DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sti and cdc42bpb

DIOPT Version :9

Sequence 1:NP_001261768.1 Gene:sti / 39429 FlyBaseID:FBgn0002466 Length:1858 Species:Drosophila melanogaster
Sequence 2:XP_004917233.2 Gene:cdc42bpb / 733471 XenbaseID:XB-GENE-1005934 Length:1731 Species:Xenopus tropicalis


Alignment Length:2026 Identity:483/2026 - (23%)
Similarity:785/2026 - (38%) Gaps:636/2026 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    60 AICREGLLDAFCLLYNECDKDTLKKRDRNIAEFVNKFRPIIEETRKLRVNADDFLIKTLIGQGYF 124
            |:..|.|||....||.||...|| :||:.::||:...:|..:..:.::::.|||.|..:||:|.|
 Frog    24 ALSVETLLDVLLCLYTECSHSTL-RRDKYVSEFLEWAKPFTDLLKGMQLHRDDFEIIKVIGRGAF 87

  Fly   125 GNVHLVVERQTNDIYAMKKIKK----SVVTTSQVKEERDIMSIRNSEWLINLQYAFQDNDNLYLV 185
            |.|.:|..:.|..|||||.:.|    ....|:..:|||:::...:.:|:.:|.|||||.:.||||
 Frog    88 GEVAVVRLKSTERIYAMKILNKWEMLKRAETACFREERNVLVNGDCQWITSLHYAFQDENYLYLV 152

  Fly   186 MEYMPGGDLLSLMSR-HGPFDEDLARFYLAELTVALHTLHEMGYVHRDIKPENILIDRFGHIKLA 249
            |:|..|||||:|:|: .....||:|||||||:.:|:|::|::.||||||||:|:|:|..|||:||
 Frog   153 MDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVLAIHSIHQLHYVHRDIKPDNVLLDMNGHIRLA 217

  Fly   250 DFGNAAALDRDGHVLSLSPVGTPDYIAPELLQTISTYKLSKSMHD-VSRI-VSCDYWSMGIIGYE 312
            |||:...::.||.|.|...|||||||:||:||         :|.| :.:. ..||:||:|:..||
 Frog   218 DFGSCLKMNADGTVQSSVAVGTPDYISPEILQ---------AMEDGMGKYGPECDWWSLGVCMYE 273

  Fly   313 LICETTPFHEDNVHETYSKILSHCEESHLKELISFPADL-KVSVNYRNLIESLVTNPSKRLSYER 376
            ::...|||:.:::.|||.||::|      :|...||:.: .||.:.:::|:.|:.:..:||....
 Frog   274 MLYGETPFYAESLVETYGKIMNH------EERFQFPSHIGDVSESAKDVIQRLICSRERRLGQNG 332

  Fly   377 I---KNHPFFSEIPWGSIRSQVPPIIPTVRSDDDTSNFEDGIRHKTRREQGVAKKSLTTNMKSND 438
            |   |.||||..|.|.:||:...|.||.|.|..|||||:  :.....|...|...|     ..:.
 Frog   333 IDDFKAHPFFEGIDWDNIRNLEAPYIPDVSSPYDTSNFD--VDDDVLRNPEVIPPS-----THSG 390

  Fly   439 FSGKDLPFIGYSFVHMEKSAISATTDEKLQEK--LKELLQKLKTRENEISMLKQDLLRAQQSLRK 501
            |||..|||:|:::          |||....::  ||:.:......::|      |:.|..|    
 Frog   391 FSGFHLPFVGFTY----------TTDSCFSDRGSLKDTIHSNAVTKDE------DVQRGLQ---- 435

  Fly   502 TDNKSQVVADA-KMEIKKLQQIIKEKTMELTTCKTQIKTLQSSAKIDEEMWSKKEATITDLLRLN 565
              |..|:  || :..|::|:|...|...:|......:::||..::....:..:||     :.:||
 Frog   436 --NSLQI--DAYERRIRRLEQEKLELNRKLQESTQTVQSLQGGSRTTGTLTREKE-----IRKLN 491

  Fly   566 RQ-KYEEAKIASEQRYEKQLADKKQELASTLQKLDARELEFNAKFEECKHLSMKLQNYKDMLQQI 629
            .: :..:.||:...|.|:||.|.                           :::: |.|:|...::
 Frog   492 EEIERLKNKISDSNRIERQLEDV---------------------------VALR-QQYEDSTNKM 528

  Fly   630 KEQNLKSETNHEEQRRQMAELYEQKLTDLRKKVRDSQDTNRRMTMEIKEIRTELDESISSSKSTQ 694
            |        ..|:|.|.:    :|:..||:|:..|:|:..:..|.|:|:              ..
 Frog   529 K--------GLEKQHRAL----KQERDDLQKQFSDAQERLKSQTKELKD--------------AN 567

