DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sti and USO1

DIOPT Version :9

Sequence 1:	NP_001261768.1	Gene:	sti / 39429	FlyBaseID:	FBgn0002466	Length:	1858	Species:	Drosophila melanogaster
Sequence 2:	NP_001276978.1	Gene:	USO1 / 8615	HGNCID:	30904	Length:	973	Species:	Homo sapiens

Alignment Length:	953	Identity:	174/953 - (18%)
Similarity:	353/953 - (37%)	Gaps:	283/953 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   506 SQVVADAKMEIKKLQQIIKEKTME--LTTCKTQIKTLQSSAKIDEEMWSKKEATITDLLRLNRQK 568
            |.::.|.:..::.|:.:.|:..:|  :...:..|..||:. :.|.|:......|:.::  ::.::
Human    33 STLLDDRRNAVRALKSLSKKYRLEVGIQAMEHLIHVLQTD-RSDSEIIGYALDTLYNI--ISNEE 94

  Fly   569 YEEAKIASEQRYEKQLAD----------KKQELASTLQKLDARELEFNAKFEECKHLSMKLQNYK 623
            .||.....|:...:|..|          |:||..:.|..| ..|.:|:.::...|.|:..|:...
Human    95 EEEVDDVEEENSTRQSEDLGSQFTEIFIKQQENVTLLLSL-LEEFDFHVRWPGVKLLTSLLKQLG 158

  Fly   624 DMLQQIKEQNLKSETNHEEQRRQMAELYEQKLTDLRKKVRDSQDTNRRMTMEIKEIRTE---LDE 685
            ..:|||               ..::.:...:|.||   :.||::.          ||.:   |.:
Human   159 PQVQQI---------------ILVSPMGVSRLMDL---LADSREV----------IRNDGVLLLQ 195

  Fly   686 SISSSKSTQEAKNATERNIEEILRRLNEEIASNNELHAEKVKLETKLQLKENETQ---------- 740
            :::.|....:...|.|...|.:|..::||..|:..:..|...:..:..||.|.:.
Human   196 ALTRSNGAIQKIVAFENAFERLLDIISEEGNSDGGIVVEDCLILLQNLLKNNNSNQNFFKEGSYI 260

  Fly   741 -------EVRAE--------CHRLERELQL------------AECRCQLA--ESSLATQVSPYET 776
                   ||..|        ...|...|||            |...||.|  :..|..|:.....
Human   261 QRMKPWFEVGDENSGWSAQKVTNLHLMLQLVRVLVSPTNPPGATSSCQKAMFQCGLLQQLCTILM 325

  Fly   777 APG----SLTE-LNAIED-----QLRADLLAAKESEN---------------------------- 803
            |.|    .||| :|.:.:     |:..|..|:..:.:
Human   326 ATGVPADILTETINTVSEVIRGCQVNQDYFASVNAPSNPPRPAIVVLLMSMVNERQPFVLRCAVL 390

  Fly   804 ---------HQKGRADQLQTLV----------TKLEQML--ERFNEQSLS----------PTKSH 837
                     :|||:.:.:.||:          ....|:|  ..|:..|||          ..:.:
Human   391 YCFQCFLYKNQKGQGEIVSTLLPSTIDATGNSVSAGQLLCGGLFSTDSLSNWCAAVALAHALQEN 455

  Fly   838 SSRKQEGETV-----------------------GDMLERQNEKLEDKLAAV-------------- 865
            :::|::...|                       ||.::|:..|::.::..:
Human   456 ATQKEQLLRVQLATSIGNPPVSLLQQCTNILSQGDKIDRRGSKIQTRVGLLMLLCTWLSNCPIAV 520

  Fly   866 ----------------------REQMIVERQAARTANLSLWKVEKQLEEALSE--KKLLARRMEL 906
                                  .|:.:|:...|....:|::..:..||..:.|  |:|:.:|:.
Human   521 THFLHNSANVPFLTGQIAENLGEEEQLVQGLCALLLGISIYFNDNSLESYMKEKLKQLIEKRIG- 584

  Fly   907 TEDRIKKV---------QNASDEAQ----------------------------RMLKTSQEETRQ 934
            .|:.|:|:         ..||.:.|                            .:.|:|:|:.::
Human   585 KENFIEKLGFISKHELYSRASQKPQPNFPSPEYMIFDHEFTKLVKELEGVITKAIYKSSEEDKKE 649

  Fly   935 RESR--IEELKQELAAAKRDVLKEHRQWEKAEQE--RMKCKSEIIEHLANVHRLEQQETELRQKL 995
            .|.:  :|:....:...|..:.::..|.|:..|:  .:||::            ||.:|.:.|::
Human   650 EEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKCQN------------EQLQTAVTQQV 702

  Fly   996 RQIQSRFDGVTLEQKNTIRELQEEREKSRKANDSCLVLQKELKQLTDNFQRLKYACSITDSQLTE 1060
            .|||...|...|.:....::.|.:...|..|..:. :..:|:.:|.:..:.||....:..|||||
Human   703 SQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNG-IQPEEIGRLREEIEELKRNQELLQSQLTE 766

  Fly  1061 VETMLKSEQERNKSQKSQLDTLHEKLRERNDQLTDLRKQLTTVESEKRLAEQRAQV--LASEIDE 1123
            .::|:::.:....|..::..:.....|: ::|:.:|:::|.|::|:  |..|..::  |.:|..|
Human   767 KDSMIENMKSSQTSGTNEQSSAIVSARD-SEQVAELKQELATLKSQ--LNSQSVEITKLQTEKQE 828

  Fly  1124 LRLNLKEQQKKLVAQQDQLVEQTNALFATQERAELLDGQNANYEAQTADSNREMVSLKEENARIL 1188
            |.     |:.:..|:..::..:|..:.||  :...::|:.:....:|.:...|:.:|.||...|.
Human   829 LL-----QKTEAFAKSVEVQGETETIIAT--KTTDVEGRLSALLQETKELKNEIKALSEERTAIK 886

  Fly  1189 SELFHKKEEVGNLQAEIRGLESAQANLHAEIDSLQDTLAEKEQ 1231
            .:|......:..||.|...||....:...|.|.|...||:::|
Human   887 EQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLADQDQ 929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sti	NP_001261768.1	PKc_like	111..452	CDD:304357
		S_TKc	113..383	CDD:214567
		Smc	487..1222	CDD:224117	170/942 (18%)
		CNH	1503..1774	CDD:279162
USO1	NP_001276978.1	ARM	19..>92	CDD:237987	11/61 (18%)
		Uso1_p115_head	351..639	CDD:282693	35/288 (12%)
		Lebercilin	672..876	CDD:292252	48/226 (21%)
		DUF342	<746..877	CDD:302792	30/140 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	774..794		1/19 (5%)
		Uso1_p115_C	837..947	CDD:282695	23/95 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	937..973
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910