DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sti and CDC42BPA

DIOPT Version :9

Sequence 1:NP_001261768.1 Gene:sti / 39429 FlyBaseID:FBgn0002466 Length:1858 Species:Drosophila melanogaster
Sequence 2:NP_001374479.1 Gene:CDC42BPA / 8476 HGNCID:1737 Length:1845 Species:Homo sapiens


Alignment Length:2056 Identity:456/2056 - (22%)
Similarity:801/2056 - (38%) Gaps:610/2056 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    40 PASTRRSIVPVSTTSAAVAEAICREGLLDAFCLLYNECDKDTLKKRDRNIAEFVNKFRPIIEETR 104
            ||.|......|.|             |||....||:||:...| :|::||.|::...:|...:.:
Human    18 PAQTNGQCFSVET-------------LLDILICLYDECNNSPL-RREKNILEYLEWAKPFTSKVK 68

  Fly   105 KLRVNADDFLIKTLIGQGYFGNVHLVVERQTNDIYAMKKIKK----SVVTTSQVKEERDIMSIRN 165
            ::|::.:||.|..:||:|.||.|.:|..:..:.::|||.:.|    ....|:..:||||::...:
Human    69 QMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGD 133

  Fly   166 SEWLINLQYAFQDNDNLYLVMEYMPGGDLLSLMSR-HGPFDEDLARFYLAELTVALHTLHEMGYV 229
            ::|:..|.|||||::||||||:|..|||||:|:|: .....||:|||||||:.:|:.::|::.||
Human   134 NKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVIAIDSVHQLHYV 198

  Fly   230 HRDIKPENILIDRFGHIKLADFGNAAALDRDGHVLSLSPVGTPDYIAPELLQTISTYKLSKSMHD 294
            ||||||:|||:|..|||:|||||:...|..||.|.|...|||||||:||:||.:..   .|..:.
Human   199 HRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMED---GKGRYG 260

  Fly   295 VSRIVSCDYWSMGIIGYELICETTPFHEDNVHETYSKILSHCEESHLKELISFPADL-KVSVNYR 358
                ..||:||:|:..||::...|||:.:::.|||.||::|      ||...|||.: .||.|.:
Human   261 ----PECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNH------KERFQFPAQVTDVSENAK 315

  Fly   359 NLIESLVTNPSKRL---SYERIKNHPFFSEIPWGSIRSQVPPIIPTVRSDDDTSNFEDGIRHKTR 420
            :||..|:.:...||   ..|..|.|||||.|.|.:||:...|.||.|.|..|||||:        
Human   316 DLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIPEVSSPTDTSNFD-------- 372

  Fly   421 REQGVAKKSLTTNMKSND-FSGKDLPFIGYSFVHMEKSAISATTDEKLQEKLKELLQKLKTRENE 484
            .:....|.|.|....::. |||..|||:|:::.                                
Human   373 VDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYT-------------------------------- 405

  Fly   485 ISMLKQDLLRAQQSLRKTDNKSQVVADAKMEIKKLQQIIKEKTMELTTCKTQIKTLQSSAKIDEE 549
                ...:|..:..||.|...:.:..|..::                      :||.::  :..|
Human   406 ----SSCVLSDRSCLRVTAGPTSLDLDVNVQ----------------------RTLDNN--LATE 442

  Fly   550 MWSKKEATITDLLRLNRQKYEEAKIASEQRYEKQLADKKQELASTLQKLDARELEFNAKFEECKH 614
            .:.::      :.||.::|.|             |:.|.||...|:|.|....::  ......|.
Human   443 AYERR------IKRLEQEKLE-------------LSRKLQESTQTVQALQYSTVD--GPLTASKD 486

  Fly   615 LSMKLQNYKDMLQQIKEQNLKSETNHEEQRRQMAELYEQKLTDLRKKVRDSQDTNRRMTMEIKEI 679
            |.:|  |.|:.::::::|  .:|::|.||:.:.|....|:|.|..::::..:...:.:..|.:::
Human   487 LEIK--NLKEEIEKLRKQ--VTESSHLEQQLEEANAVRQELDDAFRQIKAYEKQIKTLQQEREDL 547

  Fly   680 RTELDESI----SSSKSTQEAKNATERNIEEILRRLNEEIASNNELHAEKVKLETKLQLKENETQ 740
            ..||.::.    :.||..::|....:..::|.: .:||.:   .|||.:|.||...::.||.|..
Human   548 NKELVQASERLKNQSKELKDAHCQRKLAMQEFM-EINERL---TELHTQKQKLARHVRDKEEEVD 608

