQSSAKIDEEMWSKK 554
            |:.|...   ||....:|.|.......:.|....::|         :||      |::||:...|
Human   452 QEKLELS---RKLQESTQTVQSLHGSSRALSNSNRDK---------EIK------KLNEEIERLK 498

  Fly   555 EATITDLLRLNRQKYEEAKIASEQRYEKQLADK---KQELASTLQKLDARELEFNAKFEECKHLS 616
            .                 |||...|.|:||.|.   :||...:.|:|  |.|             
Human   499 N-----------------KIADSNRLERQLEDTVALRQEREDSTQRL--RGL------------- 531

  Fly   617 MKLQNYKDMLQQIKEQNLKSETNHEEQRRQMAELYEQKLTDLRKKVRDSQDTNRRMTMEIKEIRT 681
                                |..|...|::..||::|.:           :.:.|:..:.||:: 
Human   532 --------------------EKQHRVVRQEKEELHKQLV-----------EASERLKSQAKELK- 564

  Fly   682 ELDESISSSKSTQEAKNATERNIEEILRRLNEEIASNNELHAEKVKLETKLQLKENETQEVRAEC 746
                     .:.|:.|.|.:...|     |||.:|   ||.|:|.|:..:|:.||.|.:      
Human   565 ---------DAHQQRKLALQEFSE-----LNERMA---ELRAQKQKVSRQLRDKEEEME------ 606

  Fly   747 HRLERELQLAECRCQLAESSLATQVSPYETAPGSLTELNAIEDQLRADLLAAKESENHQKGRADQ 811
                                :|||            :::|:..::|               ||::
Human   607 --------------------VATQ------------KVDAMRQEMR---------------RAEK 624

  Fly   812 LQTLVTKLEQMLERFNEQSLSPTKSHSSRKQEGETVGDMLERQNEKLEDKLAAVREQMIVERQAA 876
            |                           ||:                                  
Human   625 L---------------------------RKE---------------------------------- 628

  Fly   877 RTANLSLWKVEKQLEEALSEKKLLARRMELTEDRIKKVQNASDEAQRMLKTSQEETRQRESRIEE 941
                     :|.||::|::|                    ||.| :::.:.|:...:|.||.:|.
Human   629 ---------LEAQLDDAVAE--------------------ASKE-RKLREHSENFCKQMESELEA 663

  Fly   942 LKQELAAAKRDVLKEHRQWEKAEQERMKCKSEIIEHLANVHRLEQQETELRQKLRQIQSRFDGVT 1006
            ||.:..........||      :||..|.|||:.:.:     |..:|..:|::...:        
Human   664 LKVKQGGRGAGATLEH------QQEISKIKSELEKKV-----LFYEEELVRREASHV-------- 709

  Fly  1007 LEQKNTIRELQEEREKSRKANDSCLVLQKELKQLTDNFQRLKYACSITDSQLTEVETMLKSEQER 1071
            ||.||..:|:.:.....       |.||||:..|.|..:                    ||::||
Human   710 LEVKNVKKEVHDSESHQ-------LALQKEILMLKDKLE--------------------KSKRER 747

  Fly  1072 NKSQKSQLDTLHEKLRERNDQLTDLRKQLTTVESEKRLAEQRAQVLASEIDELRLNLKEQQKKLV 1136
            :...:..:.|:.:|.......|.|..|:| |.|:||         |.|.:|           ||.
Human   748 HNEMEEAVGTIKDKYERERAMLFDENKKL-TAENEK---------LCSFVD-----------KLT 791

  Fly  1137 AQQDQLVEQTNALFATQERAELLDGQNANYEAQTADSNREMVSLKEENARILSELFHKKEEVGNL 1201
            ||..||.::...|.|.:|..       |::|||.|:              |:..:..:|:..|.|
Human   792 AQNRQLEDELQDLAAKKESV-------AHWEAQIAE--------------IIQWVSDEKDARGYL 835

  Fly  1202 QA-------EIRGLESAQANLHAEIDSL--------QDTLAEKE-QFYVQRDIKSNATLAQHKKL 1250
            ||       |:..|.|:...... :|.|        .|..|..| |..::.:|::       |:|
Human   836 QALASKMTEELEALRSSSLGSRT-LDPLWKVRRSQKLDMSARLELQSALEAEIRA-------KQL 892

  Fly  1251 IDYLQLKVEDLSAKKKKTLADKLFGSSHTNKENVSPNDVESSILYRALKEE------LKREQKMN 1309
            :.....||:|.:.    ||..||..|...|:|.:.    |..||.:.::|:      ||.....:
Human   893 VQEELRKVKDANL----TLESKLKDSEAKNRELLE----EMEILKKKMEEKFRADTGLKLPDFQD 949

  Fly  1310 SL--------------LKEQLAQLNGTATLRS-PRKSAAVNGDSDAPKQRPVSIAALPRSPQKQQ 1359
            |:              .::.|:..:.::.|.. ...|:|...::.|||  |.:..::..:..:||
Human   950 SIFEYFNTAPLAHDLTFRDSLSSSSASSLLAFWEETSSASEQETQAPK--PEASPSMSVAASEQQ 1012