  Fly   695 EAKNATERNIEEILRRLNEEIASNNELHAEKVKLETKLQLKENETQEVRAECHRLERELQLAECR 759
            :.:..|::...|    |.|::|   ||.::|:||..:|:.||.|                     
 Frog   568 QHRKVTQQEFAE----LTEKMA---ELRSQKLKLSRQLRDKEEE--------------------- 604

  Fly   760 CQLAESSLATQVSPYETAPGSLTELNAIEDQLRADLLAAKESENHQKGRADQLQTLVTKLEQMLE 824
                                                                |:.::.|::.|  
 Frog   605 ----------------------------------------------------LELVMQKIDTM-- 615

  Fly   825 RFNEQSLSPTKSHSSRKQEGETVGDMLERQNEKLEDKLAAVREQMIVERQAARTANLSLWKVEKQ 889
                            :||        .|::||...:|                        |.|
 Frog   616 ----------------RQE--------NRKSEKARKEL------------------------EAQ 632

  Fly   890 LEEALSEKKLLARRMELTEDRIKKVQNASDEAQRMLKTSQEETRQRESRIEELKQELAAAKRDVL 954
            |::|.:|                    ||.| :::.:.|:...:|.||.:|.||.:.........
 Frog   633 LDDATAE--------------------ASKE-RKLREHSEIFCKQLESEVESLKLKQGVRTPGAT 676

  Fly   955 KEHRQWEKAEQERMKCKSEIIEHLANVHRLEQQETELRQKLRQIQSRFDGVTLEQKNTIRELQEE 1019
            .||      :||..|.|||          ||::.....::|.:   |....:.|.||..:|:.:.
 Frog   677 LEH------QQELSKVKSE----------LEKKNLYFEEELLR---RETAHSFEMKNIKKEIHDS 722

  Fly  1020 REKSRKANDSCLVLQKELKQLTDNFQRLKYACSITDSQLTEVETMLKSEQERNK----------- 1073
            ..:.       |.|:||...|.|..::.|..   ..|:|.|....:|.:.||.:           
 Frog   723 ESQQ-------LALKKETLMLKDKLEKAKRE---RQSELEEAVGAVKEKYERERSILLDENKKLF 777

  Fly  1074 SQKSQLDTLHEKLRERNDQLTDLRKQLTTVESEKRLAEQRAQVLASEIDELRLNLKEQQKKLVAQ 1138
            ||..:|.:..:||.|:|.||.|..:.||.  .::.:|...||:  :||.:...:.|:.:..|.|.
 Frog   778 SQTERLSSFVDKLTEQNRQLEDDLQDLTA--KKESVAHWEAQI--AEIIQWVSDEKDARGYLQAL 838

  Fly  1139 QDQLVEQTNALFATQERAELLDGQNANYEAQTADSNREMVSLKEENARILSELFHKKEEVGNLQA 1203
            ..::.|:..:|.::...:..|...:........:|:|.....|...::.| ::..:.|....|.|
 Frog   839 ASKMTEELESLRSSSLGSRALPDLSFPQGLAPYNSDRLDPLWKVRRSQKL-DMSARLELQSALDA 902

  Fly  1204 EIRGLESAQANLHAEIDSLQDTLAEKEQFYVQRDIKSNATLAQHKKLIDYLQLKVEDLSAKKKKT 1268
            |||..:..|..|....||  :.|.|.                           |::|...|.|:.
 Frog   903 EIRAKQVVQEELRKAKDS--NILFES---------------------------KLKDAELKNKEL 938

  Fly  1269 LADKLFGSSHTNKENVSPNDVESSILYRALKEELKREQKMNSLLK-----EQLAQLNGTA----- 1323
            |.:         .||              ||::|:.:.|.:|.||     |.:.:...|:     
 Frog   939 LEE---------MEN--------------LKKKLEEKYKDDSGLKIPDFHESIFEYFNTSPLPHD 980

  Fly  1324 -TLRSPRKSAAVNGDSDAPKQRP-VSIAALPRSPQKQQQPLKRTTSQVELKTTAEKPT----KVT 1382
             ||||...|     :.|.|..:| ||.:....|...||:.|.|:.|:.:   .|..||    .|:
 Frog   981 LTLRSSTIS-----EPDIPSPKPEVSASLAHPSTNDQQEELSRSQSRTQ---PAPSPTFTPISVS 1037

  Fly  1383 IENQAHHRFELALQESKVDAVNCVVCEKAVVA----GSPFWKCKECKDVTHRKCRS--------- 1434
            |.....|:.   :.:|.|:...|..|...:|.    |   :.|:.|....|..|:.         
 Frog  1038 IPKPKAHQL---IIKSFVNPTQCSHCTSLMVGLVRQG---YACEVCPFACHVSCKDSAPQVCPIP 1096