  Fly   741 EVRAECHRLERELQLAECRCQLAESSLATQVSPYETAPGSLTELNAIEDQLRADLLAAKESENHQ 805
            .|..:...|.:||:    |.:.|:..|...           ||  |:..:...|....::||::.
Human   609 LVMQKVESLRQELR----RTERAKKELEVH-----------TE--ALAAEASKDRKLREQSEHYS 656

  Fly   806 KGRADQLQTLVTKLEQMLERFNEQSLSPTKSHSSRKQEGETVGDMLERQNEKLEDKLAAVREQMI 870
            |...::|:.|..|         :.|.||.......:||...:...||:::...|::|:. ||.: 
Human   657 KQLENELEGLKQK---------QISYSPGVCSIEHQQEITKLKTDLEKKSIFYEEELSK-REGI- 710

  Fly   871 VERQAARTANLSLWKVEKQLEEALSEKKLLARRMELTEDRIKKVQNASDEAQRMLKTSQEETRQR 935
               .|....||     :|:|.::..::..|.:.:.:.:|:::             ||.:|...:|
Human   711 ---HANEIKNL-----KKELHDSEGQQLALNKEIMILKDKLE-------------KTRRESQSER 754

  Fly   936 ESRIEELKQELAAAKRDVLKEHRQWEKAEQERMKCKSEIIEHLANVHRLEQQETELRQKLRQIQS 1000
            |....|.||:                                      .|:::..|.::.:::.|
Human   755 EEFESEFKQQ--------------------------------------YEREKVLLTEENKKLTS 781

  Fly  1001 RFDGVTLEQKNTIRELQEEREKSRKANDSCLVLQKELKQLTDNFQRLKYACSITDSQLTEVETML 1065
            ..|.:|...:|.....|:              |::|:|.|.|.    |.:.:..::|:||:...:
Human   782 ELDKLTTLYENLSIHNQQ--------------LEEEVKDLADK----KESVAHWEAQITEIIQWV 828

  Fly  1066 KSEQERNKSQKSQLDTLHEKLRE-----RNDQL----TDL---RKQLTTVESEKRL-------AE 1111
            ..|    |..:..|..|..|:.|     ||..|    ||:   .::...::...||       ||
Human   829 SDE----KDARGYLQALASKMTEELEALRNSSLGTRATDMPWKMRRFAKLDMSARLELQSALDAE 889

  Fly  1112 QRA-QVLASEIDELRLN-------LKEQQKK---LVAQQDQLVEQTNALFATQERAELLDGQNA- 1164
            .|| |.:..|:::::.:       ||:.:||   |:::.:||::.|..| .:::..|..|.|:: 
Human   890 IRAKQAIQEELNKVKASNIITECKLKDSEKKNLELLSEIEQLIKDTEEL-RSEKGIEHQDSQHSF 953

  Fly  1165 ------------NYEAQTADSNREMVSLKEENARILSELFHKKEEVGNLQAEIRGLESAQANLHA 1217
                        .:|...:.|:..::...::                      |......|:...
Human   954 LAFLNTPTDALDQFEDSFSSSSSSLIDFLDD----------------------RSPSCTPASKGR 996

  Fly  1218 EIDSLQDTLA--EKEQFYVQRDIKSNATL--AQHKKLIDYLQLKVEDLSAKKK----------KT 1268
            ..|.:::|..  ...:|::|....|.:|.  |:..|.:|...|.|...:.:||          |.
Human   997 RTDPVENTYVWNPSVKFHIQSRSTSPSTSSEAEPVKTVDSTPLSVHTPTLRKKGCPGSTGFPPKR 1061

  Fly  1269 LADKLFGSSHTNKENVSPNDVE--SSILYRALKEELKREQKMNSLLKEQLAQLNGTATLRSPRKS 1331
            ...:.|..|.|     :|....  :|::...:::...             .::.|.        |
Human  1062 KTHQFFVKSFT-----TPTKCHQCTSLMVGLIRQGCS-------------CEVCGF--------S 1100

  Fly  1332 AAVNGDSDAPKQRPVSIAALPRSPQKQQQPL-----KRTTSQVELKTTAEKPTKVTIENQAHHR- 1390
            ..:...:.||...||       .|::.:.||     |...:..|......||..|   .:...| 
Human  1101 CHITCVNKAPTTCPV-------PPEQTKGPLGIDPQKGIGTAYEGHVRIPKPAGV---KKGWQRA 1155

