Protein Alignment sti and Rock1

DIOPT Version :9

• Sequence 1: NP_001261768.1
• Gene: sti / 39429
• FlyBaseID: FBgn0002466
• Length: 1858
• Species: Drosophila melanogaster
• Sequence 2: NP_001376168.1
• Gene: Rock1 / 81762
• RGDID: 620424
• Length: 1354
• Species: Rattus norvegicus
• Alignment Length: 1664
• Identity: 408/1664 - (24%)
• Similarity: 685/1664 - (41%)
• Gaps: 485/1664 - (29%)

  Fly    66 LLDAFCLLYNECDKDTLKKRDRNIAEFVNKFRPIIEETRKLRVNADDFLIKTLIGQGYFGNVHLV 130
            |||....|..:.|...|:| ::||..|:::::..|.:.|.||:.|:|:.:..:||:|.||.|.||
  Rat    30 LLDGLDALVYDLDFPALRK-NKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLV 93

  Fly   131 VERQTNDIYAMKKIKK-SVVTTSQVK---EERDIMSIRNSEWLINLQYAFQDNDNLYLVMEYMPG 191
            ..:.|..:||||.:.| .::..|...   ||||||:..||.|::.|.|||||:..||:|||||||
  Rat    94 RHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPG 158

  Fly   192 GDLLSLMSRHGPFDEDLARFYLAELTVALHTLHEMGYVHRDIKPENILIDRFGHIKLADFGNAAA 256
            |||::|||.: ...|..||||.||:.:||..:|.||::|||:||:|:|:|:.||:||||||....
  Rat   159 GDLVNLMSNY-DVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMK 222

  Fly   257 LDRDGHVLSLSPVGTPDYIAPELLQTISTYKLSKSMHDVSRIVSCDYWSMGIIGYELICETTPFH 321
            ::::|.|...:.|||||||:||:|::        ...|......||:||:|:..||::...|||:
  Rat   223 MNKEGMVRCDTAVGTPDYISPEVLKS--------QGGDGYYGRECDWWSVGVFLYEMLVGDTPFY 279

  Fly   322 EDNVHETYSKILSHCEESHLKELISFPADLKVSVNYRNLIESLVTNPSKRL---SYERIKNHPFF 383
            .|::..|||||::|      |..::||.|..:|...:|||.:.:|:...||   ..|.||.|.||
  Rat   280 ADSLVGTYSKIMNH------KNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFF 338

  Fly   384 --SEIPWGSIRSQVPPIIPTVRSDDDTSNFEDGIRHKTRREQGVAKKSLTTNMKSNDFSGKDLPF 446
              .:..|.::|..|.|::|.:.||.|||||:|....|...|.....|:         |.|..|||
  Rat   339 KNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDKGDEETFPIPKA---------FVGNQLPF 394

  Fly   447 IGYSF---------VHMEKSAISATTDEKLQEKLKELLQKLKTRENEISMLKQDLLRAQQSLRKT 502
            :|:::         .:..::..|:..|:.:||.|::.:.||:.:.:....||.::   :|..| |
  Rat   395 VGFTYYSNRRYLPSANPSENRSSSNVDKNVQESLQKTIYKLEEQLHNEMQLKDEM---EQKCR-T 455

  Fly   503 DNKSQVVADAKMEIKKLQQIIKEKTMELTTCKTQIKTLQSSAKIDEEMWSKKEATITDLLRLNRQ 567
            .|            .||.:|:||                    :|||.              |::
  Rat   456 SN------------IKLDKIMKE--------------------LDEEG--------------NQR 474

  Fly   568 KYEEAKIASEQRYEKQLADKKQELASTLQKLDARELEFNAKFEE----CKHLSMKLQNYKDMLQQ 628
            :..|:.::..:: ||.|             |..|..|:..|.|:    .:::..::...||.|:.
  Rat   475 RNLESAVSQIEK-EKML-------------LQHRINEYQRKVEQENEKRRNVENEVSTLKDQLED 525

