DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sti and dzip1

DIOPT Version :9

Sequence 1:	NP_001261768.1	Gene:	sti / 39429	FlyBaseID:	FBgn0002466	Length:	1858	Species:	Drosophila melanogaster
Sequence 2:	XP_005165761.1	Gene:	dzip1 / 402875	ZFINID:	ZDB-GENE-040526-1	Length:	907	Species:	Danio rerio

Alignment Length:	1021	Identity:	216/1021 - (21%)
Similarity:	361/1021 - (35%)	Gaps:	310/1021 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   709 RRLNEEIASNNELHAEKVKLETKLQLKENETQEVR------AECHRLERELQLAECRCQLAESSL 767
            ||.|.:....|.:..::|..|...|..:.....|.      ..||           |||
Zfish    70 RRENVDWRRINAVDVDRVACEMDFQALQEHINAVTFCSVEGERCH-----------RCQ------ 117

  Fly   768 ATQVSPYETAPGSLTELNAI--------EDQLRADLLAAKESENHQKGRADQLQTLVTKLEQMLE 824
                ||.:.|...|..|..:        :|.|...|.||:|          :|.....:.||:..
Zfish   118 ----SPVDPALIKLFRLAQLTVEYLLHSQDCLSISLQAAEE----------RLLAEAREREQICV 168

  Fly   825 RFNEQSLSPTKSHSSRKQEGETVGDMLERQNEKLEDKLAAVREQMIVERQAARTANLS-----LW 884
            :..:::           |:.:.:.:.|::            |:::|..:||..:|.:|     ..
Zfish   169 QLQKKT-----------QDAKALKEELKQ------------RKKIIASQQAMFSAGISANYHKCQ 210

  Fly   885 KVEKQLEEALSEKKLLARR------MELTEDRIKKVQNA--SDEAQRM-----LKTSQEETRQRE 936
            ..||....|...:..:.||      |:|..|..||:|..  .||..::     |.|||.||:|::
Zfish   211 HCEKAFMNASFLQSHMQRRHPSEFDMKLMTDNQKKIQTVKLQDEINKLQEQLTLVTSQMETQQKD 275

  Fly   937 SRIEELKQELAAAKRDVLKEHRQWEKAEQERMKCKSEIIEHLANVHRLEQQETE-LRQKLRQIQS 1000
            ...:: ::||...:.:..::...|:  |:|:|:..|:|.|    |.:..|::.: :.|:.|.:::
Zfish   276 YTAKQ-EKELIQRQEEFKRQLEIWK--EEEKMRMNSKIDE----VKQACQRDMDSMHQRNRNLET 333

  Fly  1001 RFDGVTLEQKNTIRELQ--EEREKSRKAND---SCLVLQKELKQLTDNFQRLKYACSITDSQLTE 1060
            ..  :.|:|||....:|  :.:..:..:|:   ..:.||::|.:     |.:|:         |.
Zfish   334 EL--LKLQQKNIQESMQSVQTQPNASASNEHWQEVVKLQQKLHK-----QEVKW---------TG 382

  Fly  1061 VETMLKSEQERNKSQKSQLDTLHEKLRERNDQLTDLRKQLTTVES--EKRLAEQRAQVLASEIDE 1123
            ....:|.:.:|.||......::|.:|:|          :|..|.|  .:.:.|.|.||     .|
Zfish   383 KMQKMKEDHDREKSLSPTRLSVHRQLQE----------ELCKVSSAVSEGMEESRRQV-----QE 432

  Fly  1124 LRLNLKEQQKKLVAQQDQLVEQTNALFATQERAELLDGQNANYEAQTADSNREMVSL--KEENAR 1186
            |...|:|||:.:.:|..|:                   :..:.:..|....||.||.  .|..|:
Zfish   433 LSHRLQEQQQIITSQNKQM-------------------KQISSKPPTITVQREGVSTPSPETKAK 478

  Fly  1187 IL----SELFHKKEEVGNLQAEIRGLESAQANLHAEIDSLQDTLAEKEQFYVQRDIKSNATLAQH 1247
            ::    |...||.:.:..|..|.:. .|:.:....|..|.|   .|.::......::.:..||..
Zfish   479 VVVSEQSNSVHKLDPIVELSEEDKD-SSSISESPTENRSWQ---KEVQELLKNPGLRRDMRLAAQ 539

  Fly  1248 KKLIDYLQLKVEDLSAKKKKTLADKLFGSSHTNKENVSPNDVESSILY-RALKE----------E 1301
            ..|.|.||    .|..|....|:..|:.||.|...:.....:|...:| |||||          |
Zfish   540 HNLDDRLQ----SLGIKGVSGLSKNLYKSSMTQIISDRRKKLEEDPVYRRALKEISHKLEQRVKE 600

  Fly  1302 LKREQKMNSLLKEQLAQLNGTATLRSPRKSAAVNGDSDAPKQRPVSIAALPRSP-QKQQ---QPL 1362
            ...||.:...|.||:.|       ..||.|:.           |.::..:...| .|||   ||:
Zfish   601 RNTEQPVKPKLHEQVVQ-------SRPRSSSF-----------PSTVTRVMSGPASKQQRTPQPV 647

  Fly  1363 KRTTSQVELKTTA-----EKPTKVTIENQAHHRFELALQESKVDAVNCVVCEKAVVAGSPFWKCK 1422
            .|:.|.|..||:.     ..|...:.|:.:....|...:|...|..:..:.:|.|:..|...|.:
Zfish   648 PRSRSNVPHKTSTPLQHRRTPPFSSDEDSSEEEEEEEEEEESSDEESPQMQKKTVLVNSSTAKAQ 712

  Fly  1423 ECKDVTHRKCRSNVQSHCGSTKPTAPSADDLSSIQSVSSLTLDSVDVAGGTTSGGEYIGSLVYSS 1487
            .         .:..||...|.:|    |..|:|.:..:..||...|                 .|
Zfish   713 N---------TAKTQSTAQSVRP----AVALTSAEPTNVTTLSDSD-----------------WS 747

  Fly  1488 DGAE------DQARKEIEVNCAFE-VAEQQILLL------------------GCNTGL------- 1520
            ||:|      .|..|..:.|...: |....:..|                  |.||.|
Zfish   748 DGSEMEEINLSQLHKHTDQNGNLKNVTHSNVKALGKSLEKQLAARGPKKPAGGVNTFLEKPTEVR 812

  Fly  1521 -----------YAYHLDSQRLVHISGLESVSCMSICKRLAKAIMVGTVGEKLYQCDY---RQLES 1571
                       |:...|......||.||.|..::                |..||..   :.|:.
Zfish   813 NTRQNAKKELKYSDDDDDDDDWDISSLEDVPAVA----------------KPTQCPVPVRKSLDK 861

  Fly  1572 RCQSSSSC--------HKPVLETSAIELPFANRTPSEKWKLVLISD 1609
            ...:|:|.        |||.|..       |....:.|..||.:||
Zfish   862 SQDTSTSVWGSSTGKGHKPGLTD-------AGTASTLKSSLVTVSD 900

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sti	NP_001261768.1	PKc_like	111..452	CDD:304357
		S_TKc	113..383	CDD:214567
		Smc	487..1222	CDD:224117	116/558 (21%)
		CNH	1503..1774	CDD:279162	29/155 (19%)
dzip1	XP_005165761.1	Dzip-like_N	65..185	CDD:290529	28/156 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000