DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sti and Rpgrip1

DIOPT Version :9

Sequence 1:	NP_001261768.1	Gene:	sti / 39429	FlyBaseID:	FBgn0002466	Length:	1858	Species:	Drosophila melanogaster
Sequence 2:	XP_006519752.1	Gene:	Rpgrip1 / 77945	MGIID:	1932134	Length:	1371	Species:	Mus musculus

Alignment Length:	1342	Identity:	259/1342 - (19%)
Similarity:	471/1342 - (35%)	Gaps:	376/1342 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   335 HCEESHLKE---LISFPADLKVSVNYR---NLIESLVTNPSKR----LSYERIKNHPFFSEIPWG 389
            :|...||.|   |:..|:..:...|.|   |:..|..|.|..|    |.....:..|:.|..|..
Mouse    97 NCRRLHLHEEPTLVKEPSPKQRDKNRRRRTNVQRSTTTQPDLRTLAVLQEPERRRRPWVSASPSP 161

  Fly   390 SI--RSQVP----------PI---------------IPTVRSDDDTSN------FEDGIRHK-TR 420
            |.  |:.||          |.               :|.:...:|..:      |:|.:..| ||
Mouse   162 SAPPRAPVPGRKAHVQRLCPSTAVGSAQPRVHAGRRLPHIAGPNDRRSHTAPPAFKDYVADKNTR 226

  Fly   421 REQGVAKKSLTTNMKSNDFSGKDLPFIGYSFVHMEK-------------SAISATTDEKLQ-EKL 471
            .|.......||..|.::....:::|........:||             :.:.|:..|.:: .:|
Mouse   227 IEITREPSQLTHTMTTDSTHVEEIPRSPEKTSKVEKPEQRSSEECTQKAAELRASIKENVELIRL 291

  Fly   472 KELLQKLKTRENEISMLKQDLLRAQQSLRKTDNKSQVVADAK-----MEIKKLQQIIKEKTMELT 531
            |:|||:   |...::..:..|.|.|::......|:|.:.|..     .::.:|:..:.|::.:..
Mouse   292 KKLLQE---RNTSLAATEAQLTRVQEAYEDLLQKNQGILDTAHNAFLSQVNELKAELSEESKKAV 353

  Fly   532 TCKTQ---IKTLQSSAKIDEEMWSKKEATITDLLRLNRQKYEEAKIAS---EQRYEKQLADKKQE 590
            :.:||   :..||.:.|       :.:..:.||       .:|.|:.|   ::..|..|....|.
Mouse   354 SLRTQLGDVSILQITLK-------EFQVRVEDL-------EKERKLLSDSYDRLLENMLDSSHQP 404

  Fly   591 LASTLQ-----KLDAREL---------EFNAKFEECKHL-----------SMKLQNYKDMLQQ-- 628
            |.|:.|     :|..::|         :.....||.|..           .:|.|: .|:|.|
Mouse   405 LDSSHQPHWSTELTGKQLPPQVCPLLDQMGTALEETKVFRQATNKAAQDGKLKFQD-TDILYQHE 468

  Fly   629 IKEQNLKSETNHEEQRRQMAELYEQKL----TDLRKKVR-DSQDTNRRMTMEIKEIRTELDESIS 688
            .:|::|:|.........::.||..|..    ||.|:... .:||.|     ::.::.:||  .:|
Mouse   469 QEEESLQSTATVASSPEELCELAAQPTLLPQTDQRESSEPKAQDEN-----DLSQVLSEL--QVS 526

  Fly   689 SSKSTQEAKNATERNIEEILRRLNEEIASNNELHAEKVKLETKLQLKENETQEVRAECHRLEREL 753
            .:::|.|.:..  |::..:.|::|  :....||.|...|.:     :||...|.:.|  ||...|
Mouse   527 HAETTLELEKT--RDMLLLQRKIN--MCYQEELEATLTKAD-----RENRDHEEKLE--RLNHLL 580

  Fly   754 QLAECRCQLAESSLATQVSPYETAPGSLTELNAI-----EDQLRADLLAAKES--ENH------- 804
            .....|.:..|..|....  |.|.|.||. |..:     :|::...||...|:  |.|
Mouse   581 DFKNSRIKQLEEQLKDVA--YGTLPPSLC-LEPLAAHRGDDEVDMSLLHPSENLFELHVHQAFLT 642

  Fly   805 -----QKGRAD----------QLQTLVTKLE---QMLERFNEQSLSPTKSHSSRKQEGETVGDML 851
                 |.|...          ..:|..|.|.   |.|..|..|.:         .|....:...|
Mouse   643 PAALTQAGDTQPTTFCTYSFYDFETHCTPLSTGPQPLYDFTSQYV---------VQADYLLLHYL 698

  Fly   852 ERQNEKLEDKLAAVREQMIVERQAARTANLSLWKVEKQLE------------------------- 891
            :..:.:|:     :.:.|..|.....|..:||.||...:|
Mouse   699 QGTSVRLD-----LHQAMASEYHVLATGWISLDKVLGTVERVHGLATLAGAGGEDLGVLEYWMRL 758