  Fly   629 IKEQNLKSETNHEEQRRQMAELYEQKLTDLRKKVRDSQDTNRRMTMEIKEIRTELDESISSSKS- 692
            :::.:            |.::|..:|||.|:|::.::.|.          :|||.|.::...||
  Rat   526 LRKAS------------QSSQLANEKLTQLQKQLEEANDL----------LRTESDTAVRLRKSH 568

  Fly   693 TQEAKNATERNIEEILRRLNEEIASNNELHAEKVKLETKLQLKENETQEVRAECHRLERELQLAE 757
            |:.:|:.::      |..||.|:...|             ::.||...:...:.:
  Rat   569 TEMSKSVSQ------LESLNRELQERN-------------RMLENSKSQADKDYY---------- 604

  Fly   758 CRCQLAESSLATQVSPYETAPGSLTELNAIEDQLRADLLAAKESENHQKGRADQLQTLVTKLEQM 822
                                            ||:|.|.|.:....|.......||..:|.|::.
  Rat   605 --------------------------------QLQAVLEAERRDRGHDSEMIGDLQARITSLQEE 637

  Fly   823 LERFNEQSLSPTKSHSSRKQEGE--TVGDML---ERQNEKLEDKLAAVREQMIVERQAARTANLS 882
            ::..         .|:..:.|||  ...|||   |::...||..|                 |..
  Rat   638 VKHL---------KHNLERVEGERKEAQDMLNHSEKEKNNLEIDL-----------------NYK 676

  Fly   883 LWKVEKQLEEALSEKKLLARRMELTEDRIKKVQNASD----EAQRMLKTSQEETRQRESRIEELK 943
            |..::::||:.::|.|:...|:   .|:.:.::.|..    |.::.||..:|...:.|:|:.|.:
  Rat   677 LKSIQQRLEQEVNEHKVTKARL---TDKHQSIEEAKSVAMCEMEKKLKEEREAREKAENRVVETE 738

  Fly   944 QELAAAKRDVLKEHRQWEKAEQERMKCKSEIIEHLA-NVHRLEQQETELRQKLRQ-------IQS 1000
            ::.:....|:        |..|::       :|||. |..|||.....|..:|.|       :||
  Rat   739 KQCSMLDVDL--------KQSQQK-------LEHLTENKERLEDAVKSLTLQLEQESNKRILLQS 788

  Fly  1001 RFDGVTLEQKNTIRELQEEREKSRKAN---DSCLVLQKELKQLTDNFQRLKYACSITDSQLTEVE 1062
            .......|..| ::.|  |::..::.|   ::..:|:.||.|||..::.       .:.|:.|::
  Rat   789 ELKTQAFEADN-LKGL--EKQMKQEINTLLEAKRLLEFELAQLTKQYRG-------NEGQMRELQ 843

  Fly  1063 TMLKSEQERNKSQKSQLDTLHEKLRERNDQ----LTDLRKQLTTVESEKRLAEQRA---QVLASE 1120
            ..|::||..:...|:|:..|.|::.|:|.:    :.:|:.:..|:.::..|||.:|   |:....
  Rat   844 DQLEAEQYFSTLYKTQVKELKEEIEEKNRENLRKIQELQSEKETLSTQLDLAETKAESEQLARGI 908

  Fly  1121 IDELRLNLKEQQKKLVAQQDQ-----------LVEQTNALFATQERAELLDGQNANYEAQTADSN 1174
            ::|....|.::.||..::..|           |.|..|||  |:: .|||..:|       .:.|
  Rat   909 LEEQYFELTQESKKAASRNRQEITDKDHTVSRLEEANNAL--TKD-IELLRKEN-------EELN 963

  Fly  1175 REMVSLKEENARILSELFHKKEEVGNLQAEI-------RGLESAQANLHAEIDSLQD-------- 1224
            ..|.:.:||..      ..|:||:.||:|..       |.|::...|..|||.:.:|
  Rat   964 ERMRTAEEEYK------LKKEEEISNLKAAFEKNISTERTLKTQAVNKLAEIMNRKDFKIDRKKA 1022