  Fly  1360 QPLKR---TTSQVELKTT------AEKPTKVTIENQAHHRFELALQESKVDAVNCVVCEKAVVAG 1415
            :.:.|   ..|.|.|.||      ..||..        |:|.:....|.....:|......::..
Human  1013 EDMARPPQRPSAVPLPTTQALALAGPKPKA--------HQFSIKSFSSPTQCSHCTSLMVGLIRQ 1069

  Fly  1416 SPFWKCKECKDVTHRKCRS-------------------NVQSHCGST--------KPT------- 1446
            .  :.|:.|....|..|:.                   :||...|:.        |||       
Human  1070 G--YACEVCSFACHVSCKDGAPQVCPIPPEQSKRPLGVDVQRGIGTAYKGHVKVPKPTGVKKGWQ 1132

  Fly  1447 ---APSAD------DLSSIQS-----VSSLTLDSVDVAGGTTSGGEYIGSLVYSSDGAEDQARKE 1497
               |...|      ||...:|     ::|..||..|        .|:..|.|.:||......|  
Human  1133 RAYAVVCDCKLFLYDLPEGKSTQPGVIASQVLDLRD--------DEFSVSSVLASDVIHATRR-- 1187

  Fly  1498 IEVNCAFEVAEQQI------------------------LLLGCNTGLYAYHLDSQRLVHISGLES 1538
             ::.|.|.|....:                        :|.|..:.|:...|.:| :||:. ||:
Human  1188 -DIPCIFRVTASLLGAPSKTSSLLILTENENEKRKWVGILEGLQSILHKNRLRNQ-VVHVP-LEA 1249

  Fly  1539 V-SCMSICKRLAKAIMVG----TVG--EKLYQCDY-RQLESRCQSSSSCHKPVLETSAIELPFAN 1595
            . |.:.:.|.:..|.:|.    .||  |.||..:. |.:..|.......|:       |||    
Human  1250 YDSSLPLIKAILTAAIVDADRIAVGLEEGLYVIEVTRDVIVRAADCKKVHQ-------IEL---- 1303

  Fly  1596 RTPSEKWKLVLIS-------------DEAENALD-------SVAIAATSTRIVILKYDLKLHMFK 1640
             .|.||..::|..             |.||.:.|       ...:.||:|    ||.:....:|.
Human  1304 -APREKIVILLCGRNHHVHLYPWSSLDGAEGSFDIKLPETKGCQLMATAT----LKRNSGTCLFV 1363

  Fly  1641 PVRALDTATPV--TSIFFTRHSAIVS----------SDKF-----------------YEIDLDNY 1676
            .|:.|.....:  |..|..:.:.||:          .|:.                 ..::|.|.
Human  1364 AVKRLILCYEIQRTKPFHRKFNEIVAPGSVQCLAVLRDRLCVGYPSGFCLLSIQGDGQPLNLVNP 1428

  Fly  1677 AAEEFVDLSDKSMESTAKCQPLTAVRISRQEYLLCFAEYGVFVDEFGCRSRPYDLNWVYAPTG-- 1739
            .......||.:|.::      |.||.:..:||||||:..|::||..|.|:|..:|.|..||..  
Human  1429 NDPSLAFLSQQSFDA------LCAVELESEEYLLCFSHMGLYVDPQGRRARAQELMWPAAPVACS 1487

  Fly  1740 ------FVYRD---PFLFISHYQSVQIVRLHR-------------------------SFSKEMAS 1770
                  .||.:   ....:...:.||.:.|.|                         .||..:.:
Human  1488 CSPTHVTVYSEYGVDVFDVRTMEWVQTIGLRRIRPLNSEGTLNLLNCEPPRLIYFKSKFSGAVLN 1552

  Fly  1771 GDNASENSES---------------PELQRVYL-------PHYMSTLLANSGDVNLYAVAIDQRP 1813
            ..:.|:||:.               ||.:|:..       |...|.:::|..:.|..|   ...|
Human  1553 VPDTSDNSKKQMLRTRSKRRFVFKVPEEERLQQRREMLRDPELRSKMISNPTNFNHVA---HMGP 1614

  Fly  1814 CNGTQKIYHL 1823
            .:|.|.:..|
Human  1615 GDGMQVLMDL 1624

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
stiNP_001261768.1 PKc_like 111..452 CDD:304357 142/354 (40%)
S_TKc 113..383 CDD:214567 115/280 (41%)
Smc 487..1222 CDD:224117 144/744 (19%)
CNH 1503..1774 CDD:279162 79/387 (20%)
CDC42BPBXP_005268284.1 STKc_MRCK_beta 3..411 CDD:270774 159/412 (39%)
S_TKc 76..342 CDD:214567 115/280 (41%)
TPH 426..786 CDD:290579 126/659 (19%)
KELK 528..606 CDD:292424 29/141 (21%)
DMPK_coil 878..939 CDD:117396 19/75 (25%)
C1 1043..1092 CDD:237996 8/50 (16%)
PH_MRCK 1102..1236 CDD:269949 27/144 (19%)
CNH 1262..1527 CDD:279162 64/286 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0612
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D759391at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR22988
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.920

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