  Fly  1391 ------FELAL---QESKVDAVNCVVCE-----------KAVVAGSPFWKCKECKDVTH--RK-- 1431
                  |:|.|   .|.|....:.|:.:           .:|:|          .||.|  ||  
Human  1156 LAIVCDFKLFLYDIAEGKASQPSVVISQVIDMRDEEFSVSSVLA----------SDVIHASRKDI 1210

  Fly  1432 -CRSNVQSHCGSTKPTAPSADDLSSIQSVSSLTLDSVDVAGGTTSGGEYIGSL------------ 1483
             |...|            :|..||:..:..|:.:    :|.......:::|.|            
Human  1211 PCIFRV------------TASQLSASNNKCSILM----LADTENEKNKWVGVLSELHKILKKNKF 1259

  Fly  1484 ----VYSSDGAEDQARKEIEVNCAFEVAEQQILLLGCNTGLYAYHLDSQRLVHISGLESVSCMSI 1544
                ||....|.|.....|:...|..:.:.:.:.||...||:..|:....::.:...:.:..:.:
Human  1260 RDRSVYVPKEAYDSTLPLIKTTQAAAIIDHERIALGNEEGLFVVHVTKDEIIRVGDNKKIHQIEL 1324

  Fly  1545 C--KRLAKAIMVGTVGEKLY--------QCDYRQLESR--CQSSSS-----------CHKPVLET 1586
            .  .:|...|.......:|:        :.|:.:|...  ||:.:|           |.....:.
Human  1325 IPNDQLVAVISGRNRHVRLFPMSALDGRETDFYKLSETKGCQTVTSGKVRHGALTCLCVAMKRQV 1389

  Fly  1587 SAIELPFANRTPSEKWKLVLISDEAENALDSVAIAATSTRIVI------LKYDLKLHMFKPVRAL 1645
            ...|| |.::|...|:|.:.:....:      .:|..|.::.:      |:|.|.          
Human  1390 LCYEL-FQSKTRHRKFKEIQVPYNVQ------WMAIFSEQLCVGFQSGFLRYPLN---------- 1437

  Fly  1646 DTATPVTSIFFTRHSAIVSSDKFYEIDLDNYAAEEFVDLSDKSMESTAKCQPLTAVRISRQEYLL 1710
            ....|.:.:....|:.             ::.|.:.:|         |.|    ||.||.:||||
Human  1438 GEGNPYSMLHSNDHTL-------------SFIAHQPMD---------AIC----AVEISSKEYLL 1476

  Fly  1711 CFAEYGVFVDEFGCRSRPYDLNWVYAPTGFVYRDPFLFISHYQSVQIVRLHRS------------ 1763
            ||...|::.|..|.|||..:|.|...|:...|..|:|.:....:|.|..::..            
Human  1477 CFNSIGIYTDCQGRRSRQQELMWPANPSSCCYNAPYLSVYSENAVDIFDVNSMEWIQTLPLKKVR 1541

  Fly  1764 --------------------FSKEMASGD-----NASENSES----------------PELQRVY 1787
                                |..:||.||     ..|:||..                ||.:|:.
Human  1542 PLNNEGSLNLLGLETIRLIYFKNKMAEGDELVVPETSDNSRKQMVRNINNKRRYSFRVPEEERMQ 1606

  Fly  1788 L-------PHYMSTLLANSGDVNLYAVAIDQRPCNGTQ--------------------------- 1818
            .       |...:.|::|..:.|..|   ...|.:|.|                           
Human  1607 QRREMLRDPEMRNKLISNPTNFNHIA---HMGPGDGIQILKDLPMPGFPYPSPHHHSGLISSPIN 1668

  Fly  1819 --KIYHLDTMQAFK--------QKFNISMETLSSVATSVTL 1849
              .|||:....|.|        .:::.|:.::....:.:||
Human  1669 FEHIYHMTVNSAEKFLSPDSINPEYSPSLRSVPGTPSFMTL 1709

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
stiNP_001261768.1 PKc_like 111..452 CDD:304357 148/350 (42%)
S_TKc 113..383 CDD:214567 120/278 (43%)
Smc 487..1222 CDD:224117 146/781 (19%)
CNH 1503..1774 CDD:279162 61/336 (18%)
CDC42BPANP_001374479.1 STKc_MRCK_alpha 4..412 CDD:270773 168/464 (36%)
SbcC 432..>941 CDD:223496 133/671 (20%)
KELK 530..608 CDD:406277 18/81 (22%)
C1_MRCKalpha 1062..1121 CDD:410414 12/91 (13%)
PH_MRCK 1123..1257 CDD:269949 30/162 (19%)
CNH 1283..1547 CDD:395630 56/306 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0612
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D759391at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR22988
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.920

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