  Fly   892 --------EALSEKKLLARRMELTEDRIKKVQNASDEAQRMLKTSQEETRQRESRIEELKQELAA 948
                    :|.:::|.....:.::....:|||  |:|::......|.|.|...:|...|:.....
Mouse   759 CLPLKPSLQACNKRKKAQAYLSVSVLGARKVQ--SNESRSETWAPQNELRVEITRCCGLRSRRLG 821

  Fly   949 AKRDVLKEHRQWEKAEQERMKCKSEIIEHLANVHRLEQQ------ETELRQKLRQIQSR---FDG 1004
            .:......:|.:...:.:.:     ||...:|.:..:|.      .::|.|.||:....   ||.
Mouse   822 RQPSPYVMYRFFTFPDHDTI-----IIPASSNPYFKDQALFPVLVTSDLDQYLRREALSVYVFDD 881

  Fly  1005 ----------------VTLEQKNTIR---ELQEEREKSRKANDSCLVLQKELKQ---LTDNFQRL 1047
                            :.|.|..:|:   .|.:..|||    :..:.:|.:.|.   ..:.|
Mouse   882 EDPEPGSYLGRAQVPLLPLAQNKSIKGDFNLTDSGEKS----NGSIKVQLDWKSHYLAPEGF--- 939

  Fly  1048 KYACSITDSQLTEVETMLKSEQERNKSQKSQLDTLHEKLRERNDQLTDLRKQLTTVESEKRLAEQ 1112
                     |::|.|   |.|.|..:.:..:.:...|::.|..::          .|.|:.:.|:
Mouse   940 ---------QMSEAE---KPEGEEKEEEGGEEEVKEEEVEEEEEE----------EEEEEEVKEE 982

  Fly  1113 RAQVLASEIDELRLNLKEQQKKLVAQQDQLVEQTNALFATQERAELLDGQNANYEAQTADSNREM 1177
            :.:....|.:|  ...||::|:...::|:..|:..     :|..|..:.::.|.:...|....|.
Mouse   983 KEEEEEEEREE--EEEKEEEKEEEEEEDEKEEEEE-----EEEEEEEEEEDENKDVLEASFTEEW 1040

  Fly  1178 VSLKEENARILSEL------FHKKEE---VGNLQAEIRGLESAQANLHAEIDSLQDTLAEKEQFY 1233
            |....::....:|:      :.:|.:   :...:.....:.|.....|::...:||   :....|
Mouse  1041 VPFFSQDQIASTEIPIEAGQYPEKRKPPVIAEKKEREHQVASYSRRKHSKKPGVQD---KNRMEY 1102

  Fly  1234 VQRDIKSNATLAQHKKLIDYLQLKVEDLSAKKKKTLADKLFGSSHTNKENVSPNDVESSILYRAL 1298
            :..:|.:..|...|     |.:.|...|     |...|....:....:|..||..        ||
Mouse  1103 LSCNILNGNTQQMH-----YTEWKFSGL-----KKAEDGGLKAQDKREEPPSPRS--------AL 1149

  Fly  1299 KEELKREQKMNSLLK-----EQLAQLNGTATLRS------PRKSAAVNGDSDAPKQRPVSIAALP 1352
            ::|.....:....|.     ||.::::.|.|..|      |:.......||:......||:|..|
Mouse  1150 RQEHPSHPRNAFSLADQESCEQASEVSETQTTDSDDIIVTPQAQTVPKADSEKMCIEIVSLAFCP 1214

  Fly  1353 R----SPQKQQQ----------PLKRTTSQVELKTTAEKP----------TKV----TIENQAHH 1389
            .    |.:..||          ||..|.:.:.|:    ||          :||    .:|:|:..
Mouse  1215 EADVMSDETIQQVYVEYKFCDLPLSETETPMSLR----KPRAGEEIHFHFSKVIDLDPVEHQSRR 1275

  Fly  1390 RFELAL---QESKVDAVNCVVCEKAVVAGSPF-WKCKECKDV 1427
            :|..|:   |:|.....      |..|...|. .:.|||:|:
Mouse  1276 QFLFAMLHAQDSDEGRF------KFTVVSDPLDEEKKECQDI 1311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sti	NP_001261768.1	PKc_like	111..452	CDD:304357	34/160 (21%)
		S_TKc	113..383	CDD:214567	15/57 (26%)
		Smc	487..1222	CDD:224117	161/882 (18%)
		CNH	1503..1774	CDD:279162
Rpgrip1	XP_006519752.1	SMC_prok_B	270..>594	CDD:274008	75/359 (21%)
		C2-C2_1	623..758	CDD:371629	25/148 (17%)
		C2	805..912	CDD:175973	17/111 (15%)
		SPG4	1083..>1147	CDD:340041	15/76 (20%)
		RPGR1_C	1199..1364	CDD:375560	30/123 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000