  Fly  1225 -----TLAEKEQFYVQRDI-----KSNATLAQHKKLIDYLQLK---------------------V 1258
                 ...|||...:|.::     |.|..:.:|:|.::.:|.:                     :
  Rat  1023 NTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLVEECTHRNELQMQLASKESDI 1087

  Fly  1259 EDLSAKKKKTLADKLFGSSHTNKENVSPNDVESSI---LYRALKEELKREQKMNSLLKEQLAQLN 1320
            |.|.| |...|:|....:|..:.:....|..||.|   |....:..:||..     .|:|...:
  Rat  1088 EQLRA-KLLDLSDSTSVASFPSADETDGNLPESRIEGWLSVPNRGNIKRYG-----WKKQYVVV- 1145

  Fly  1321 GTATLRSPRKSAAVNGDSDAPKQRPVSIAALPR----SPQKQQQPLKRTTSQV------------ 1369
                  |.:|....|.:.|..:..|..:..:.:    .|..|....:..|.::
  Rat  1146 ------SSKKMLFYNDEQDKEQSSPSMVLDIDKLFHVRPVTQGDVYRAETEEIPKIFQILYANEG 1204

  Fly  1370 ELKTTAE-KPT----KVTIENQAHHRFELALQESKVDAVNCVVCEKAVVAGSPFW---------K 1420
            |.:...| :|.    |...:|...|.|...|...   ..||..|.|      |.|         :
  Rat  1205 ECRKDIEVEPVQQGEKTNFQNHKGHEFIPTLYHF---PANCEACAK------PLWHVFKPPPALE 1260

  Fly  1421 CKECKDVTHRKCRSNVQSHCGSTKPTAPSADDLSSIQSVSSLTLDSVDVAGGTTSGGEYIGSLVY 1485
            |:.|    |.||.   :.|       ....:||.|...||                        |
  Rat  1261 CRRC----HVKCH---RDH-------LDKKEDLISPCKVS------------------------Y 1287

  Fly  1486 SSDGAEDQARKEIEVNCAFEVAEQQILLLGCNTGLYAYHLDSQR--LVHISGLESVSCMSICKRL 1548
            ....|.|                  :|||.|:.       |.|:  :.|           :.|::
  Rat  1288 DVTSARD------------------MLLLACSQ-------DEQKKWVTH-----------LVKKI 1316

  Fly  1549 AKAIMVGTVGEKLYQCDYRQLESRCQSSSSCHKPVLETS 1587
            .|....|.|     :...|.|.:|..::.|..|.|..||
  Rat  1317 PKNPPSGFV-----RASPRTLSTRSTANQSFRKVVKNTS 1350

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sti	NP_001261768.1	PKc_like	111..452	CDD:304357	143/358 (40%)
		S_TKc	113..383	CDD:214567	118/276 (43%)
		Smc	487..1222	CDD:224117	162/784 (21%)
		CNH	1503..1774	CDD:279162	19/87 (22%)
Rock1	NP_001376168.1	STKc_ROCK1	2..406	CDD:270772	158/400 (40%)
		Interaction with FHOD1. /evidence=ECO:0000250	368..727		102/543 (19%)
		SMC_prok_B	426..>1097	CDD:274008	180/888 (20%)
		HR1_ROCK1	489..554	CDD:212029	17/99 (17%)
		SHROOM3 binding. /evidence=ECO:0000250|UniProtKB:Q13464	707..946		59/263 (22%)
		ROCK_SBD	836..913	CDD:409019	19/76 (25%)
		RHOA binding. /evidence=ECO:0000250	998..1010		4/11 (36%)
		PH_ROCK	1119..1225	CDD:269948	19/117 (16%)
		C1_ROCK1	1222..1290	CDD:410424	22/114 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920