DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sti and NBPF3

DIOPT Version :9

Sequence 1:	NP_001261768.1	Gene:	sti / 39429	FlyBaseID:	FBgn0002466	Length:	1858	Species:	Drosophila melanogaster
Sequence 2:	NP_115640.1	Gene:	NBPF3 / 84224	HGNCID:	25076	Length:	633	Species:	Homo sapiens

Alignment Length:	610	Identity:	125/610 - (20%)
Similarity:	236/610 - (38%)	Gaps:	144/610 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   531 TTCKTQIKTLQSSAKIDEEMWSKKEATITDLLRLNRQKYEEAKIASEQRYEKQLADKKQELASTL 595
            |:..|.:..:.|:..     ||.::|.: ::|.:|::.            ..|||:.||:..:..
Human    49 TSSATNVSMVVSAGP-----WSGEKAEM-NILEINKKS------------RPQLAENKQQFRNLK 95

  Fly   596 QKLDARELEF-------NAKFEECKHLSMKLQNYKDMLQQ---IKEQNLKSETNHEEQRRQ---M 647
            ||....::.:       |..:|:||.|      .|.||:.   :.|:.|..|....|:.||   :
Human    96 QKCLVTQVAYFLANRQNNYDYEDCKDL------IKSMLRDERLLTEEKLAEELGQAEELRQYKVL 154

  Fly   648 AELYEQKLTDLRKKVRDSQDTNRRMTMEIKEIRTELDESISSSKSTQEAKNATERNIEEILRRLN 712
            ....|::||.||:|:::.:|.:|.:...::.:.|..:...|..:..:|......|..:.::::|:
Human   155 VHSQERELTQLREKLQEGRDASRSLNQHLQALLTPDEPDNSQGRDLREQLAEGCRLAQHLVQKLS 219

  Fly   713 EEIASNNELHAEKVKLETKLQLKENETQEVRAECHRLERELQLAECRCQLAESSL-------ATQ 770
            .|   |::...|.||:|     :..:.||:.|     .||:|.||.: ::.|.||       :..
Human   220 PE---NDDDEDEDVKVE-----EAEKVQELYA-----PREVQKAEEK-EVPEDSLEECAITCSNS 270

  Fly   771 VSPYET-APGSLTELNAIEDQLRADLLAAKESENHQKGRADQLQTLVTKLEQMLERFNEQSLSPT 834
            ..|.|: .|...|.:...|||:.:.|:   :|.:|.    :.|..:....|...:...|:...|.
Human   271 HHPCESNQPYGNTRITFEEDQVDSTLI---DSSSHD----EWLDAVCIIPENESDHEQEEEKGPV 328

  Fly   835 KSHSSRKQEGETVGDMLERQNEKLE--DKLAAVREQMIVERQAARTANLSLWKVEKQLEEALSEK 897
            ...:.::.|.|      |...|..:  |...::...|....|:.|:...|:  .|:|:..||.
Human   329 SPRNLQESEEE------EAPQESWDEGDWTLSIPPDMSASYQSDRSTFHSV--EEQQVGLALD-- 383

  Fly   898 KLLARRMELTEDRIKKVQNASDEAQRMLKTSQEETRQRESRIEELKQELAAAKRDVLKEHRQWEK 962
              :.|..   .|::|             |..||.|..|.||  ||..|            ::.|.
Human   384 --IGRHW---CDQVK-------------KEDQEATSPRLSR--ELLDE------------KEPEV 416

  Fly   963 AEQERMKCKSEIIEHLANVHRLEQQETELRQKLRQIQSRFDGVTLEQKNTIRELQEEREKSRKAN 1027
            .:....:..|...|:|    .|.......|.....:|.:..|:.|:    :..:::::|:.....
Human   417 LQDSLDRFYSTPFEYL----ELPDLCQPYRSDFYSLQEQHLGLALD----LDRMKKDQEEEEDQG 473

  Fly  1028 DSCLVLQKELKQLTD----------------NFQRLKYACSITDSQLTEVE----------TMLK 1066
            ..|..|.:||.::.:                ::..|..:|....|....:|          ..::
Human   474 PPCPRLSRELPEVVEPEDLQDSLDRWYSTPFSYPELPDSCQPYGSCFYSLEEEHVGFSLDVDEIE 538

  Fly  1067 SEQERNKSQKSQLDTLHEKLRERND 1091
            ..||..:.||.....|:|.|.|..:
Human   539 KYQEGEEDQKPPCPRLNEVLMEAEE 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sti	NP_001261768.1	PKc_like	111..452	CDD:304357
		S_TKc	113..383	CDD:214567
		Smc	487..1222	CDD:224117	125/610 (20%)
		CNH	1503..1774	CDD:279162
NBPF3	NP_115640.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	15..52		1/2 (50%)
		DUF1220	238..296	CDD:284231	18/63 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	316..370		10/59 (17%)
		DUF1220	324..383	CDD:284231	13/66 (20%)
		DUF1220	396..458	CDD:284231	17/79 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	463..484		4/20 (20%)
		DUF1220	471..533	CDD:284231	8/61 (13%)
		DUF1220	546..608	CDD:284231	6/18 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000