DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sti and Mad1l1

DIOPT Version :9

Sequence 1:	NP_001261768.1	Gene:	sti / 39429	FlyBaseID:	FBgn0002466	Length:	1858	Species:	Drosophila melanogaster
Sequence 2:	NP_001102857.1	Gene:	Mad1l1 / 680006	RGDID:	1596881	Length:	717	Species:	Rattus norvegicus

Alignment Length:	785	Identity:	166/785 - (21%)
Similarity:	311/785 - (39%)	Gaps:	194/785 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   683 LDESISSSKSTQEAKNATERNIEEILRRLNEEIASNNELHAEKVKLETKLQLKENETQEVRAECH 747
            ||.|.|:|.|.|:   ..|:|::  |....|:|.|.:.|                    ::.|..
  Rat    31 LDVSTSASGSLQK---QYEQNMQ--LEERAEQIRSKSYL--------------------IQVERE 70

  Fly   748 RLERELQLAECRCQLAESSLATQVSPYETAPGSLTELNAIEDQLRADLLAAKESENHQKGRADQL 812
            :::.||.....|.:| |.:.:|....||.......||.|...||:....||:|
  Rat    71 KMQMELSHKRARVEL-ERAASTNARNYEREVDRNQELLARIRQLQEREAAAEE------------ 122

  Fly   813 QTLVTKLEQMLERFN--EQSLSPTKSHSSRKQEGETVGDMLERQNEKLEDKLAAVREQMIVERQA 875
                 |:.:.|||..  :|||                 |...:|..:.||.|||.||.:...:..
  Rat   123 -----KMREQLERHRLCKQSL-----------------DAASQQLREREDGLAAARETISSLKGR 165

  Fly   876 ARTANLSLWKVEKQLEEALSEKKLLARRMELTEDRIKKVQNASDEAQRMLKTSQEETRQRESRIE 940
            .....||....:.|::...|||:.|..::||.:   :|.|.|:.:.|. |:.||||...:|.:|:
  Rat   166 VSELQLSAMDQKVQVKRLESEKQELKEQLELQQ---RKWQEANQKIQE-LQASQEERTDQEQKIK 226

  Fly   941 ELKQEL------AAAKRDVLKEHRQWEKAEQERMKCKSEIIEHLANVHRLEQQETE--------- 990
            :|:|:|      ||..:.:..|..:..:.|:|..:.:.|      |.|..|.:||.
  Rat   227 DLEQKLCLQEQDAAVVKSMKSELLRLPRMERELKRLREE------NTHLREMRETNGLLTEELEG 285

  Fly   991 LRQKL---RQIQSRFDGVTLEQKNTIRELQ--EEREKSRKANDSCLVLQKELKQLTDNFQRLKYA 1050
            |::||   .::|.....:.||::..:.:||  |:.:::...|   |...::|.:.....|:.:.|
  Rat   286 LQRKLGRQEKMQEALVDLELEKEKLLAKLQSWEKLDQTMGLN---LRTPEDLSRFVIELQQRELA 347

  Fly  1051 CSITDSQLTEVETMLKSEQERNKSQKSQLDTLHEKLRERNDQLTDLRKQLTTVESEKRLAEQRAQ 1115
            ....:|.:|.....|:..|::          |.:::|:.|.||.:.||:..|.|:..|..::|..
  Rat   348 LKEKNSSITSSARGLEKAQQQ----------LQDEVRQVNAQLLEERKKRETHEALARRLQKRNA 402

  Fly  1116 VLASEIDELRLNLKEQQKKLVAQQDQLVEQTNALFATQERAELLDGQNANYEAQTADSNREMVSL 1180
            :|..|.|.:|..|.....:| .|.:...:.|..::..::..:.:...::..|||.:.:
  Rat   403 LLTKERDGMRAILGSYDSEL-TQAEYSPQLTQRMWEAEDMVQKVHAHSSEMEAQLSQA------- 459

  Fly  1181 KEENARILSELFHKKEEVGNLQAEIRGLESAQANLHAEIDSLQDTLAEKEQFYVQRDIKSNATLA 1245
                   |.||..:|:....|:.|::.|.:            |.:.||             |:..
  Rat   460 -------LEELGVQKQRADTLEMELKMLRA------------QTSSAE-------------ASFP 492

  Fly  1246 QHKKLIDYLQLKVEDLSAKKKKTLADK-----------LFGSSHTNKENVSPNDVESSILYRALK 1299
            ..|:.:|.|:||||:|..::.:...:|           |.|..:.::..|....:..:.:.|
  Rat   493 FCKEEVDALRLKVEELEGERSRLEQEKQALEMQMERLTLQGDYNQSRTKVLHMSLNPASMAR--- 554

  Fly  1300 EELKREQKMNSLLKEQLAQLNGTATLRSPRKSAAVNGDSDAPKQRPVSIAALPRSPQKQQQPLKR 1364
               :|:::.:..|:|:..:|.|  .:.:..:...:..|.:|....|.|         |:...|::
  Rat   555 ---QRQREDHDRLQEECERLRG--LVHALERGGPIPADLEAASSLPSS---------KEVAELRK 605

  Fly  1365 TTSQVELKTTAEKPT------------------KVTIENQAHHRFELALQESKVDAVNCVVCEKA 1411
            .....|||....|..                  ::.:..::.:|......|.:.|   |::.:..
  Rat   606 QVESAELKNQRLKEVFQTKIQEFRKVCYTLTGYQIDVTTESQYRLTSRYAEHQTD---CLIFKAT 667

  Fly  1412 VVAGS 1416
            ..:||
  Rat   668 GPSGS 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sti	NP_001261768.1	PKc_like	111..452	CDD:304357
		S_TKc	113..383	CDD:214567
		Smc	487..1222	CDD:224117	128/560 (23%)
		CNH	1503..1774	CDD:279162
Mad1l1	NP_001102857.1	MAD	54..715	CDD:283261	156/757 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000