  Fly  1435 ----------NVQSHCGST--------KPTAPSADDLSSIQSVSSLTLDSVDVAGGTTSGGEYIG 1481
                      :||...|:.        |||........:...|....|...||..|.::....:.
 Frog  1097 AEQAKRPLGVDVQRGIGTAYKGYVRIPKPTGVKKGWQRAFAVVCDCKLFLYDVPEGRSTQPGVVS 1161

  Fly  1482 SLV---------YSSDGAED---QARKEIEVNCAFEVAEQ----------QILLL---------- 1514
            |.|         .||..|.|   ..||:|.  |.|.|...          .:|:|          
 Frog  1162 SQVVDLRDEDFSVSSVLASDVIHATRKDIP--CIFRVTASLLGSPSKTTASLLILTESEAEKRKW 1224

  Fly  1515 -GCNTGLYAYHLDS---QRLVHISGLESVSCMSICKRLAKA-------IMVGTVGEKLYQCDY-R 1567
             |...||.|....:   .|.||.......|.:.:.|.:..|       |.||| .|.||..:. |
 Frog  1225 VGILEGLQAILQKNNLRNRAVHCPQEAYDSTLPLIKTIVAAAVVDHDRIAVGT-EEGLYVIEVTR 1288

  Fly  1568 QLESRCQSSSSCHKPVLETSAIELPFANRTPSEKWKLVLIS-------------DEAENALD--- 1616
            .:..|   ::.|.|    ...|||     .|.||..:::..             |.:|.:.|   
 Frog  1289 DVIVR---AADCKK----VYQIEL-----VPKEKIVILVCGRNHHVHLFPWSSLDGSEGSFDIKL 1341

  Fly  1617 ------------SVAIAATSTRIVILKYDL---KLHMFKPVRALDTATPVTSIFFTRHSAIVS-- 1664
                        |:..:.:....|.:|..:   ::|..||             |..:.:.||:  
 Frog  1342 PESKGCQFITTGSLKKSVSPCLFVAVKRQIFCYEIHRTKP-------------FHKKFNEIVAPG 1393

  Fly  1665 --------SDKF---YE--------------IDLDNYAAEEFVDLSDKSMESTAKCQPLTAVRIS 1704
                    .||.   |:              |:|.|........||.:.:::      |.||.:|
 Frog  1394 NVQWMAVFKDKLCVGYQSGFSLLTIHGEGQPINLVNPNDPSLAFLSQQPVDA------LCAVELS 1452

  Fly  1705 RQEYLLCFAEYGVFVDEFGCRSRPYDLNW---------------VYAPTGFVYRDPFLFISHYQS 1754
            :.||||||::.|::||..|.|:|..:|.|               ||:..|....|    :|..:.
 Frog  1453 KDEYLLCFSQLGIYVDSQGRRTRMQELMWPATPLACSCSSSYVTVYSEYGIDVFD----VSTMEW 1513

  Fly  1755 VQIVRLHR------SFSKEMASGDNA--------------------SENSES------------- 1780
            ||.:.|.|      ..|..:.:.:.|                    |:||:.             
 Frog  1514 VQTIGLRRIKPLNAEGSLNLLNSEPARLLYLKSIYSEGPILTVPETSDNSKKQMVRTRSKRKFVF 1578

  Fly  1781 --PELQRVYL-------PHYMSTLLANSGDVNLYAVAIDQRPCNGTQKIYHLDTMQAFKQKFNIS 1836
              ||.:|:..       |...|.:::|..:.|..|   ...|.:|.|.:..|........:...|
 Frog  1579 KVPEEERLQQRREMLRDPELRSKMISNPTNFNHVA---HMGPGDGMQVLMDLPLSVVPSSQDENS 1640

  Fly  1837 METLSSVATSV 1847
            .|.|...:|:|
 Frog  1641 RERLRPPSTNV 1651

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
stiNP_001261768.1 PKc_like 111..452 CDD:304357 145/351 (41%)
S_TKc 113..383 CDD:214567 117/280 (42%)
Smc 487..1222 CDD:224117 144/747 (19%)
CNH 1503..1774 CDD:279162 79/381 (21%)
cdc42bpbXP_004917233.2 STKc_MRCK_beta 3..411 CDD:270774 164/419 (39%)
Smc <375..804 CDD:224117 134/696 (19%)
KELK 528..606 CDD:406277 27/183 (15%)
DMPK_coil 895..944 CDD:117396 17/86 (20%)
C1_MRCKbeta 1044..1096 CDD:410415 11/57 (19%)
PH_MRCK 1103..1238 CDD:269949 29/136 (21%)
CNH 1264..1529 CDD:395630 65/300 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D759391at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR22988
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
22.110

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